The literature on dermatophytosis and its causative fungi in Kyushu district during a 45-year period (1924∼1968) has been reviewed. In tinea capitis, Trichophyton ferrugineum was the most common species isolating in 67% of cases; followed by T. glabrum, 24%; T. violaceum, 5.1%: T. gypseum (asteroides), 1.3%; T. rubrum, 0.3%; Microsporum gypseum, 0.2%, and T. coccineum, 0.7% respectively. However, not a single strain of T. coccineum has been isolated since 1950, and the incidence of T. ferrugineum in cases with tinea capitis has markedly decreased after the war. In southern part of Kyushu and Okinawa, T. glabrum and T. violaceum prevail over T. ferrugineum, showing geographical variation of the agents of tinea capitis. In tinea pedis, tinea unguium, tinea cruris, and tinea corporis, the most commonly isolated organism was T. rubrum, 71%; followed by T. interdigitale, 21%; T. gypseum (asteroides), 2.0%; Epidermophyton floccosum, 1.3%; T. ferrugineum, 1.2%; T. pedis, 0.8%; M. gypseum, 0.5%; T. glabrum, 0.2%; T. coccineum, 0.18%, and T. violaceum, 0.12%. The incidence of T. rubrum in cases with tinea pedis has been increasing.
1才2ヵ月の男子にみられたDysgammaglobulinemia type Iについて報告した。患者は生後間もなくより気管支炎や扁桃腺炎を繰り返し，また膿瘍を多発した。頸部，腋窩，鼠径部などのリンパ節の腫大がみられた。血清免疫グロブリンIgG 6mg/dl，IgA≒0，IgM 85mg/dlよりDysgammaglobulinemia type Iと診断した。その他プラスマ細胞が骨髄検査でもリンパ節の組織検査でもほとんどみることができなかつた。
215 nonsyphilitic sera and 105 syphilitic sera were examined by TPHA test (to use as antigen formalin treated tanned sheep red blood cells sensitized by T. P. Nichols strain and testing sera absorbed with T. P. Reiter strain and etc.,). Results: 1) On the nonsyphilitic sera 195 gave negative results to both of STS and TPHA, 6 gave positive results to TPHA and negative to STS, 14 gave negative results to TPHA and positive to STS. Then these were regarded as BFP, coinciding with results to FTA-200. 2) On the syphilitic sera 101 gave positive results to both of STS and TPHA. The reactivity to TPHA has been persistent after the antiluetic treatment. The sensitivity and spicificity of TPHA on syphilis might be satis-factory as that of FTA. Then the advantage of TPHA might be the stable graded agglutination figure on the hollow plastic plate for the test.
Thirty-nine patients with superficial dermatomycoses were treated with a new antifungal solution containing 3-(p-methylbenzylideneamino)-4-phenyl-thiazoline-2-thione and the excellent results were obtained. In cases with tinea cruris and tinea macrovesiculosa, the fungus disappeared from the lesion in two or three weeks after the initiation of the treatment. Side effects were minimum.
The therapeutic effect of antifungal agent, 3-(p-methylbenzylideneamino)-4-phenylthiazoline-2-thione referred as TBK hereafter, was clinically tested on some kinds of tinea. TBK preparations, in a form of carbowax ointment containing one (TBK I) or two (TBK II) percent, was applied. Of 30 subjects tested, there were 19 Tinea cruris, 10 T. interdigitalis and 14 T. pedis. TBK I was applied in 10 subjects and TBK II in 7. In the rest, both preparations were used—different lesions of same individual—for comparison of efficacy according to the concentrations. The therapeutic effects of TBK I and TBK II were 70% and 89% for T. cruris, 71% and 100% for T. interdigitalis, and 17% and 33% for T. pedis, respectively. As to side effects, contact dermatitis was observed only in a patient with T. cruris treated by TBK II.
The following results were obtained by our fundamental and clinical studies of a new antifungal agent, 3-(p-methylbenzylideneamino)-4-phenylthiazoline-2-thione (TBK). 1) The antifungal effect in vitro was found at the concentration of 3.12γ/cc against trichophyton mentagrophytes, 1.5γ/cc against trichophyton rubrum, and over 100γ/cc against candida albicans. 2) The healing rate of experimental trichophytia was 100 percent. 3) Clinically TBK-I solution (1%) and TBK-II solution (2%) were applied to 7 cases with tinea cruris and 17 cases with tinea pedis. TBK-I solution was very effective in 11 cases, effective in 7 cases, slightly effective in 2 cases, and ineffective in 4 cases. TBK-II solution was very effective in 12 cases, effective in 5 cases, slightly effective in 2 cases, and ineffective in 5 cases. 4) Side effects were observed in 2 cases.
Following results were obtained by our fundamental and clinical studies of Angimn. 1) Anginin was clinically applied to 52 cases of various skin diseases. Of these 52 cases, effective therapeutic results were obtained in 9 of 13 cases of urticaria, 6 of 10 chilblain cases, 2 of 4 cases of erythema exsudativum multiforme, 1 of 4 cases of erythema nodosum, 2 of 3 cases of chronic venous insufficiency and 4 of 17 cases of the other various skin diseases. 2) Though 8 cases of 52 complained the gastro-intestinal disturbances, other sevre side effect was not observed. 3) Urticaria, chilblain and a certain stage of chronic venous insufficiency were considered as to be the indication of Anginin therapy in dermatology. 4) The efficacy of Anginin for recover of skin temperatur from cold was examined. In healthy person this drug had no influence. In cases of urticaria and chilblain the effect was observed, while one cases of scleroderma diffusum showed the delayed recover of skin temperatur before and after therapy.