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Volume 86, Issue 3
Displaying 1-20 of 20 articles from this issue
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Kohta Ohnishi, Kazuhiro Irie, Akira MurakamiArticle type: Article
2012 Volume 86 Issue 3 Pages 133-141
Published: March 25, 2012
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSPlants synthesize various secondary metabolites which play crucial roles in their adaptation to environmental stresses. These phytochemicals have been clarified to possess potentials for regulating mammalian physiological functions. Recently, their target molecules in mammals have been intensively studied. Zerumbone, a sesquiterpene occurring in Zingiber zerumbet Smith, is a promising chemopreventive agent which has various bioactivities including anti-inflammatory and detoxifying effects. This phytochemical suppresses the expression of cyclooxygenase-2 via a post-transcriptional mechanism and induces phase 2 detoxification enzymes. Our in vitro study with zerumbone-bound Sepharose revealed that it covalently binds to AU-rich element-binding proteins and Kelch-like ECH-associated protein 1 which are essential for those bioactivities. This review article describes versatile bioactivities of zerumbone, and highlights its target molecules.View full abstractDownload PDF (1043K) -
Ryoji FujikiArticle type: Article
2012 Volume 86 Issue 3 Pages 142-154
Published: March 25, 2012
Released on J-STAGE: October 10, 2017
JOURNAL RESTRICTED ACCESSFat-soluble vitamins A and D are essential for many biological processes in a wide variety of cell types. These actions are exerted by their cognate nuclear receptors (NRs), vitamin A receptor (RAR) and vitamin D receptor (VDR), respectively. Although the molecular basis of NR-mediated transcription has been established, the regulations of the spatiotemporal target genes are not well known. Recently, we have identified the novel co-regulator complexes responsible for NR-mediated transcription. And, we also found that most of them were involved in chromatin reorganization on the promoters. Herein, I report the molecular mechanisms of cell-specific chromatin remodeling in the VDR-mediated transrepression of 25-hydroxyvitamin D_3-1α-hydroxylase [1α(OH)ase] by WSTF, an ATP-dependent chromatin remodeling factor, and RAR-mediated epigenetic regulation through O-linked N-acetylglucosamin signaling during HL60 differentiation. These studies would help our understanding a basic mechanism how tissue-specific regulations of NR target genes were achieved.View full abstractDownload PDF (24546K) -
Taro Murakami, Tetsuo YamanoArticle type: Article
2012 Volume 86 Issue 3 Pages 155-162
Published: March 25, 2012
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSBiotin, a form of vitamin B, acts as a coenzyme in carboxylation reactions, which are involved in gluconeogenesis, amino acid catabolism, and fatty acid synthesis. Biotin is contained in widely various foods such as chicken eggs, which is a major source of biotin intake. However, raw egg is known to contain several biotin-binding proteins, such as avidin in egg white, which makes biotin nutritionally unavailable. We applied an in vitro digestion model to evaluate the amount of biologically accessible biotin in foods prepared with eggs. A broad range of bioaccessibility values was found among foods prepared with different cooking processes. The denaturalization of biotin binding proteins in egg, especially avidin in egg white, apparently plays an important role in the digestion and absorption of biotin from foods.View full abstractDownload PDF (8039K) -
Yoko Yamashita, Norio Yamamoto, Hitoshi AshidaArticle type: Article
2012 Volume 86 Issue 3 Pages 163-173
Published: March 25, 2012
Released on J-STAGE: October 10, 2017
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Saiko Ikeda, Saki NomuraArticle type: Article
2012 Volume 86 Issue 3 Pages 174-176
Published: March 25, 2012
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (382K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...Article type: Article
2012 Volume 86 Issue 3 Pages 177-
Published: March 25, 2012
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (169K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese]Article type: Article
2012 Volume 86 Issue 3 Pages 177-178
Published: March 25, 2012
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (309K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...Article type: Article
2012 Volume 86 Issue 3 Pages 178-179
Published: March 25, 2012
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (345K) -
[in Japanese], Angsuma Wongmayura, [in Japanese], [in Japanese], [in J ...Article type: Article
2012 Volume 86 Issue 3 Pages 179-180
Published: March 25, 2012
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (356K) -
[in Japanese]Article type: Article
2012 Volume 86 Issue 3 Pages 180-181
Published: March 25, 2012
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (351K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...Article type: Article
2012 Volume 86 Issue 3 Pages 181-182
Published: March 25, 2012
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (349K) -
[in Japanese]Article type: Article
2012 Volume 86 Issue 3 Pages 182-
Published: March 25, 2012
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (204K) -
[in Japanese]Article type: Article
2012 Volume 86 Issue 3 Pages 182-183
Published: March 25, 2012
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (263K) -
[in Japanese], [in Japanese], [in Japanese]Article type: Article
2012 Volume 86 Issue 3 Pages 184-185
Published: March 25, 2012
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (344K) -
[in Japanese], [in Japanese], [in Japanese], Puspo Edi Giriwono, [in J ...Article type: Article
2012 Volume 86 Issue 3 Pages 185-186
Published: March 25, 2012
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (362K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese]Article type: Article
2012 Volume 86 Issue 3 Pages 186-187
Published: March 25, 2012
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (362K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...Article type: Article
2012 Volume 86 Issue 3 Pages 187-188
Published: March 25, 2012
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (367K) -
[in Japanese]Article type: Article
2012 Volume 86 Issue 3 Pages 188-189
Published: March 25, 2012
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (365K) -
[in Japanese], [in Japanese]Article type: Article
2012 Volume 86 Issue 3 Pages 189-
Published: March 25, 2012
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (204K) -
Article type: Bibliography
2012 Volume 86 Issue 3 Pages 190-194
Published: March 25, 2012
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (477K)
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