All issues
Volume 83, Issue 5-6
Displaying 1-41 of 41 articles from this issue
- |<
- <
- 1
- >
- >|
-
Etsuo Niki, Kouichi AbeArticle type: Article
2009 Volume 83 Issue 5-6 Pages 229-247
Published: June 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSIt is now accepted that lipid peroxidation is involved in the pathogenesis of various disorders and diseases and that vitamin E acts as a potent antioxidant against lipid peroxidation. However, the prospective randomized clinical trials have not shown consistently the beneficial effects of vitamin E on the prevention of diseases. To the contrary, meta-analysis of these studies suggests vitamin E supplementation at high doses may increase mortality. The results of these studies and possible problems are discussed. In order to provide sound scientific evidence for the effects of vitamin E, it is essential to carry out carefully-planned intervention study and to assess the effects continuously with appropriate biomarkers, not by single end point.View full abstractDownload PDF (2273K) -
[in Japanese]Article type: Article
2009 Volume 83 Issue 5-6 Pages 249-
Published: June 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (189K) -
Atsuo Kondo, Ikuyo Okai, Chisa Hayakawa, Yoichi ShimosugaArticle type: Article
2009 Volume 83 Issue 5-6 Pages 250-255
Published: June 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSWe have been assessing awareness of a role of folic acid, intake of folate supplements and dietary folate consumption among pregnant women during the past 6 years. A total of 6902 pregnant women responded to our questionnaires distributed from 2002 to 2007. Dietary folate was measured by analyzing food records completed by 441 pregnant women from 2003 to 2007. Rates of awareness and rates of folate supplementation were considerably low, 15% and 9%, respectively, in 2002, but increased year after year to 39% and 43%, respectively, in 2007. Of the 441 pregnant women who reported their food records 150 (34%) simultaneously took folate supplements. Although the amount of dietary folate consumed averaged 336μg/day in all the women, 126 women in the 1^<st> trimester consumed only 283μg/day, 120μg less than what was recommended by the Government. It was further observed that 61% of the women in the 1^<st> trimester neither consumed 400μg of dietary folate nor took folate supplements suggesting that the majority of the women were facing a real risk of conceiving fetuses afflicted with neural tube defects. Following strategies seem necessary to suppress incidence of neural tube defects in Japan: First, importance of folate supplementation should be stressed in a booklet for pregnant women. Second, the Government should repeatedly send folate information in relation to developing fetuses to the general public. Third, folate information should be given to young girls at curriculums of the junior and senior high school. Fourth, folate supplements should be given free for those women who wish to conceive. Finally, implementation of food fortification with folic acid should be seriously considered by the Government.View full abstractDownload PDF (774K) -
Tsuneo TakahashiArticle type: Article
2009 Volume 83 Issue 5-6 Pages 256-258
Published: June 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESS"Guideline for Obstetrical Practice in Japan 2008" was published under the joint edition and supervision of Japan Society of Obstetrics and Gynecology, and Japan Association of Obstetricians and Gynecologists in April 2008. It includes the item about Neural Tube Defects (NTDs) and folic acid supplementation. This guideline is composed of a Clinical Question and several Answers. The Question regarding folic acid is "If you are asked about relationship between NTDs and folic acid, what do you explain?" The answers are as follows. 1. Explanation is the following. (Recommendation Level B) 1) Periconceptional supplementation of 0.4mg folic acid per day is expected to reduce the incidence of NTDs. 2) If women with a previous child with NTD take 4mg folic acid (or one 5 mg-tablet) per day prior to conception under the supervision of a doctor, the reduction for recurrence of affected infants is expected. I hope this guideline will contribute to increasing the folic acid supplementation in women of reproductive potential. This guideline will be revised every 3 years.View full abstractDownload PDF (448K) -
Fumiki HiraharaArticle type: Article
2009 Volume 83 Issue 5-6 Pages 259-263
