The author has traced his own researches during the past thirty years and explained the outline taking up the results of several principal ones. Furthermore, the author gave a full detail of the results of his own researches in recent four years since he worked at Kawasaki Medical School, and also referred to visions of the future.
Systemic corticosteroid therapy was re-evaluated. Short-acting steroids, such as prednisolone, are preferred to long-acting steroid in prolonged steroid therapy. Steroids are indicated primarily in self-limited diseases, not responsive to other therapies. On the other occasions, it is advisable to withdraw from steroid therapy at least within one month. On the methods of administration, much thought should be given to the initial dose, methods of reduction, withdrawal and time of administration. Severe and interesting side effects of steroid therapy were mentioned.
Eighteen patients with chromomycosis in Japan were treated with 5-fluorocytosine (5-FC). They received orally 5-FC in a dose of 4 to 10g daily for 1.5 to 18 months. Eight patients were cured or almost cured. Nine patients were improved, but four of them were relapsed. No response to treatment was observed in one patient. No side or toxic effects were encountered. A 47-years-old male with chromomycosis due to Fonsecaea pedrosoi was reported. He was treated with 5-FC in a dose of 8g daily and improved.