A statistical survey of dermatomycoses at Dermatological Clinic of Chiba University Hospital for the last ten years from 1965 to 1974 was reported. The proportion of dermatomycoses to the outpatients was 7.7% and has gradually increased since 1973. Dermatomycoses were classified to tinea (77.4%), candidiasis (12.9%), pityriasis versicolor (6.8%), sporotrichosis (1.8%) and others. The increase of candidiasis, especially intertrigo erosiva candidamycetica was remarkable. Sporotrichosis has increased recently. Causative organisms of the tinea were identified to Trichophyton rubrum (75.0%), T. mentagrophytes (19.0%), Epidermophyton floccosum (1.9%), Microsporum canis (0.9%) and M. gypseum (0.8%).
The intravenous doxycycline was administered in combination with oral placebo doxycycline capsule and the oral doxycycline was combined with the intravenous administration of placebo composed of FAD and intravenous doxycycline solvent. The administration was done once daily and the maximum duration of therapy was 7 days. The dosis of daily administration of doxycycline was 100mg. The efficacy of the two ways of administration of doxycycline against skin infections was compared and no statistically significant difference was found. The incidence of gastrointestinal side effects was significantly high in oral doxycycline group.