A housewife, aged 27, visited ENT clinic of National Tochigi Hospital complaining of bilateral lagophthalmos. After spontaneous abortion she complained of difficulties with speech and swallowing manifested by hypernasal speech and nasal regurgitation. Muscle weakness increased characteristically as muscle activity continued: that is, there was easy fatigability. The symptoms tend to fluctuate from day to day. The diagnosis of myasthenia gravis was established by the injection of Tensilon and the results of EMG of masseteric and facial muscles. The x-ray exammination revealed thymic hyperplasia and paralysis of the soft palate. Treatments used were anticholinesterase drugs such as Vagostigmin, Ubretid, Mestinon, Myterase and ACTH. Tracheotomy and positive pressure ventilation were performed. Otolaryngologists should remember myasthenia gravis as one of the diseases with bilateral facial palsy.
The author observed some cases of rhinolaryngitis which appeared to have caused by air pollution. Considering that air pollution may cause a decrease in vital capacity, he used nebulization treatment of the disease obtainning favorable results.
A total of 30 patients, consisting of 15 adults and 15 infants with various otolaryngological infections were treated by Cepol dry syrup with good results. Sensitivity tests performed on the cultured organisms from the foci of infections showed a sensitivity rate of about 70% to Cepol. This drug was also found to be effective for some cases where AB-penicillin was not effective. One gram of Cepol dry syrup (Cephalexin or CEX) contains 100 milligrams of CEX. A high boold concentration of this drug after oral ingestion and rapid excretion in the urine have been confirmed in previous studies. In order to maintain the necessary blood concentration a dosage of 50mg/kg. body weight per day is adequate, in divided doses, 4 times before meals and sleep.