耳鼻咽喉科展望
Online ISSN : 1883-6429
Print ISSN : 0386-9687
ISSN-L : 0386-9687
17 巻 , 1 号
選択された号の論文の8件中1~8を表示しています
  • 鼻副鼻腔からみた前頭蓋底病態とその手術
    高橋 良
    1974 年 17 巻 1 号 p. 11-28
    発行日: 1974/02/15
    公開日: 2011/08/10
    ジャーナル フリー
  • 冨田 善治
    1974 年 17 巻 1 号 p. 31-54,2
    発行日: 1974/02/15
    公開日: 2011/08/10
    ジャーナル フリー
    I研究目的: 近年微生物学的に注目をあびているマイコプラズマは,(1) 家畜, 鳥類で, 慢性気道炎をしばしばおこすこと,(2) 感冒様症状をおこす多くの諸因子の中の1っであり, 慢性気道炎の増悪をきたすこと,(3) 気道粘膜より比較的長期にわたり排菌され, 炎症を遷延せしめるのではないかと考えられていることなどより, 著者はマイコプラズマの慢性鼻副鼻腔炎の病態におよぼす役割について検索した。
    II研究方法:(1) 鼻副鼻腔よりのマイコプラズマの分離。正常人, 慢性副鼻腔炎手術患者および慢性副鼻腔炎急性増悪症患者の上顎洞ならびに中鼻道よりマイコプラズマの分離をこころみ, 分離株は標準家兎血清で同定した。(2) 血清疫学的研究。慢性副鼻腔炎急性増悪症患者および対照正常人血清にっいて, 補体結合反応 (C.F.), 間接赤血球凝集反応 (1.H.A.) を用いM.pneurnoniaeの抗体価を測定した。
    III研究結果および結論:
    (1) 副鼻腔炎手術患者98例の中鼻道より4例4.1%に, 上顎洞粘膜48例中1例2.1%にマイコプラズマを分離しえた。但しいずれも寄生性非病原性とされているM.salivarium, M.orale typeIであつた。
    (2) 慢性鼻副鼻腔炎急性増悪症患者108例の中鼻道より7例6.5%にマイコプラズマを分離した。但し病原性のあるM.pneumoniaeは分離されずM.salivarium, M.oraletypelであり, 分離された症例はいずれも口腔咽頭よりも同じ種のマイコプラズマを分離した。慢性炎を有する鼻副鼻腔の粘膜にマイコプラズマは定着しやすく, おそらく口腔咽頭よりのContaminationと考えられた。
    (3) 気道疾患のみられない正常人168例の中鼻道よりの検索では全くマイコプラズマは分離されず, 正常な鼻腔の細菌叢としてはマイコプラズマはみとめられないと思われた。
    (4) 非病原性とされるM.salivariurn, M.orale typeIにもLow virulenceを暗示する種々の毒性表現が知られており宿主の局所の感染防禦機構の減弱や抗生剤の使用により, Opportunistic mycoplasmal infectionの可能性も考えられた。
    (5) 昭和44年度に測定した慢性副鼻腔炎急性増悪症患者血清のC.F.抗体では同時期の対照正常群血清に比して高レベル抗体保有率は高く統計学的に有意差がみとめられた (X2testp=0.05)。すなわち鼻副鼻腔炎群11.5%に対し対照群4.0%であつた。I.H.A.抗体保有率は高レベル抗体で正常群2.4%に対し患者群11.5%で統計学的に有意差がみとめられた (X2testp=-0.01)。
    (6) 対照正常群の年令別抗体分布では有意の差はみとめられなかつた。昭和44年度および昭和46年度の正常人の抗体価分布を対比すると高レベル抗体が46年度は成人に全くみられず, 44年度のみにみとめられ, 44年度の東京近郊でのM.pneumoniaeの局地的流行を推定せしめた。
    (7) 血清疫学的調査より, M.pneumoniaeは局地的流行がみられれば, 慢性鼻副鼻腔炎の急性増悪因子としてかなりの役割をしめるのでないかと推定された。
  • 前坂 明男, 米野 邦彦, 福田 学, 宮崎 為夫, 渡辺 幸夫, 室野 繁
    1974 年 17 巻 1 号 p. 59-65,3
    発行日: 1974/02/15
    公開日: 2011/08/10
    ジャーナル フリー
    A survey of patients with head and neck malignant tumors who visited our Otorhinolarygological Department at Kanazawa University Hospital during the period from 1963 to 1971 and did not return after the initial visit was conducted.
    The survey was in 3 parts, the first survey consisting of those who were seen in the period from 1963 to 1965, the second from 1966 to 1968 and the third 1969 to 1971.
    The patients with malignant tumors in each period were listed, and questionnaries were sent to them concerning the reason for their failure to return, the subsequent course of their disorder, profession, income, present address and so on.
    The answers were received from 76 among 146 patients. In analysing these answers, the following results were obtained:
    There were more patients with tumors in the digestive tract such as oral cavity, tongue, pharynx or esophagus, than those with tumors of the respiratory tract such as the nasal and paranasal cavities or the larynx.
