A daily subcutaneous injection of 10mg of vitamin B₁ was given to 23 tuberculous patients and 9 normal persons as control Prior to and after administration of vitamin, serum iodate level and plasma tryptophane level were quantatively determind and blood sedimentation rate was checked.
The results are as follows:
1) Compared with normal persons, tuberculous patients showed an increase in all of the serum iodate level, plasma tryptophane level and the blood sedimentation rate. The rate of the increase paralleled the severity of the disease process although there was no remarkable difference between the serum iodate level in far advanced cases as compared with moderaterly advanced. Almost parallel transition was observed between plasma tryptophane level and serum iodate level on one hand and blood sedimentation rate and tryptophane level on the other.
2) The administration of vitamin B₁ resulted in a remarkable decrease of serum iodate level and a slight decrease in plamma tryptophane level. In normal persons only a slight decrease was noted.
3) Following administration of vitamin B₁ the blood sedimentation rate showed a slight improvement in moderately to far advanced cases.
From this experiment it may be stated that a massive administration of vitamin B₁ gives a favorable influence upon intermediary protein metabolism in pulmonary tuberculosis.

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After applying four ring-shaped mechanical stimuli over the area to which intradermal injection of various drugs had been given in the forearm of allergic patients, the contour of the ring and the time of its disappearance were measrured.
The result showed that antihistaminic drugs did not cause a rapid disappearance of the ring shaped edema. Rather the drugs which act upon autonomous nervous system were found to expedite the disappearance of the local edema.

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A study on the galvanic skin reflex was made in ten adult females at three seasons, namely spring, summer and winter. Reflex curves were recorded simultaneously from the thenar and hypothenar regions by attaching two apparatuses of so called simple circuits and vibrator-F (5×10^-7 A, 35c/s, 60Ω) of electromagnetic oscillograph using Faradic stimulation. The study was based mainly on latent and reaction times of the reflex curves. The skin temperature was measured by thermojunction at each examination.
The results are as follows:
1) The latent and reaction times were markedly prolonged in winter as compared with those in spring and in summer. In winter the mean latent and reaction times were 2, 75″ and 4, 51″ respectively as against 1, 72″ and 2, 15″ in spring and 1, 79″ and 1, 78″ in summer. 2) Findings of simultaneous recording when both index fingertips were being attached to the electrode:
Within five minutes after immersion of the right index finger into the warm water a reduction of the latent and reaction times were noted. When placed in cold water a prolongation of the latent and reaction time was observed, and in icewater no reflex was elicited although a definite reflex curve was shown in the control.
3) When stimuli were applied to the lumbar sympathetic ganglion, a similar reduction of the latent and reaction time was observed in three cats which were being warmed with electric heater.
From these findings it is considered that the seasonal difference of the galvanic skin reflex of the thenar chiefly depends on the skin temperature which is lowest in winter and highest in summer. However, the factor of seasonal adaptation of sweat gland cannot be disregarded in the causation of this difference of reflex.
4) Of ten persons in whom the examination was caned out the reflex curve of the hypothenar region was elicited in six in summer, three in spring, and none in winter.
When a limited area (about 1cm square) of the hypothenar region where electrode was attached, was heated for 30 minutes, reflex was observed in two of six tested in warm spring days, while none responded in cold winter days.
On the basis of above experiment, it may be stated that reflex of the thenar and hypothenar regions differ according to season as well as when heat is locally applied.

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6 of 13 cases were completely cured and 4 remarkably improved with the intermittent injections of Streptomycin (SM) directly into the cold abscesses after aspiration of the pus, consisting of 0.1-0.5g, administered once to three times a week. On some cases of intramuscular injection, SM cannot be found or in very low concentration in the pus.
This is a reason why the local application is more effective than the intramuscular injection. The cases which had the large retention rate of the injected phosphorus isotope (P³²), are remarkably improved by the local Streptomycin therapy. The pus became thinner and bloody at the end of this treatment and the protein of the pus decreased but PH did not show no change, keeping about 6.4-7.2. The blood sedimentation rate had increased temporarily but decreased with the improvement of the symptom. The pathological study revealed the demarcation, new-building of capillaries and fibrosis with the examination of experimental animals (rabbits).
The abscesses which are smaller than eggsize and easy to puncture of the pus, showing distinct fluctuation, are expected good results.
If there are no improvement after over 15 times of injection, it is better to be operated.
The mechanisms of this therapy are follows: interuption of the growth of tubercle bacilli in the abscess; removement of caesous mass and pus; new building of good granulation accompanied by new capillaries; production of fiber and so on.

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Some of the SM- or Pc-resistant variants which are different from the parent strains in the biological characteristics were used in this study.
Immune serums against the parent strains, SM- or Pc-resistant variants and reverse mutants were made, and the searches of serological characteristics of them were performed. It was known that antigenically the Pc-resistant variants and parent strains were not alike in the case of Saigon strain. But it was not concluded that this fact was due to the penicillin only, for if all the Shigella dysenteriae were cultured in the aerobic condition, they often became antigenically different from the parent strains.
In the case of Shiga strain the SM-resistant variant was antigenically no different from the parent strain.

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Using survivor curve computed from his materials and age-distribution of time from onset of tuberculosis, the author calculated theoretically the age-distribution and death on tuberculous patient and compared those theoretical distributions with statistical distributions. He also calculated expectant life span for tuberculous patients from his materials and obtained 2.69 years for male, 2.16 years for female. Multiplying those numbers into the number of death from tuberculosis he estimated number of patients as approximately 500, 000 in Japan.

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In his former publications the author expressed a view that streptomycin intramuscularly administered is excreted in feces chiefly through the exposed blood vessels of the tuberculous intestinal ulcer.
The author carried out a further study on sensitivity and resistance of e. coli to streptomycin in the intestinal tuberculosis and has come to following conclusions.
1) when streptomycin was given intramuscularly to tuberculous patient the resistance of e. coli to streptomycin occurred almost immediately and it was retained in longer duration and in higher concentration than was found in healthy control group.
2) The Asaba's test gave a positive reaction to the intestinal tuberculosis group and negative to the control group. It also had a tendency to show negative reaction as improvement of clinical findings were noted by the strepomycin therapy.
3) The streptomycin excretion in feces was observed in 14/16 cases of the intestinal tuberculosis group. It showed a decrease or complete disappearance in proportion to improvement of clinical findings. There was no excretion of streptomycin in feces in the healthy control group. Thus it is considered that streptomycin is excreted chiefly through exposed blood vessels of the intestinal ulcer.
4) The searth for any influence of the intramuscular administration of streptomycin upon the growth of e. coli group revealed very little. Whereas a definite deminution of the number of colonies was noted within a few days after the beginning of streptomycin administration, it soon recovered its normal rate of growth. As to the correlation between bacterial types of the coli group and the nature and consistency of the feces, there was no remarkable findings.
5) It is considered following three tests are of important value in the diagnosis of the intestinal tuberculosis:
the Asaba's reaction, test for streptomycin excretion in feces and streptomycin resistance test for e. coli in feces.

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