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[in Japanese]
Article type: Article
2005 Volume 79 Issue 1 Pages
1-2
Published: January 25, 2005
Released on J-STAGE: October 10, 2017
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Junji TERAO
Article type: Article
2005 Volume 79 Issue 1 Pages
3-11
Published: January 25, 2005
Released on J-STAGE: October 10, 2017
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Quercetin (3,3', 4', 5, 7-pentahydroxyflavone), a fiavonol-type fiavonoid present In vegetables, is of much interest as an anti-atherosclerotic food factor. Of all its biologlcal effects, the antioxidant activity seems to play a role in preventing atherosclerosis. However, bioavailability should be clarified to evaluate rightfully the biological effect of food factors. Quercetin frequently exists as its glycoside forms in plant foods. Glucoside-bound quercetin is mostly absorbed and hydrolyzed in small intestine through glucose-transport system or passive transport after lactase phlorizin hydrolase (LPH)-dependent deglucosidation. Quercetin glycosides other than glucoside forms are likely to be absorbed in large intestine after hydrolysis with enterobacteria. In both cases, resulting quercetin aglycone is converted to conjugated glucuronides and/or sulfates during the process of their absorption. Some metabolites circulating In the blood stream were found to act as free radical scavengers, as well as the inhibitors of lipoxygenase and xanthine oxidase. It Is unlikely that the conjugated metabolites invade into target cells directly because of their lower lipophilicity. However, quercetin aglycone may be again released and incorporated into the cells by the action of p-glucuronidase activity In the process of inflammation. Therefore, dietary quercetin can exert its various biological activities within the cells, as well as in the blood stream. In fact, we recently demonstrated in a rabbit study that dietary quercetin glycoside accumulates as its metabolites in the aorta, and attenuates lipid peroxidation occurring in this target site of anti-atherosclerosis.
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Sakayu SHIMIZU
Article type: Article
2005 Volume 79 Issue 1 Pages
13-21
Published: January 25, 2005
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he unique functions of sesamin, a lignan which is exclusively occurring in sesame seed (or sesame seed oil), are now waiting for a chance of "Open Sesame". Recent studies on sesamin clearly indicated its multiple biological functions. These include; (a) specific inhibition of Δ5 desaturase of polyunsaturated fatty acid biosynthesis In an arachidonic acidproducing fungus, Mortierella alpina, (b) interference with mammalian metabolism of linoleic acid, and hence, eicosanoid production, through an interference with Δ5 desaturase, (c) enhancement of the hepatic detoxication of chemicals and alcohol possibly through an Increased microsomal activity, (d) protective effect on chemically-induced mammary cancer, and (e) antioxidative potential in vivo. More preferable functions are expected to sesamin and the related lignans.
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[in Japanese]
Article type: Article
2005 Volume 79 Issue 1 Pages
23-26
Published: January 25, 2005
Released on J-STAGE: October 10, 2017
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[in Japanese]
Article type: Article
2005 Volume 79 Issue 1 Pages
27-29
Published: January 25, 2005
Released on J-STAGE: October 10, 2017
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[in Japanese]
Article type: Article
2005 Volume 79 Issue 1 Pages
30-32
Published: January 25, 2005
Released on J-STAGE: October 10, 2017
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[in Japanese], [in Japanese]
Article type: Article
2005 Volume 79 Issue 1 Pages
32-34
Published: January 25, 2005
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[in Japanese], [in Japanese]
Article type: Article
2005 Volume 79 Issue 1 Pages
35-
Published: January 25, 2005
Released on J-STAGE: October 10, 2017
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
2005 Volume 79 Issue 1 Pages
37-
Published: January 25, 2005
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[in Japanese]
Article type: Article
2005 Volume 79 Issue 1 Pages
38-
Published: January 25, 2005
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[in Japanese]
Article type: Article
2005 Volume 79 Issue 1 Pages
38-39
Published: January 25, 2005
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
2005 Volume 79 Issue 1 Pages
40-
Published: January 25, 2005
Released on J-STAGE: October 10, 2017
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]
Article type: Article
2005 Volume 79 Issue 1 Pages
40-41
Published: January 25, 2005
Released on J-STAGE: October 10, 2017
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[in Japanese]
Article type: Article
2005 Volume 79 Issue 1 Pages
41-42
Published: January 25, 2005
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[in Japanese]
Article type: Article
2005 Volume 79 Issue 1 Pages
43-
Published: January 25, 2005
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
2005 Volume 79 Issue 1 Pages
43-44
Published: January 25, 2005
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
2005 Volume 79 Issue 1 Pages
44-45
Published: January 25, 2005
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[in Japanese], [in Japanese]
Article type: Article
2005 Volume 79 Issue 1 Pages
45-
Published: January 25, 2005
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[in Japanese]
Article type: Article
2005 Volume 79 Issue 1 Pages
46-
Published: January 25, 2005
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[in Japanese]
Article type: Article
2005 Volume 79 Issue 1 Pages
46-48
Published: January 25, 2005
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[in Japanese]
Article type: Article
2005 Volume 79 Issue 1 Pages
48-49
Published: January 25, 2005
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]
Article type: Article
2005 Volume 79 Issue 1 Pages
49-
Published: January 25, 2005
Released on J-STAGE: October 10, 2017
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[in Japanese]
Article type: Article
2005 Volume 79 Issue 1 Pages
50-
Published: January 25, 2005
Released on J-STAGE: October 10, 2017
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[in Japanese]
Article type: Article
2005 Volume 79 Issue 1 Pages
50-51
Published: January 25, 2005
Released on J-STAGE: October 10, 2017
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