Although antihistaminics are usually effective to improve symptoms caused by allergic rhinitis, they have some drawbacks such as limited duration of the effect or causing drowsiness in some patients. A new antihistamine Y-5274 was tried in 100 cases of allergic and vasomotor rhinitis and its effect was studied by double blind method. The dose used was 6 tablets a day for adults and 3 tablets a day for children. In comparison to a placebo, the active drug showed significant effect for improvement of sneezing, nasal obstruction and nasal discharge.
Fracture of the frontal sinus associated with or without injury of the cranial vault often creates various later complications of the paranasal sinuses. One of the frequent complications is pyocele or mucocele of the frontal sinus. In order to prevent complications the authors used the positive approach of surgical intervention in five cases with fractured frontal sinus. Management of the fractured posterior table of the frontal sinus was often required during the surgical procedure. For management of the anterior table, special consideration was given for the postperative cosmetic effect. A close cooperation of s urgeon and otolaryngologist was emphasized for the treatment of such an injury.
Differential diagnosis of recurrent nerve paralysis is discussed, based on authors' experiences with different cases showing various causative factors. The authors stressed the importance of thorough examination of the intrathoracic organs and structures in order to reach the correct diagnosis. The authors emphasized the following essential examinations: 1. Chest X-rays 2. Physical examination and laboratory tests 3. Tomography of the intrathoracic organs 4. Contrast study and fluoroscopy of the esophagus 5. Bronchography and 6. Endoscopic examination.
Changes of the nasal and antral mucosae due to chronic sinusitis and allergic rhinitis have been studied by means of scanning electronmicroscopy. The findings were evaluated together with those obtained by contrast study of the antrum as well as by operations. The authors presented the followings as possible contributing factors for the creation of pathology in the paranasal sinus. 1. Decreased ciliary activity of the mucous membrane 2. Decreased capillary action of the natural ostium 3. Distorted nasal air flow. 4. Disturbed excretion of the antral contents 5. Disturbed gravitational flow of the contents 6. Disturbed excretion of the contents due to arterial pulsations 7. Destruction of the draining osseous ducts in the lateral nasal wall.