115 cases of lichen amyloidosus were found in a skin clinic in Taiwan during a pariod of 4 years. Lichen type occurred in 78 cases and 10 cases of macular type and 27 cases of biphasic type were seen. The great majority of the patients were middle-age males with a long duration of the disease over than 5 years. The extensive surfaces of the limbs were most commonly involved. Crystal violet staining is the most simple and reliable histochemical method to make a firm diagnosis. If the equipment available, fluorescent microscopic studies of thioflavin-T or Phorwhite BBU are useful for diagnosis. Immunoglobulin assay showed within normal limits in 12 cases of lichen amyloidosus. T and B cell ratio was normal in 8 cases but 15 out of 16 cases revealed positive immunofluorescence in either IgG, IgA, IgM or C3. Selectively, skin abrasion was carried out in 25 cases ; 6 cases had no reccurance after a three-year follow-up. Positive amyloid deposits were seen in the clinically normal looking skin about 10 cm from the lesion in 6 out of 12 cases with lichen amyloidosus. In secondary cutaneous amyloidoses, amyloid deposits could be seen in basal cell epithelioma, seborrheic keratosis, porokeratosis and Bowen's disease but in 20 leprosy patients, no amyloid was found in the skin biopsy materials.
1. Multicentric clinical trials on triamcinolone acetonide cream with new formulation were conducted at eleven medical institutions to assess its clinical efficacy in comparison to the old cream. The new cream formulation has several distinct features, e.g., (a) benzyl alcohol as a preservative instead of parabens, (b) increased water content, (c) new type emulsifier. In order to asertain the clinical efficacy of the new cream formulation the limited double-blind method was adopted. 2. In these clinical trials, a total of 129 patients were tested and analyzed ; 43 patients with the exudative type of eczematous dermatitis, 42 patients with the lichenified type of ec-zematous dermatitis and 44 patients with psoriasis vulgaris. 3. Analyses in the 95% significance level (p≤0.05) indicated no significant difference between the new and the old cream formulations in all types of dermatitis involved. However, it was suggested that the new cream formulation was clinically more effective than the old cream formulation particulary in psoriasis vulgaris and the exudative type of eczematous dermatitis from the results of drug preference. 4. The questionaire conducted with regard to the property of the new cream formulation in clinical use indicated that the new cream formulation was superior to the old cream in its' extension, refreshing feeling and vanishing on the lesion. 5. The study showed that triamcinolone acetonide new cream formulation is more useful than the old one.