The results of therapeutic pneumoperitoneum which was induced in 60 patients can be summarized as follows:
1) The cavity closure was observed in 100 per cent in lower, 27 per cent in middle, 8 per cent in upper lung field. It seems that the lower the position of tuberculous cavity in lung, the better the influences of therapeutic pneumoperitoneum.
2) The longer the duration of therapeutic pneumoperitoneum, the better is the sputum conversion.
3) Approximately half of the patients had decreased both in cough and sputum volume, and 37 per cent had improvement in the erythrocyte sedimentation rates. But decrease in weight was observed in larger number of patients.
4) No fatality resulted from complications. But in 18 per cent of the present cases the therapeutic pneumoperitoneum had to be discontinued because of complications.
5) In 5 cases both sides of the diaphragm were elevated, especially on the right. Ele-ctrical position of the heart became more horizontal and the transition zone was shifted to the right following treatment. In 1 case both sides of the diaphragm were elevated, especi-ally on the left. Electrical position of the heart became more vertical and transition zone was shifted to the left following treatment.
6) Bronchoscopic examination showed the mechanical stenosis of lower main bronchus and each of the visible bronchial orifices.
7) Bronchographic findings as follows: the cephaladly directed bronchi inclined to move upwards, and the lower ones horizontal. The shift of the latter showed much more than that of the former.

抄録全体を表示

I have studied on the routine blood culture method. For this purposes, three strains of Strept. viridans and one strain of Strept. anaerobicus, isolated from endocarditis lenta, and as control Strept. hemolyticus (Cook), and Staphyl. aureus (Terashima), were used. The conclusion gained was as follows.
1) As anticoagulant, one fifth or one tenth volume of 5-10% Na. citrate solution should be added to blood.
2) As enriching media, bouillon, 1% glucose-bouillon, 10% peptone-bouillon and 10% peptone bouillon with vitamine Bl (5 mg) are excellent. When simultaneously two or more media are employed, a better result is obtained than by a single medium. Para-aminoben-zoic acid, thioglycollate natrium and saponin showed no remarkable results.
3) As the media for pour plate cultivation, 1% glucose-agar or normal agar should be used.
4) The blood culture method should be repeated by the direct pour plate cultivation and should use various methods conjointly.

抄録全体を表示

The bacteriostatic effect of a chemotherapeutics depends more or less upon the kinds of culture medium to be employed. The following results were obtained in the experiments on the bacteriostatic effect of INAH, DSM, PAS, TB1, Cepharanthin, Vitamin K, Z-Furan, Monafuracin, Guanofuracin, Protozol, Protomin, Diazone, and Neo-Minophagen A. T upon tubercle bacilli (H37RV), using Proskauer and Beck, Kirchner and Oka-Katakura media.
1) INAH seems to be more powerful than any other compounds in Proskauer and Beck medium, Kirchner's medium and Oka-Katakura medium.
2) Bacteriostatic effect of DSM and PAS rank next to INAH in three, media employed.
3) Cepharanthin and Vitamin K significantly decrease their power in Oka-Katakura medium.
4) TB1 shows nearly identical power in each of the three media. Similarly Z-Furan, Monafuracin and G uanofuracin.
5) Protozol, Protomin and Diazone show a marked decrease of their power in Kirchner's medium.
6) Neo-Minophagen A. T does not show its power at all in the three media employed.
7) In general, the bacteriostatic effect of antituberculous drugs is most powerful in Pr-oskauer and B eck medium, and it has a tendency of less effectiveness in Kirchner's medium and in Oka-Katakura medium

