The author studied the influence of swimming upon allergic rhinitis and IgE response with chlorine exposure in mice. The school children and children attending swimming clubs were examined to see the effect of swimming on allergic rhinitis, as swimming had appeared to have ill effect on rhinitis. The author noted that those who swim frequently tended to suffer from allergic rhinitis, and suspected that chlorine might havesome bearing. In order to see the effect of chlorine on IgE response, following experiment was carried out. Seven-week-old male BALB/c mice were exposed to 5ppm, 50ppm and 500ppm NaClO aerosol, and subsequently to 1% ovalbumin (OA) aerosol for 6 min. Seven days latter, these mice were injected with 10μg OA absorbed with 2mg aluminium hydroxide intraperitoneally to induce anti-OA IgE antibody. The mice were then bled every week after injection of the antigen. Titers of IgE antibody of pooled sera from each group were determined by passive cutaneous anaphylactic reactions. Results showed that the anti-OA IgE antibody production after intraperitoneal injection with OA was higher in the mice exposed to 50ppm NaClO aerosol than in the control mice non-exposed NaClO. There was no difference in IgE response between 5ppm and 500ppm NaClO exposed mice and control mice. To elucidate the mechanism of the effect of NaClO, the effect of NaClO aerosol on IgE primary response with intraperitoneal injection with OA and the influence of an intagastric administration with NaClO on IgE response were examined. No marked differences of IgE response were observed between the exposed and control group. These results suggest that an exposure to NaClO aerosol enhances an IgE antibody production, which can be attributed to the response by the respiratory tract and not by the digestive tract. As this report is concerned only with experimental study of IgE response with NaClO, further studies on the effect of swimming on allergic rhinitis would be necessary. The concentration of NaClO in the swimming pool should be monitored carefully because of probable ill effect of NaClO on the upper respiratory mucous membrane.
Immunohistochemical examination for cytokeratin was performed in the olfactory mucosa of guinea pigs. Marked cytokeratin immunoreactivity was found in the basal cells. Morphological examination with electronmicroscopy was performed at the same time. Abundant tonofilaments in which cytokeratin contained was found in cytoplasma and perikaryon of the basal cells. These findings suggest that the basal cells have the characteristics of epithelial compornent. So the theory that the basal cell differentiate to the olfactory receptor cell is unacceptable for us from this immunohistochemical and electronmicroscopic examination.
1. The changes in audiological finding after acoustic neuroma (AN) surgery and neurovascular decompression surgery were followed in patients who showed profound deafness postperatively. 2. Pure tone audiometric findings improved markedly within 1 month after surgery and continued to improve gradually thereafter. 3. Speech discrimination improved in parallel with the improvement in pure tone audiometric findings. 4. The stapedius reflex threshold became elevated or was absent after AN surgery but showed no abnormalities after Janetta surgery. 5. In ABR, the latency of wave V became prolonged postoperatively and only a slight improvement thereafter. 6. From these findings, we inferred that the postoperative disorders in pure tone hearing and speech discrimination were due to the disturbance of inner ear circulation caused by surgical manipulation. In addition, the gradual improvement in hearing after the first postoperative month was considered to be due to the improvement in the retrocochlear disorder.
A case of dysmorphobia that developed after submucous resection of the nasal septum is reported. The patient presumed that his dysphonia had developed due to a perforation of the nasal septum that developed after submucous resection 15 years ago. Rhinologic examination revealed pieces of chopsticks in the nasal cavity and also several perforations in the eardrum. The patient had been trying to close the septal perforation by inserting various materials into the nasal septum. The perforations of the eardrum had also been incurred by himself as he tried to relieve discomfort in the ear, that he believed also due to the perforated septum. Neurosis and personality disorder were suggested as diagnoses on psychiatric consultation. His complaints have been alleviated by cooperative treatments by rhinologists and psychiatrists.
The authors reviewed 190 cases of facial palsy who had been treated from 1975 to 1985 in the department of Otolaryngology of Jichi Medical School Hospital. (1) There were 91 cases of Bell's palsy, 39 cases of Hunt's syndrome, 18 cases of traumatic palsy, 13 cases of otologic palsy, 3 cases of oprative trauma, and 26 others. (2) In Bell's palsy, there were 36 cases of male and 55 cases of female and 53 cases on the right side, 36 cases on the left side and 2 cases on both sides. And 18 cases with Bell's palsy were between 0 to 9 years of age. There were no cases which showed a significant rise in antibody titers of Varicella zoster virus. (3) In Hunt's syndrome, there were 23 cases of male and 16 cases of female and 25 cases on the right side and 14 cases on the left side. (4) Eight cases with otologic palsy were between 0 to 9 years of age and all of them had an acute otitis media. (5) There was no case of operative trauma in the middle ear surgery in our department.
The authors report two cases of aspegillosis of the sphenoid sinus, whose diagnosis was facilitated by CT scan of the sinuses. A markedly deviated nasal septum in the two cases might have contributed to the development of the diease, The two cases were treated with endonasal ethmosphenoidectomy and antifungal agents with good results.
For the past seventeen years from 1968 to 1984, six hundred and sixty-one patients of recurrent laryngeal nerve (RLN) paralysis were found in our clinic. These patients were 359 males and 302 females from one-month to 94 years in age. In 591 cases, the vocal (cord) was affected unilaterally, 184 cases on the right side, 407 cases on the left side, and 70 cases bilaterally. These cases contain following disorders: 14 cases of central nerve disorder, 64 of cervical tumor, 124 of thyroid operation, 14 of other neck operations, 6 of neck trauma, 55 of tracheal intubation, 99 of chest disease, 41 of chest operation and 240 of idiopathic RLN paralysis. In the cases of tracheal intubation, chest disease and chest operation, the left vocal cord tended to be affected. But in the patients of esophageal carcinoma, the right vocal cord seemed to be more vulnerable. In the case of thyroid operation, RLN paralysis occurred in some cases on both sides and the thyroid operation is the main factor of bilateral RLN paralysis. In the case of idiopathic paralysis the relation between prevalence of influenza and the RLN paralysis was suspected.
The author devised a headlight using a fiber light source, combining advantages of both reflector and glass fiber light guide. The apparatus consists of three parts: a head band, a light guide cable and a reflector. The reflector, a plane mirror of 30×20mm receives the light axis through a light guide cable at an angle of approximately 45° and reflects the light foward. In the center of the mirror is provided a hole to fit a 10mm long cylinder of 5.2mm diameter through which visual examination is made. This device is used in a similar manner to conventional reflector or headlight by positioning the reflector in front of the left eye. The present fiber type reflector has a wide applicability in both outpatient clinic and operating room. The reflecting mirror measures 5.5cm2, and is far smaller than the conventional reflector of 50cm2. As a result, this device gives less obstruction to the peripheral visual field of a physician and allows writing or conversation with patients without changing the position of the reflector.