We report a rare case of nipple adenoma. A 38-year-old woman was examined for a small hard mass in the right mammary nipple. Cytological findings showed numerous duct epithelial cells with papillary clusters and a two-cell pattern mixed with myoepithelial cells. Apocrine metaplasia-like cells were observed, but with little atypia, yielding a definitive diagnosis of a benign tumor. This case demonstrates the importance of checking the appearance of atypia, cell cohesiveness, and two-cell pattern of duct epithelium to differentially diagnose cases such as this from Paget’s disease or invasive duct carcinoma.
A case of intravascular large B-cell lymphoma, a rare variant of malignant lymphoma, of the uterus is reported. A 70-year-old woman presenting with fever, edema of the lower legs and genital bleeding was found to have abnormal endometrial cytology, large atypical cells with coarse chromatin and conspicuous nucleoli were intermingled with endometrial epithelial cells. In the resected uterus, large atypical lymphocytes proliferating in small blood vessels of the uterine wall and a large endometrial polyp were noted. Immnohistochemical staining revealed that the atypical lymphocytes were positive for CD20. Careful cytological examination seemed to play an important role in the diagnosis and appropriate treatment of this case.