抄録全体を表示

There are two methods for the investigation of the galvanic skin reflex: potential-method (Tarchanoff) and the resistance one (Veraguth). As to the characteristics of these methods, the former has methodological difficuties, and the latter has difficulties in its qua-ntitative measurement, in spite of its practical convenience.
In order to resolve some of these difficulties, studies on the influences of electric current upon the galvanic skin reflex were executed on 30 cats,
As a rule, two reflex curves were recorded simultaneously from the both fore paws by means of vibrator-F (5×10^-7A, 35 c/s, 60Ωof the electromagnetic oscillograph. For this purpose, a pair of so called simple circuit were used for the studies which consists of battery, vibrator-F, microammeter and two Zn-ZnSO₄ kaolin elctrodes in series.
Faradic stimulation was delivered in hypothalamus near tuber cinereum by coaxial needle electrode which inserted into the ether-narcotized cat's brain.
Followings were the results of the studies:
1) The galvanic skin reflex could be recognized in four paws of cats by hipothalamic stimulation. At room temperature of 22-30°C and 200-300μA of the circuit-current, the latent time of the reflex curves was 0.8-1.3 second (average 1.1 second) and the reaction time (the time from the rise to the top of the curve) was 1.2-4.0 second (average 1.9 second).
2) In the constant current of the circuit, as the stimulation became stronger by shorten-ing the coil distans, so the amplitude of the reflex curves became higher. This may be diff-erent result from that of the potential method reported by Richter and patton.
As the interval of the single shock of the stimulation became shorter, so the reflex cu-rves superposed themselves and at last formed a very high summation-curve. This may be also different result from that of the potential method.
3) If the strength of the circuit-current was increased from 50μA, step by step, to 300μA so the amplitude measured by “change in current” increased gradually, and when it was measured by “change in resistance”, so it showed the tendency to decrease. For the control the value of the electric current of another side was kept constant during this experiment.
In addition to this, as the strength of the electric current increased, so the reaction time of the reflex curves showed recognizable elongation in comparison with that of the control seide.

抄録全体を表示

We have studied on the made of dissemination of BCG in the animal body, and tubercul-in reaction with guinea pigs.
The results obtained are as follows:
1) BCG inoculated subcutaneously or intracutaneously, does not remain in the local glands, but disseminate into the various organs (liver, kidney, lung, spleen, etc). The amount of BCG decreases in three weeks or so after injection, and it could not be found at five weeks in the organs.
2) The skin into which BCG was injected was removed at various intervals and the tu-berculin reaction was tested. The reaction was found positive in the guinea pig from which skin was removed locally at the area of BCG tested one week after the injection. The local skin plays no significant role in changing the tuberculin reaction into positive.
3) In gaining immunity or tuberculin allergy not only the injected local skin but all the visceral organs are considered involved.

抄録全体を表示

The screening tests with mice were attempted for the following chemotherapeutic agents in a manner identical with the one described in the first report.
1) The administration of 40 mg of isoniazid daily per kg was more markedly effective than that of 200 mg of streptomycin per kg per day.
2) Combined daily isoniazid (40 mg per kg) and streptomycin (200 mg per kg) was more effective than each drug alone;a combination of even half dose of both drugs was almost equally effective.
3) Neo-minophagen A. T. alone had little effectiveness, but a combination of it and strept-omycin was found to be more effective than streptomycin alone.
4) Isoniazid in comparison with streptomycin more favorably effected experimental tuber-culosis in mice infected with human type tubercle bacilli resistant to more than 1, 000 γof streptomycin per ml. of egg-yolk medium.
5) Streptomycin-resistant tubercle bacilli (1001) were isolated from one of the streptomy-cin-treated mice, but isoniazid-resistant ones did not appear in our experiment.
6) The treatment with streptomycin in infections caused by streptomycin-resistant tubercle bacilli did not enhance the drug-resistance, and isoniazid did not alter the streptomycin-resistance.

抄録全体を表示

In the previous paper, local effects of various kind of drugs on skin were reported. In the present report urticaria was studied as a part of the central system with following tech-nique. After various kinds of drugs were injected subcutaneously in the arm of a patient, who was subject to artificial urticaria, a pressure was applied to the forearm. There was noted great differences in sensibilities among the patients. In an insensitive patient in whom the symptom appeared when 800g of impacting power was applied showed various titers ranging 703g to 900g according to the day of experiment. Most of drugs showed its highest effects 40-60 minutes after injection and in 2 hours activities have disappeared, In a sensitive pa-tient who developed oedem by application of 180g of impaction showed a fixed titer in each experiment, but no effective changes were observed after injection of drugs. The titer on the average is 250g in the former, while that of latter is .70g. This is well in accordance with the formula of Weber-Frechner modified by Tamiya.
E=susception
E=alnI+C I=stimulation
C=constant

抄録全体を表示