The utilities and the problems of corticoids are already well known. However, it is difficult to grasp the character of each corticoid since there are various kinds of corticoids with different chemical structures and moreover their physiological and pharmacological effects are complicated. This paper is especially intended to classify each topical corticoid in the aspects of chemical structure and biological activities for the convenience for the people concerned in the medical field.
Since the cleavage products of C4 are guides to classical pathway activation, we have extended our previous studies in order to characterize the mobility on immunoelectrophoresis, chain structure and amino termini of the products produced by Cls and the further degradation by the C3b-C4b inactivator combined with a high molecular weight (10S) heat and DFP resistant factor. C4 has three chain structure and the NH2-terminus of the α and γ chains was Glx, while that of the β chain was not detected. On addition of purified Cls, the NH2-terminal portion of the α chain of C4 was released and C4a and C4b could be identified. Ala was the newly liberated NH2-terminus of C4b. Highly purified C4b was then reacted both sequentially or collectively with the C4b INA and the additional 10S cofactor. Alteration of the structure of C4b was detectable only if the purified proteins were present simultaneously. Cleavage into two components, C4c with a molecular weight of 14×104 and C4b, the α mobility fragment (molecular weight 5.8×104) was found.
A Statistical survey of viral disease in Department of Dermatology, Tokushima University, for the last 14 years from 1964 to 1977 was reported. The proportion of viral disease to the outpatients was 4.40% and the ratio between male and female was 1 to 1.45. Viral disease were classified to herpes zoster (25.98%), verruca vulgaris (25.74%), verruca plana juvenilis (17.21%), herpes simplex (11.71%), molluscum contagiosum (9.59%), varicella (3.56%), condyloma accuminatum (1.78%), rubeolla (1.54%) and others (2.84%).