Following examination was undertaken to investigate the postoperative amount of urobilinogen (UR) and Millon's reaction (M), their daily variations, relation to the location and duration of operation, and to the method of anesthesia. Moreover the effects of two kinds of therapeutic agents i. e. the preparation of methyl-androstendiol and glucuronic acid, on the amount of UR and M were studied simultaneously. These effects and relations were compared every time between groups of the approximately same average duration of operation.
The subjects consist of 40 inpatients, and 9 healthy control cases. The former was itemized 24 gastrointestinal, 7 uterine, and 9 extraperitoneal cases. According to the methods of anesthesia; 26 general, 8 lumbal and 6 local cases.
The first urines were collected every morning from the 2nd preoperative to the sixth postoperative day, and the amount of UR and M were determined by the method of Watspn and Imanaga respectively. To check changes due to daily variations of urine volume, creatinine ratios were calculated.
Results were summarized as follows:
(1) UR and M increase generally after surgical operation, culminate on the 4-5th postoperative day, and there are significant correlation between two values. (correlation coefficient=0.80)
(2) There are significant correlation between the duration of operation and total UR or M, which are excreted during six days after operation. The correlation coefficients are 0.62 and 0.67 respectively.
(3) The total postoperative UR excretion is:
1) Less in lumbar anesthetized uterine than general anesthetized gastrointestinal operations.
2) Less in extraperitoneal than intraperitoneal operations.
(4) So far as examined, there are no influences of methyl-androstendiol and glucuronic acid on the total postoperative UR or M excretion.
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