8 cases of sporotrichosis, which were examined in our clinic were reported. 4 cases of which were classified to cutaneous-lymphangitis type, and 4 cases solitary cutaneous type. 2 cases of which were infants and anothers were above 50 years old. Female were 7 cases and obvious trauma was observed 2 cases. Lesion of 5 cases was seen on upper extremity and 3 cases on face. Fungus culture was succeeded in 6 cases and spore type fungal element was demonstrated in 6 cases. Sporotrichin test showed the positive reaction in all cases. All of cases were treated with oral administration of potassium iodide. Side effect was recognized in 1 case, thereafter, it was treated with external application of iodide.
A case of partial albinism of a newborn, boy, was reported. The boy showed a white forelock and depigmented areas of extremities. The white forelock was present in his mother, maternal grandfather and mother’s brother through three generations of the family reported here.
Influences of climate on the occurrence of infectious skin diseases were investigated statistically by collecting the clinical records of two hospitals around Fukuoka district during 3 years. The results were them examined with the statistical methods (X2 test and Fisher’s exact probability test) and the following results were shown to be significant with a confidence limit of 95%. (1) Trichophytia pompholyciformis, Trichophytia eczematosa marginata, Pityriasis versicolor and Impetigo bullosa increased with high air temperature (above 16.2°C), high humidity (above 71.8%), long duration of sunshine (above 169.2h) and low atmospheric pressure (under 1014.6mb). (2) Multiple sweatgland abscesses of infants showed almost same tendency as (1) except that no correlation was observed with humidity. (3) Folliculitis increased with high temperature and long duration of sunshine. (4) Varicella increased with low temperature and short duration of sunshine. (5) Herpes zoster increased with much precipitation (volume of rain, above 116.1mm) and low atmospheric pressure. (Limits to judge each climatic factors “high” or “low” were their mean value; temperature 16.2°C, humidity 71.8%, duration of sunshine 169.2h, atmospheric pressure 1014.6mb, precipitation 116.1mm)
Griseofulvin could be assayed by gas chromatographic method. A Shimadzu GC-3AE instrument equipped with an electron-capture detector of pulse type and 2,000×4mm of glass column packed with 1.5% SE-30 on Chromosorb W (60-80 mesh) was employed. In the refining process of griseofulvin from extract, chromatography on 70×6mm Florisil colum was applied. Serum griseofulvin levels in 5 rabbits given simgle oral doses of 30mg/kg showed maximum concentration of 0.57∼1.50 μg/ml at 8 or 12 hours after administration, and decreased to 0.15∼0.30 μg/ml at 24 hours. Skin griseofulvin levels in the same rabbits showed maximum concentration at 4 hours in one case and at 8 or 12 hours in other cases, and it was 0.38∼0.83 μg/g. They decreased 0.07∼0.18 μg/g at 24 hours in all cases. In rabbits, skin griseofulvin levels paralleled serum griseofulvin levels and the former was lower than the later for the most part. Serum griseofulvin levels in 5 human subjects given single oral doses of 500mg showed maximum concentraton of 0.30∼2.30 μg/ml at 4 or 8 hours and decreased to 0.30∼1.04 μg/ml at 24 hours.
The following results were obtained by our clinical studies of a new antidermatophytic agent, “Polyodin” ointment and solution. Polyodin ointment and solution were applied to 52 cases with dermatophytosis. Polyodin ointment was very effective in 11 cases, effective in 14 cases, slightly effective in 1 case and ineffective in 1 case. Polyodin solution was very effective in 9 cases, effective in 6 cases, slightly effective in 5 cases and ineffective in 5 cases. In total, effectivity rate was 77 per cent (40/52). Side effects, such as skin irritation or dermatitis, were observed in 4 cases.