A baby girl, at the age of 5 days, has had a widespread bullous eruption and defect of epithelium involving the mouth, elbows, feet, knees, and ankles, since her birth. The nails were thickened and clawlike. There is no family history of this condition. The baby was quite well nourished, and at first, three was some improvement, but fresh bullae continued to appear. She stopped eating and lost weight, and died at the age of 82 days, autopsy was performed. Autopsy findings: The death of the patient was due to bronchopneumonia directly. The significant microscopic changes were hypoplasia of the thymus, lymphfollicls of the spleen and other lymp happaratus. Histopathologic specimen of the skin showed that the bullae were formed between the epidermis and the corium. PAS-positive basement membrane was located on the side of the epidermis, not corium. We think that epidermolysis bullosa hereditaria dystrophica et polysplastica in the newborn have to be differentiated from epidermolysis bullosa letalis clinically or histologically.
In order to investigate the relation between the suffering from Tinea pedis and local factors of foot of the host, fifty three students, aged 19-21, of a nurse school were examined. A comparison was made between healthy feet and those affected with Tinea pedis in relation to the selected eleven anatomical, physiological and biochemical local factors. A significant difference was noted in the big toe angle, the little toe angle, the crossing toe angle and interdigital distance. The big toe angle and the crossing toe angle were significantly larger among the feet with interdigital lesions. Interdigital distance of feet was significantly shorter among the infected. The little toe angle was significantly larger among the feet with the fourth interdigital lesion. All of the stated factors indicated the closing tendency of the toe constructure, which may well be related to the infection of Trichophyton, because interdigital space of this type of foot tends to be more irritated, to have high alkalinity of the skin and the humidity. These closing tendency of the interdigital spaces might be due to the wearing of occlusive foot-gears. Hyperhidrosis was also significantly related to the affection of Tinea pedis.
A clinical trial of the long acting antihistamic agent “Chlorpheniramine Nyscaps” was estimated on 37 cases of pruritic skin diseases, consisting of 10 cases of urticaria chronica, 2 of urticaria acuta, 3 of pruritus cutaneus universalis, 1 of erythema annulare centrifugum, 1 of erythrodermia, and 19 of eczema and/or dermatitis. 1. The daily dosage was 8∼16 mg, administrated orally once a day. 2. The duration of therapy was from 3 days to 7 days. 3. The result of clinical effect was evaluated as follows: it was markedly effective in 11 cases, and moderately in 17 cases, (consisting of 7 cases of urticaria chronica, 2 of urticaria acuta, 2 of pruritus cutaneus universalis, 1 of erythema annulare centribugum, 1 of erythrodermia and 14 of eczema and dermatitis). 4. The urinary and liver function tests were carried out in 7 cases given 16 mg of Chlorpheniramine Nyscaps daily for 14 days and no abnormal sign was observed. 5. Side effect was observed only in 2 cases. It was drowsiness in both cases. We believe clinical administration of this drug will be favorably beneficial to treatment of pruritic skin diseases.
Drenison Tape, an adhesive tape which contains 4 mcg of flurandrenolone per square cm, was used in 39 patients with various dermatoses. 3 cases were classified as markedly effective, 5 fair, 8 unchanged and 8 worsened. This was because Drenison Tape was used in a variety of lesions in order to find indications. Responsive dermatoses include various types of chronic eczema, keratodermia tylodes palmaris progressiva, psoriasis vulgaris, neurodertnatitis and pustulosis palmoplantaris. On the contrary, acute dermatitis and skin dermatoses where sweating is considerable do not appear indicated. The relationships among the occlusive dressing technique, double layer method and Drenison Tape treatment were discussed.