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Volume 77, Issue 8
Displaying 1-15 of 15 articles from this issue
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Hiroyasu INOUEArticle type: Article
2003 Volume 77 Issue 8 Pages 449-458
Published: August 25, 2003
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSCyclooxygenase-2 (COX-2), a rate-limiting enzyme for prostaglandins (PG) synthesis, plays a key role in inflammation, tumorigenesis, development and circulatory homeostasis. The PGD_2 metabolite 15-deoxy-Δ^<12,14>PGJ_2 (15d-PGJ_2) was identified as a potent natural ligand for the peroxisome proliferatoractivated receptor-γ (PPARγ). 15d-PGJ_2 suppresses the lipopolysaccharide (LPS)-induced expression of COX-2 in the macrophage-like differentiated U937 cells, but not in vascular endothelial cells. PPARγmRNA expressed abundantly in the U937 cells is down-regulated by LPS. In contrast, LPS up-regulates mRNA for the glucocorticoid receptor, and its ligand dexamethasone (DEX) strongly suppresses the LPS-induced expression of COX-2 gene. Transfection of a PPARy-expression vector into the endothelial cells acquires this suppressive regulation of COX-2 gene transcription by 15d-PGJ_2, but not by DEX. Taken together, we propose that expression of COX-2 will be regulated by a negative feedback loop mediated through PPARγ, which makes possible a dynamic production of PG, especially in macrophages, and may attribute to various expression patterns and physiological functions of COX-2.View full abstractDownload PDF (1031K) -
[in Japanese]Article type: Article
2003 Volume 77 Issue 8 Pages 459-460
Published: August 25, 2003
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (252K) -
[in Japanese]Article type: Article
2003 Volume 77 Issue 8 Pages 461-463
Published: August 25, 2003
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (440K) -
[in Japanese]Article type: Article
2003 Volume 77 Issue 8 Pages 463-465
Published: August 25, 2003
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (380K) -
[in Japanese], [in Japanese], [in Japanese]Article type: Article
2003 Volume 77 Issue 8 Pages 465-470
Published: August 25, 2003
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (892K) -
[in Japanese], [in Japanese]Article type: Article
2003 Volume 77 Issue 8 Pages 470-473
Published: August 25, 2003
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (565K) -
[in Japanese]Article type: Article
2003 Volume 77 Issue 8 Pages 473-474
Published: August 25, 2003
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (257K) -
Article type: Appendix
2003 Volume 77 Issue 8 Pages 475-
Published: August 25, 2003
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (40K) -
[in Japanese]Article type: Article
2003 Volume 77 Issue 8 Pages 476-
Published: August 25, 2003
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (185K) -
[in Japanese]Article type: Article
2003 Volume 77 Issue 8 Pages 476-477
Published: August 25, 2003
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (301K) -
[in Japanese]Article type: Article
2003 Volume 77 Issue 8 Pages 477-478
Published: August 25, 2003
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (294K) -
[in Japanese]Article type: Article
2003 Volume 77 Issue 8 Pages 478-480
Published: August 25, 2003
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (412K) -
[in Japanese], [in Japanese], [in Japanese]Article type: Article
2003 Volume 77 Issue 8 Pages 480-481
Published: August 25, 2003
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (300K) -
[in Japanese]Article type: Article
2003 Volume 77 Issue 8 Pages 481-482
Published: August 25, 2003
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (294K) -
[in Japanese]Article type: Article
2003 Volume 77 Issue 8 Pages 482-483
Published: August 25, 2003
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (325K)
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