Published: June 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSA number of epidemiological studies have shown that supplementation or food fortification with folic acid would reduce the incidence of neural tube defects (NTDs). In 2000, Japan Ministry of health, labor and welfare issued the governmental policy of pre- and peri-conceptional folate intake (400ug/day) in women of reproductive age in order to reduce the risk of NTD affected pregnancies. Recent in vitro and in vivo studies have analyses the molecular mechanisms of folate metabolism but the morphologic development of human neural tube is poorly understood. A number of studies analyzing MTHFR variants have resulted in positive associations with increased NTD risk, suggesting that these variants may contribute to the etiology of NTDs. It makes some sense for prospective parents to be tested for MTHFR variants, or for variants of other known folate pathway genes. In addition to the protective effects of Birth Defects, folate is recommended for all generation to promote health care in particulaly to prevent cardiovascular diseaseView full abstractDownload PDF (613K) -
Mami Hiraoka, Mitsuyo Kageyama, Mayumi Yurimoto, Yoshiko Kontai, Yutak ...Article type: Article
2009 Volume 83 Issue 5-6 Pages 264-274
Published: June 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSElevated serum total homocysteine (tHcy) levels are associated with increased risk for cardiovascular disease and dementia, which can be influenced by folate status and polymorphisms in folate-metabolizing gene, especially methylenetetrahydrofolate reductase (MTHFR) C677T. This risk was successfully corrected by taking 400μg/d of folate. To prevent these diseases personalized health promotion through folate status was carried out with the genotype announcement in the "Sakado Folate Projects". The folate intake of 400μg/d above the current RDA (240μg/d) was recommended for the subjects with MTHFR TT. Serum folate levels were significantly increased and serum tHcy levels were significantly decreased during 4 months our nutritional intervention, particularly in the subjects with MTHFR TT. The frequency of intake of "green leaf vegetables" which were rich in folate and the fortification foods such as "Sakado folate bread" were increased. This nutritional intervention based on personalized nutrition by genotype announcement was effective on behavioral change in the clients and improvement of nutrition status.View full abstractDownload PDF (1630K) -
Takuya MatsuoArticle type: Article
2009 Volume 83 Issue 5-6 Pages 275-284
Published: June 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSA total of 1,162 students were surveyed regarding their awareness of folic acid using a set of questionnaires before and after the lecture (before the lecture: 4-choice selection system and description, after the lecture: 5-choice selection system and description). After the lecture, there were a significant increases (p<0.05) in the percentages of students who chose answers indicating awareness of the following folic acid-related terms and concepts compared to the baseline values (pre- vs. post-lecture values in parentheses): folic acid (45.4 vs. 93.9%), neural tube defects (16.3 vs. 87.3%), and the relation of folic acid with neural tube defects (9.2 vs. 84.1%). The response rates for a question regarding advice to others with free description (11.4 vs. 47.8%) suggested that the lecture was effective in improving students' awareness of folic acid.View full abstractDownload PDF (1414K) -
Hajime Furusawa, Yasunori Sato, Yasukazu Tanaka, Yoko Inai, Akiko Aman ...Article type: Article
2009 Volume 83 Issue 5-6 Pages 285-287
Published: June 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (443K) -
Shin-ichi Nagaoka, Akiko Fujii, Megumi Hino, Mai Takemoto, Misaki Yasu ...Article type: Article
2009 Volume 83 Issue 5-6 Pages 288-289
Published: June 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (179K) -
Dan Sato, Wataru Yamagata, Shigeharu Harada, Tomoyoshi NozakiArticle type: Article
2009 Volume 83 Issue 5-6 Pages 290-293
Published: June 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (549K) -
Kazuhiro YamadaArticle type: Article
2009 Volume 83 Issue 5-6 Pages 294-296
Published: June 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (546K) -
Hideyuki HayashiArticle type: Article
2009 Volume 83 Issue 5-6 Pages 297-299
Published: June 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (396K) -
Tomohiro YanoArticle type: Article
2009 Volume 83 Issue 5-6 Pages 300-301
Published: June 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (269K) -
