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Hiroyuki Arai
Article type: Article
2012 Volume 86 Issue 10 Pages
529-538
Published: October 25, 2012
Released on J-STAGE: October 10, 2017
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Vitamin E is the most important lipid-soluble antioxidant in humans. Vitamin E occurs in nature in eight different forms: α-, β-, γ-, δ-tocopherols and -tocotrienols. Although we intake daily diets containing these vitamin E isoforms, our bodies are enriched with only α-tocopherol. This biological discrimination occurs not at the stage of absorption in the intestine but at the stage of secretion from the liver. We isolated a cytosolic protein that specifically binds α-tocopherol and transfers it between separate membranes, and named it α-tocopherol transfer protein (α-TTP). Moreover, we demonstrated that the α-TTP gene is mutated in the patients with familial vitamin E deficiency. To date, about 20 different mutations were identified from the genes of the patients. α-TTP knockout mice were also established and served as a good model for human patients with familial vitamin E deficiency. More attention has been paid to the biological importance of vitamin-E through the studies with vitamin E-deficient patients and mice.
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Tomohiko Ohno, Yohei Shirakami, Masahito Shimizu, Masaya Kubota, Hiroy ...
Article type: Article
2012 Volume 86 Issue 10 Pages
539-541
Published: October 25, 2012
Released on J-STAGE: October 10, 2017
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Mamoru Nishimuta
Article type: Article
2012 Volume 86 Issue 10 Pages
542-543
Published: October 25, 2012
Released on J-STAGE: October 10, 2017
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New food composition tables named "Standard Tables of Food Composition in Japan (2010)" were published in 2010. In these tables, a water soluble vitamin, biotin, and four trace elements, chromium, molybdenum, selenium, and iodine were newly included. These data base gave us an opportunity to investigate the relationships between these nutrients and health and diseases. The author expects that an efficient use of this new device produces studies associated with the development of life sciences.
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Momoko Chiba
Article type: Article
2012 Volume 86 Issue 10 Pages
544-547
Published: October 25, 2012
Released on J-STAGE: October 10, 2017
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Chromium (Cr) is an essential trace element, and works in the metabolisms of glucose, protein, and lipid. Recommended dietary allowance of Cr is as follows: 40 μg/day for males and 30μg/day for female at the age of 18 to 69 years; 35μg/day for males and 25μg/day for females at the age of more than 70. These values have been estimated from the amount of energy consumed by body activity. As to the adequate intake of Cr for infants, 0.8μg/day is required for 0- to 5-months-old infants (both sexes), and 1.0 μg/day is required for 6- to 11-months-old infants (both sexes).
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Munehiro Yoshida
Article type: Article
2012 Volume 86 Issue 10 Pages
548-557
Published: October 25, 2012
Released on J-STAGE: October 10, 2017
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The physiological functions of selenium and molybdenum and the range of their adequate intake have been described. Dietary selenium is incorporated to selenocysteine residues in selenoprotein via a unique metabolic process and manifests several physiological functions. Twenty-five species of selenoproteins including glutathione peroxidase family have been identified by genome analysis in humans. The range of adequate intake of selenium is estimated to be 50 to 250 μg/day. Since most Japanese people take selenium at about 100 μg/day mainly from fishes and shells, meats and eggs and wheat products, they should not take additional selenium in a supplement form. Molybdenum exists in three molybdoenzymes and functions as a cofactor for the enzymes. Since a congenital deficiency of molybdoenzymes is fatal, molybdenum is assumed to be an essential trace element. The range of adequate intake of molybdenum is estimated to be 25 to 1000 μg/day. Most Japanese people take molybdenum at the amount of 150 to 350 μg/day mainly from cereals and beans. It is possible to calculate the daily intake amounts of selenium and molybdenum from daily menu using the Standard Tables of Food Composition in Japan 2010 because the calculated values were close to the chemically analyzed values.
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Yasuyuki Muramatsu
Article type: Article
2012 Volume 86 Issue 10 Pages
558-561
Published: October 25, 2012
Released on J-STAGE: October 10, 2017
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Iodine is known to be accumulated in marine organisms. In human body, this element is concentrated in the thyroid gland and plays an important role in controlling its metabolism. We have analyzed iodine concentrations in different food materials, with a special reference to seaweeds. Laminaria (Konbu-algae) was found to contain a very high concentration of iodine (1500-3300 ppm, on a dry weight basis), suggesting a significant contributor to dietary intake of this element. Solubility of iodine from dried Konbu was studied and found that about 80% of iodine was dissolved in water. Iodine concentration in human milk was also determined and the concentration was in the range of 0.08-7.0 mg/L. High iodine concentrations in the milk were derived from a high consumption of Konbu by nursing mother. The average dietary consumption of iodine in Japan was estimated as 1.1mg/day. Release of radioiodine at the accident of Fukushima Daiichi Power plant was also discussed.
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Mio Kioka, Toshiaki Watanabe
Article type: Article
2012 Volume 86 Issue 10 Pages
562-568
Published: October 25, 2012
Released on J-STAGE: October 10, 2017
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Biotin is only a vitamin in 5 micronutrients that were newly collected in the Standard Tables of Food Composition in Japan in 2010. The recommended dietary intake amount of biotin has been set to be 30 μg/day by the Recommended Dietary Allowances for Japanese 6th Revision in 2000. The adequate intake amounts of biotin set by the Dietary Reference Intakes 2005 and 2010 are 45 and 50 μg/day, respectively. However, biotin had not been included in the Standard Tables of Food Composition in Japan. Thus, there is little evidence concerning the dietary intake of biotin. Herein, we will review the fundamental aspects and physiological roles of biotin, comparison of analytical methods for biotin, and precautions of using the Standard Tables of Food Composition for biotin.
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Shoko Sato, Hitoshi Shirakawa
Article type: Article
2012 Volume 86 Issue 10 Pages
569-572
Published: October 25, 2012
Released on J-STAGE: October 10, 2017
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Ikuo Yoshimura
Article type: Article
2012 Volume 86 Issue 10 Pages
573-577
Published: October 25, 2012
Released on J-STAGE: October 10, 2017
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
2012 Volume 86 Issue 10 Pages
578-579
Published: October 25, 2012
Released on J-STAGE: October 10, 2017
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
2012 Volume 86 Issue 10 Pages
579-
Published: October 25, 2012
Released on J-STAGE: October 10, 2017
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
2012 Volume 86 Issue 10 Pages
579-580
Published: October 25, 2012
Released on J-STAGE: October 10, 2017
JOURNAL
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
2012 Volume 86 Issue 10 Pages
580-581
Published: October 25, 2012
Released on J-STAGE: October 10, 2017
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[in Japanese]
Article type: Article
2012 Volume 86 Issue 10 Pages
581-582
Published: October 25, 2012
Released on J-STAGE: October 10, 2017
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[in Japanese]
Article type: Article
2012 Volume 86 Issue 10 Pages
582-
Published: October 25, 2012
Released on J-STAGE: October 10, 2017
JOURNAL
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
2012 Volume 86 Issue 10 Pages
583-584
Published: October 25, 2012
Released on J-STAGE: October 10, 2017
JOURNAL
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[in Japanese]
Article type: Article
2012 Volume 86 Issue 10 Pages
584-
Published: October 25, 2012
Released on J-STAGE: October 10, 2017
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[in Japanese]
Article type: Article
2012 Volume 86 Issue 10 Pages
585-
Published: October 25, 2012
Released on J-STAGE: October 10, 2017
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Article type: Bibliography
2012 Volume 86 Issue 10 Pages
586-590
Published: October 25, 2012
Released on J-STAGE: October 10, 2017
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