    About forty per cent were being treated at other hospitals or clinics, while about sixty per cent died without effective treatments.
    As to the reasons of their failure to return, about sixty per cent preferred to being treated at other hospitals or clinics neaer to their houses.
    More than one half of the patients were living in rural or fishing districts.
    More than a half of the patients had expired.
  • 土田 武正, 上埜 光紀
    1974 年 17 巻 1 号 p. 67-71,4
    発行日: 1974/02/15
    公開日: 2011/08/10
    ジャーナル フリー
    Symphalangism is a rare malformation of the hands or feet and is characterized by the absence of the proximal interphalangeal joints of the finger and fusion of the talus and navicular bones of the foot.
    This condition is inherited as an autosomal dominant and is often associated with conductive deafness which is caused by the bony fusion of the stapes to the oval window.
    The Symphalangism associated with strabismus and impairment of hearing is also described but the simultaneous occurrence of these three anomalies is quite rare, and only two cases, of these malformations in a mother and her daughter, were reported by E.S. Vesell.
    The authors found three cases of symphalangism associated with strabismus and hearing loss in grandmother, father and son, and the possibility of a single gene producing the three malformations was discussed. The authors feel that it is difficult to conclude that the associated anomalies such as conductive deafness and strabismus are expressions of the symphalangism gene.
  • 飯沼 寿孝, 高橋 文夫, 江沢 暁彦
    1974 年 17 巻 1 号 p. 73-79,4
    発行日: 1974/02/15
    公開日: 2011/08/10
    ジャーナル フリー
    Five cases of rhinitis medicamentosa due to the excessive use of nose drops were reported together with the histopathological findings obtained from partially resected inferior nasal turbinates. These findings were similar to non-specific rhinitis. Degeneration of ciliated epithelium with squamous metaplasis, thickening of the basement membrane, small lymphocytic infiltration of slight to moderate degree in the tunica propria, fibrosis, and mild thickening of the larger blood vessels wall were noted. Eosinophilic infiltration was insignificant. It was suggested that the sustained and excessive use of the topical vasoconstrictors either caused stasis of the ciliary movement by altered viscosity of the mucous blancket or sustained stimuli to the alpha receptors in the nasal mucosa giving rise to ischemic edema of the tissue.
    The treatment consists in the correction of the lesions which initiated the excessive use of nose-drop and in the cessation of the use of the topical vasoconstrictors.
  • 谷 一郎
    1974 年 17 巻 1 号 p. 83-84,5
    発行日: 1974/02/15
    公開日: 2011/08/10
    ジャーナル フリー
    A case of lingual carcinoma occurred in a 81-year-old female who had frequent episode of stomatitis ophthosa is reported.
    Local findings, when referred initially to our clinic, were characterized by a leukoplakia on the left side of the tongue showing tumorous changes.
    Histopathological diagnosis of the lesion revealed acanthosis of the epithelium.
    Small round cell infiltration was seen without any specific changes.
    The patient was followed once or twice a month for 6 months, when she complained of local tenderness.
    The second biopsy showed carcinoma in situ. The treatment consisted in local radium irradiation and systemic administration of 5-FU, MMC, and endoxan, which showed a favorable effect on the course of the disease.
    The author suspected that the sustained local stimulation by a new artificial denture might have caused a chain of changes: leukoplakia acanthosis and carcinoma in situ.
  • 第74回日耳鼻総会の展示講演より
    樋崎 亨
    1974 年 17 巻 1 号 p. 89-91
    発行日: 1974/02/15
    公開日: 2011/08/10
    ジャーナル フリー
  • 長期追跡調査による薬効試験
    渡辺 動, 隈上 秀伯, 藤本 俊明, 川久保 淳, 小倉 脩二, 木村 繁, 古屋 正徳, 小林 康夫, 細川 彰, 益子 三郎, 佐藤 ...
    1974 年 17 巻 1 号 p. 93-101,5
    発行日: 1974/02/15
    公開日: 2011/08/10
    ジャーナル フリー
    The authors previously reported the clinical effect of MS-antigen in the treatment of nasal allergy as tested by a double blind test, where d-chlorpheniramine maleate was used as the placebo. The results were summarized that although no significant difference in the effectiveness was proved between the two groups immediately after the conclusion of the treatment, a significant difference was observed 4 weeks after the conclusion of treatment (P<0.05).
    The authors recently, 3-4 years after the previous test, conducted a follow-up study on the 71 cases which were judged effective in the previous test.
    Of the 71 cases, 43 cases (25 cases in MS-antigen group and 18 cases in placebo group) were located.
    The continuance of the effect after 3-4 years was confirmed in 44% or 11 cases out of 25, and 17% or 3 out of 18 in the placebo group, which was proved significant statistically (α=0.06).
    It was also revealed that relapse of the nasal symptoms in the MS-antigen treated group was seen within 20 months after the conclusion of the treatment and none relapsed after 21 months.
feedback
Top