An electron microscopic study on the skins of human fetuses of 21 weeks of menstrual age revealed the following structures in some undifferentiated-type cells: (1) a certain foamy structure contained within a glycogen area consisting of clustered vesicles (Fig. 3, F). Each of these vesicles showed the profile limited not by a unit membrane, but by a less electron dense thin layer of circular form; (2) an empty structure contained within a glycogen area (Fig. 4, E); (3) a myelin figure enclosing various amounts of glycogen area (Fig. 5, My
1, My
2); and (4) a single membrane-limited dense body containing electron dense matrix (Fig. 4, D). These structures seemed to suspect that every one of them may represent one aspect of precursor stage of the lipid formation occuring in the undifferentiated-type cell and being closely associated with the glycogen metabolism.
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