The aim of present study is to investigate maternal PIVKA-PC and PIVKA-11 levels during early postpartum period and their correlation with estradiol (E_2) levels. Study subjects were 23 puerperal women without any medical complications or previous history of VTE (venous thromboembolism). Blood was sampled on the day 0, 1, and 2-3^<rd> postpartum day, and we measured protein C (PC) antigens & activity, PIVKA-PC, PIVKA-11, and E_2. The PIVKA-PC level in total PC was 10〜20% throughout the postpartum period. Compared to PIVKA-11 level, it's level was strikingly high. Moreover, significant difference in PIVKA-PC levels among delivery modes and a considerable correlation between PIVKA-PC and the declining ratio of E_2 (r=0.416) were observed. The reason for increased risk of VTE during early postpartum period remains unclear. The current study suggests that a high PIVKA-PC plays an important role in the mechanism of VTE.
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