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Volume 80, Issue 11
Displaying 1-11 of 11 articles from this issue
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Haruhito Tsuge, Tatsuzo Oka, Ayumi Fukuda, Youji TachibanaArticle type: Article
2006 Volume 80 Issue 11 Pages 537-542
Published: November 25, 2006
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSFrom epidemiological studies, it has been reported that cancer patients show a tendency to be vitamin B_6 (B_6) deficiency; and also that the presence of an appropriate concentration of vitamin B_6-derivatives, such as PN, PL and PLP, suppresses the proliferation of tumor cells. To maintain the cellular concentration of B_6 derivatives, pyridoxal 5'-β-D-glucoside (PL-5'β-Glc) or pyridoxal 5'-β-D-galactoside (PL-5'β-Gal), which are easily absorbed into body fluid but not easily metabolized, were synthesized. We tested whether they could suppress the proliferation of a feline mammary tumor FRM cell line. Pyridoxal 5'β-tetra-O-acetyl galactoside (PL-5'β-tetra-O-acetyl-Gal) was the most effective candidate as an inhibitor for tumor cell proliferation; the compound was sufficient to inhibit cell proliferation at 0.1 mM concentration for 5 days.View full abstractDownload PDF (790K) -
Yoshinori ItokawaArticle type: Article
2006 Volume 80 Issue 11 Pages 543-548
Published: November 25, 2006
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESS1) Recent nutritional status of B group vitamins and minerals in Japanese estimated by intake amounts. Nutritionally insufficient population for B group vitamins and minerals was estimated using Estimated Average Requirements in Dietary Reference Intakes (2005) and National Health and Nutrition Survey in Japan (2003). In 30〜49 years old male and female, ratio of insufficient populations were high in thiamin, riboflavin, pyridoxine, calcium, magnesium and iron (female only). 2) Relationship between thiamin and magnesium Experiments for investigating thiamin metabolism in magnesium deficient rats were carried out, and following results were obtained: Blood serotonin levels increased markedly in thiamin supplemented magnesium deficient groups rather than thiamin- and magnesium-deficient group. Magnesium levels in blood and bone decreased markedly in thiamin supplemented magnesium deficient groups but not in the thiamin- and magnesium-deficient group. Thiamin levels in the sciatic nerve, liver, kidney of magnesium deficient rats was lower than that in the magnesium sufficient rats. The decrease in thiamin was not detected in the central nervous system of magnesium deficient rats. With either oral or parenteral administration of thiamin, thiamin content in the heart, liver, and kidneys decreased at the same level in magnesium deficient rats. All changes in symptoms seen in magnesium deficient rats were alleviated when the animals were also deficient in thiamin. These results suggest that thiamin receptors in tissues, except central nervous system, require magnesium. 3) Relationship between thiamin and calcium When pigeons are fed with a diet of polished rice for 20〜25 days, typical opistothonus-like convulsion occurs. In convulsive pigeons, a significant decrease of thiamin and calcium in the central nervous system rather than in peripheral nervous system was observed. When calcium was added to the polished rice, convulsion never occurred. Thiamin and calcium concentrations in brain of pigeons fed polished rice with the addition of calcium were significantly higher than convulsive pigeons. It is assumed that thiamin receptor of central nervous system which play an important role in nervous functions may require calcium as a cofactor. 4) A brief review of literatures concerning nutritional correlation between B group vitamins and minerals are included.View full abstractDownload PDF (756K) -
Hiromu SakuraiArticle type: Article
2006 Volume 80 Issue 11 Pages 549-554
Published: November 25, 2006
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDiabetes mellitus (DM), which develops many secondary complications, is mainly classified as either insulin-dependent type 1 or non-insulin-dependent type 2. Several types of insulin preparations for type 1 DM and those of synthetic pharmaceuticals have been clinically used; however, those have some problems such as physical and mental pain due to daily insulin injections and defects such as side effects due to toxicity, respectively. To develop new types of pharmaceuticals, metallocomplexes containing vanadium and zinc ions were prepared to treat not only both types of experimental DM but also metabolic syndromes in animals such as obese and hypertension. In this article, the current state of development in our research group on insulin-mimetic vanadium and zinc complexes with different coordination environments is reviewed.View full abstractDownload PDF (839K) -
[in Japanese], [in Japanese]Article type: Article
2006 Volume 80 Issue 11 Pages 555-556
Published: November 25, 2006
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (309K) -
[in Japanese], [in Japanese]Article type: Article
2006 Volume 80 Issue 11 Pages 557-558
Published: November 25, 2006
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (254K) -
[in Japanese]Article type: Article
2006 Volume 80 Issue 11 Pages 559-561
Published: November 25, 2006
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (484K) -
[in Japanese], [in Japanese]Article type: Article
2006 Volume 80 Issue 11 Pages 563-
Published: November 25, 2006
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (193K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...Article type: Article
2006 Volume 80 Issue 11 Pages 563-564
Published: November 25, 2006
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (344K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...Article type: Article
2006 Volume 80 Issue 11 Pages 564-565
Published: November 25, 2006
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (365K) -
[in Japanese]Article type: Article
2006 Volume 80 Issue 11 Pages 566-567
Published: November 25, 2006
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (331K) -
[in Japanese]Article type: Article
2006 Volume 80 Issue 11 Pages 567-
Published: November 25, 2006
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (169K)
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