Daigo Homma, Hiroshi IchinoseArticle type: Article
2009 Volume 83 Issue 5-6 Pages 302-304
Published: June 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (403K) -
[in Japanese], [in Japanese], [in Japanese]Article type: Article
2009 Volume 83 Issue 5-6 Pages 305-
Published: June 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (213K) -
[in Japanese]Article type: Article
2009 Volume 83 Issue 5-6 Pages 305-306
Published: June 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (364K) -
[in Japanese], [in Japanese]Article type: Article
2009 Volume 83 Issue 5-6 Pages 306-307
Published: June 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (389K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...Article type: Article
2009 Volume 83 Issue 5-6 Pages 307-308
Published: June 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (406K) -
[in Japanese], [in Japanese], [in Japanese]Article type: Article
2009 Volume 83 Issue 5-6 Pages 308-309
Published: June 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (405K) -
[in Japanese]Article type: Article
2009 Volume 83 Issue 5-6 Pages 309-
Published: June 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (231K) -
[in Japanese], [in Japanese], [in Japanese]Article type: Article
2009 Volume 83 Issue 5-6 Pages 309-310
Published: June 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (394K) -
[in Japanese], [in Japanese]Article type: Article
2009 Volume 83 Issue 5-6 Pages 310-311
Published: June 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (357K) -
[in Japanese]Article type: Article
2009 Volume 83 Issue 5-6 Pages 311-
Published: June 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (189K) -
[in Japanese]Article type: Article
2009 Volume 83 Issue 5-6 Pages 312-
Published: June 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (218K) -
[in Japanese]Article type: Article
2009 Volume 83 Issue 5-6 Pages 312-313
Published: June 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (384K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...Article type: Article
2009 Volume 83 Issue 5-6 Pages 313-314
Published: June 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (328K) -
[in Japanese]Article type: Article
2009 Volume 83 Issue 5-6 Pages 315-
Published: June 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (94K) -
[in Japanese], [in Japanese]Article type: Article
2009 Volume 83 Issue 5-6 Pages 316-317
Published: June 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (401K) -
[in Japanese]Article type: Article
2009 Volume 83 Issue 5-6 Pages 317-
Published: June 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (222K) -
[in Japanese]Article type: Article
2009 Volume 83 Issue 5-6 Pages 317-320
Published: June 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (732K) -
[in Japanese]Article type: Article
2009 Volume 83 Issue 5-6 Pages 321-322
Published: June 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (397K) -
[in Japanese]Article type: Article
2009 Volume 83 Issue 5-6 Pages 322-323
Published: June 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (392K) -
[in Japanese]Article type: Article
2009 Volume 83 Issue 5-6 Pages 323-
Published: June 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (223K) -
[in Japanese]Article type: Article
2009 Volume 83 Issue 5-6 Pages 324-325
Published: June 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (345K) -
[in Japanese]Article type: Article
2009 Volume 83 Issue 5-6 Pages 326-
Published: June 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (65K) -
[in Japanese], [in Japanese], [in Japanese]Article type: Article
2009 Volume 83 Issue 5-6 Pages 327-
Published: June 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (207K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...Article type: Article
2009 Volume 83 Issue 5-6 Pages 327-328
Published: June 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (372K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...Article type: Article
2009 Volume 83 Issue 5-6 Pages 328-329
Published: June 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (379K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...Article type: Article
2009 Volume 83 Issue 5-6 Pages 329-330
Published: June 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (367K) -
[in Japanese]Article type: Article
2009 Volume 83 Issue 5-6 Pages 330-
Published: June 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (210K) -
Article type: Bibliography
2009 Volume 83 Issue 5-6 Pages 331-336
Published: June 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (640K)
- |<
- <
- 1
- >
- >|