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Volume 73, Issue 9
Displaying 1-22 of 22 articles from this issue
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Sachiko YAMADA, Keiko YAMAMOTO, Hiroyuki MASUNO, Masato SHIMIZUArticle type: Article
1999 Volume 73 Issue 9 Pages 511-525
Published: September 25, 1999
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSOn the basis of conformational analysis of the side chain of 1, 25-(OH)_2D_3 (1) and its 20-epimer (2), we grouped region in space, where the side chain of these vitamin D can move about, into four, A, G, EA and EG. We then designed and synthesized analogs whose side chain mobility is restricted in one of these four regions: four diastereomers at C-20 and -22 of 22-methyl-1, 25-(OH)_2D_3 (3〜6). We evaluated various activities of these analogs (3〜6). The results lead us to delineate space group-activity relationship. We similarly analyzed the conformation of nearly fifty highly active known vitamin D analogs and defined another space region F. The results show that our active space group concept can be applicable to almost all these side chain analogs. Altogether, the following space group-activity relationship was found: VDR affinity, EA>A>F>G>EG; DBP affinity, A only; Cell differentiation, EA>F>A>EG and G; Calcemic, EA>A and G>F>EG.View full abstractDownload PDF (1258K) -
Katsumi SHIBATA, Shin-Ichi FUKUOKA, Masumi OKUMURA, Tsutomu FUKUWATARI ...Article type: Article
1999 Volume 73 Issue 9 Pages 527-532
Published: September 25, 1999
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSQuinolinic acid, a key intermediate in the de novo biosynthesis of niacin, is biosynthesized from L-tryptophan in mammals while it is biosynthesized from L-aspartic acid and dihydroxyacetone phosphate in Escherichia coil. Quinolinate synthetase of E. coli consists of two components A and B proteins. The B protein has been identified as L-aspartic acid oxidase that generates iminoaspartic acid. Iminoaspartic acid is then conjugated with dihydroxyacetone phosphate to generate quinolinic acid by the A protein. In the mammalian liver, unlike in E. coli, D-aspartic acid oxidase has been found, by which also iminoaspartic acid is generated. Significant amounts of D-aspartic acid are contained in tortillas (lime-treated corn) which has been served as anti-pellagra foodstuff. Therefore, we postulated and examined a possibility of the biosynthesis of niacin from D-aspartic acid in mammals. Administration of D-aspartic acid to rats and humans did not increase urinary excretion of niacin and its metabolites. In rats, administration of D-aspartic acid did not improve the growth of weaning rats fed a tryptophan-limiting and niacin free diet. Based on those results, the possibility of biosynthesis of niacin from D-aspartic acid in mammals was denied.View full abstractDownload PDF (648K) -
[in Japanese]Article type: Article
1999 Volume 73 Issue 9 Pages 533-537
Published: September 25, 1999
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (505K) -
[in Japanese]Article type: Article
1999 Volume 73 Issue 9 Pages 539-544
Published: September 25, 1999
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (650K) -
[in Japanese], [in Japanese]Article type: Article
1999 Volume 73 Issue 9 Pages 545-549
Published: September 25, 1999
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (862K) -
[in Japanese]Article type: Article
1999 Volume 73 Issue 9 Pages 551-559
Published: September 25, 1999
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (605K) -
[in Japanese]Article type: Article
1999 Volume 73 Issue 9 Pages 561-566
Published: September 25, 1999
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (826K) -
[in Japanese]Article type: Article
1999 Volume 73 Issue 9 Pages 567-568
Published: September 25, 1999
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (280K) -
[in Japanese]Article type: Article
1999 Volume 73 Issue 9 Pages 568-570
Published: September 25, 1999
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (429K) -
[in Japanese], [in Japanese]Article type: Article
1999 Volume 73 Issue 9 Pages 570-571
Published: September 25, 1999
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (324K) -
[in Japanese], [in Japanese]Article type: Article
1999 Volume 73 Issue 9 Pages 571-574
Published: September 25, 1999
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (551K) -
[in Japanese], [in Japanese]Article type: Article
1999 Volume 73 Issue 9 Pages 574-576
Published: September 25, 1999
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (447K) -
[in Japanese], [in Japanese]Article type: Article
1999 Volume 73 Issue 9 Pages 576-577
Published: September 25, 1999
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (307K) -
[in Japanese]Article type: Article
1999 Volume 73 Issue 9 Pages 579-580
Published: September 25, 1999
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (227K) -
[in Japanese], [in Japanese], [in Japanese]Article type: Article
1999 Volume 73 Issue 9 Pages 581-
Published: September 25, 1999
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (141K) -
[in Japanese], [in Japanese], R. Pittelkow M.Article type: Article
1999 Volume 73 Issue 9 Pages 581-
Published: September 25, 1999
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (141K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...Article type: Article
1999 Volume 73 Issue 9 Pages 582-
Published: September 25, 1999
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (182K) -
[in Japanese]Article type: Article
1999 Volume 73 Issue 9 Pages 582-583
Published: September 25, 1999
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (305K) -
[in Japanese], [in Japanese]Article type: Article
1999 Volume 73 Issue 9 Pages 583-584
Published: September 25, 1999
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (212K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese]Article type: Article
1999 Volume 73 Issue 9 Pages 585-
Published: September 25, 1999
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (154K) -
[in Japanese], [in Japanese], [in Japanese]Article type: Article
1999 Volume 73 Issue 9 Pages 586-
Published: September 25, 1999
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (183K) -
[in Japanese], [in Japanese], [in Japanese]Article type: Article
1999 Volume 73 Issue 9 Pages 586-587
Published: September 25, 1999
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (232K)
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