Wied stated in the Monograph “Cytopathology of The Uterine Cervix” Ed. Meisels and Morine, ASCP Press, that “Some tests are still going on, but they are essentially using the same old technology of the 1960 s and the 1970 s”. He evaluated the CYBEST, which we developed in 1972-1982 to be as the sublime system in the world up to the present time. The Neo Path engineering staff who developed Auto Pap, before accepted as the automated screeing system by FAD, officially offered at the meeting in Tokyo that know-how employed in CYBEST is employed in various stages of Auto Pap. This reflects Wied's description. The author presented technical know-how of the CYBEST including software program employing in CYBEST in this session. This must give significant and instructive informations for users of automation systems. Auto Map was developed in Auto Pap at our strong suggestion, following CYBEST 10 cell system. Thus, this may also give variable suggestions for the future improvement.
目的:コンピューター技術の急速な進歩に伴い画像解析技術が進み, 細胞診の自動スクリーニング装置が開発されてきている. 自動スクリーニング装置の導入目的として,「精度の向上」と「省力化」が求められる. わが国においては2000年に日本臨床細胞学会から陰性標本の10%以上のダブルチェックの必要性と署名の励行について見解が表明されたが, われわれの施設は1993年にCollege of American Pathologists (CAP) の認定を得たためCAPの精度管理基準に従っている. その精度管理基準により婦人科の陰性標本の10%以上を再検することが義務づけられている. そこでわれわれは, 1995年米国Food and Drug Administration (FDA) により認可された婦人科細胞診自動スクリーニング装置 (Auto Pap) を導入し1998年から精度管理を目的としたrescreening用としてroutineに使用し成果を上げている. さらに同装置は1998年に一次スクリーニング用として75%の再検必要率値の条件でFood and Drug Administration (FDA) に承認された. その一次スクリーニング用としての可能性も求め検討してきたので報告する.
A 71-year-old woman noticed a solid mass in her right breast and visited our hospital. The mass was diagnosed as apocrine carcinoma and tumor cells contained a large number of 3-37 km intracytoplasmic lumina (ICL) in the cytoplasm. Immunohistochemically, GCDFP-15, EMA, and keratin were positive in tumor cells, but CD 68 was negative.
We report a case of a 56 year-old woman with stromal sarcoma of the right breast. Macroscopically, the tumor occupied almost of the right breast with crater-like necrosis and hemorrhage. Histologically, spindle tumor cells were closely arranged in a herring-hone pattern. Immunohistochemically, tumor cells were stained with antivimentin. Cytologically, spindle tumor cells showing loosely arranged clusters. Tumor cells consisted of oval or spindle nuclei with a few mitotic figures. These tumor cells had no pleomorphic characteristics. The woman died of respiratory failure and had hypoglycemic attacks in the last few weeks of life.