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Volume 41 (1970)
- Issue 6 Pages 387-
- Issue 5 Pages 321-
- Issue 4 Pages 255-
- Issue 3 Pages 165-
- Issue 2 Pages 57-
- Issue 1 Pages 1-
Volume 41, Issue 4
Displaying 1-29 of 29 articles from this issue
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Yukio SUZUKI, Kei UCHIDAArticle type: Article
1970 Volume 41 Issue 4 Pages 255-259
Published: April 25, 1970
Released on J-STAGE: February 22, 2018
JOURNAL FREE ACCESSExperiments on the decomposition of riboflavin glucosyl compounds were carried out with dialyzed bran culture extracts of Aspergillus awamori, A. niger and Mucor javanicus. In A. awamori and A. niger, riboflavin-α-glucoside (B_2-gl), riboflavin isomaltoside (B_2-gl-gl) and higher members of riboflavin oligoglucosyl compound (B_2-(gl)_n) were mainly decomposed through the following route : B_2-(gl)_n→B_2-(gl)_<n-1>→………B_2-gl-gl→B_2-gl→B_2. In M. javanicus, both culture extract and its partially purified enzyme preparation attacked more powerfully the B_2(5'-1) glucose bond of riboflavin compound molecule than its glucose (6-1) glucose bond ; i.e. B_2-gl-gl→B_2+gl-gl.View full abstractDownload PDF (669K) -
Teruo FUKUDA, Kazuko MIMURAArticle type: Article
1970 Volume 41 Issue 4 Pages 260-262
Published: April 25, 1970
Released on J-STAGE: February 22, 2018
JOURNAL FREE ACCESSThe paper electrophoretic method to separate and identify twelve water-soluble vitamins (thiamine, riboflavin, pyridoxine, cyanocobalamin, nicotinic acid, nicotinamide, folic acid, p-aminobenzoic acid, pantothenic acid, biotin, flavinadenine dinucleotide, flavinmononucleotide) was investigated by using 0.5% sodium acetate, 1% sodium borate, and 0.1% ammonium chloride as electrolyte. The mobilities of the compounds were shown as the relative one to flavianic acid. As the result, it was shown that all compounds could be identified by selecting the electrolytes.View full abstractDownload PDF (340K) -
Mitsuko OKADA, Atsuko OCHIArticle type: Article
1970 Volume 41 Issue 4 Pages 266-
Published: April 25, 1970
Released on J-STAGE: February 22, 2018
JOURNAL FREE ACCESSDecreases in both soluble and mitochondrial enzyme activities in vitamin B_6-deficient rat liver were observed on alanine and aspartate amino transferases. Rat liver mitochondria subjected to both vitamin B_6-and choline-deficiency resulted in marked decrease in a respiratory control, whereas only vitamin B_6-deficiency did not altered the mitochondrial respiration. In analyses of liver mitochondrial lipids, decreases in arachidonic acid and phosphatidylethanolamine were observed in vitamin B_6-and choline-deficiencies, respectively. Low content of phosphatidylethanolamine in both vitamin B_6-and cholinedeficient rat liver might bring about an alteration to mitochodrial function.View full abstractDownload PDF (179K) -
Terumi TAMADA, Kenjiro MOMO, Setsuko KODAMA, Tsutomu IRIKURAArticle type: Article
1970 Volume 41 Issue 4 Pages 273-
Published: April 25, 1970
Released on J-STAGE: February 22, 2018
JOURNAL FREE ACCESSSignificant body weight loss was observed in rats 8 weeks after total gastrectomy. Peripheral blood from rat tail vein at this time was examined and decreases of hemoglobin, hematocrit values, plasma proteins and also marked increase of reticulocytes were observed. Especially, immature erythrocytes which were not observed in normal rats appeared in the blood of the totally gastrectomized rats. Methylcobalamin (CH_3-B_12) 50μg/100g or 250μg/100g and cyanocobalamin (CN-B_<12>) 250μg/100g were subcutaneously injected to the rats daily from 8th week till 12th week after the operation, and their effects on the agastric anemia were examined. Reticulocyte contents and plasma proteins were repaired to some extent in CH_3-B_<12> 250μg/100g treated group. CH_3-B_<12> 50μg/100g or CN-B_<12> 250μg/100g also showed a tendency of repairment, but not significantly. On immature erythrocytes, marked decreasing effects were observed in both CH_3-B_<12> and CN-B_<12> treated groups. Particularly, 250μg/100g of CH_3-B_<12> was the most effective and 50μg/100g was the second. 250μg/100g of CN-B_<12> was also significantly effective compared with the placebo control, though its effects was inferior to that of 50μg of CH_3-B_<12>.View full abstractDownload PDF (185K) -
Chikataro KAWASAKI, Masaomi KONDO, Hiroshi YOKOYAMA, Takako NITTAArticle type: Article
1970 Volume 41 Issue 4 Pages 278-
Published: April 25, 1970
Released on J-STAGE: February 22, 2018
JOURNAL FREE ACCESSDiazinothiamine (I), when 10^<-5>mole was added to the broth with 0.05μg thiamine-HCl, was shown to be inhibitory to the growth of Kl. apiculata but not to be inhibitory to that of L. fermenti. The inhibition of the yeast by (I) was recovered at the presence of 0.10μg thiamine-HCl. Pyrithiamine (II), phenylthiazinothiamine (III), triazinothiamine (IV) and desthiothiamine (V) inhibited cell-uptake of thiamine, when they were incubated with cells of Kl. apiculata or Sacch. cerevisiae and thiamine in the broth, but (I) was shown to be least inhibitory to thiamine-uptake. The antithiamine potency of (I), (IV) and (V) was estimated on thiamine-deficient rats. Oral administration of the compound (I) or (IV) simultaneously with thiamine (I : thiamine-HCl=1000 : 1,IV : thiamine-HCl=500 : 1) resulted in loss of body weights of thiaminedeficient rats. But oral administration of (V) and thiamine (V : thiamine-HCl=1000 : 1) did not cause loss of body weights.View full abstractDownload PDF (173K) -
Kikuko INOUEArticle type: Article
1970 Volume 41 Issue 4 Pages 279-280
Published: April 25, 1970
Released on J-STAGE: February 22, 2018
JOURNAL FREE ACCESSMice and rabbits were used to check the LD_<50> with O-benzoylthiamine and O-carbethoxythiamine, compared with thiamine propyldisulfide and other thiamine derivatives. O-benzoylthiamine and O-carbethoxythiamine showed stronger toxic effect than others.View full abstractDownload PDF (225K) -
Makoto FURUDATEArticle type: Article
1970 Volume 41 Issue 4 Pages 286-
Published: April 25, 1970
Released on J-STAGE: February 22, 2018
JOURNAL FREE ACCESSTo elucidate the role of fat-soluble vitamins and female sex hormones on motility of uterine muscle, their effects upon actomyosin-ATPase (E.C. 3. 6. 1. 3.) of rabbit's uterine muscle was investigated. Crude uterine actomyosin was extracted by the method of Szent-Gyorgyi from albino rabbits after administration of the vitamins and hormones and the enzymic activities were determined. The results are as follows : 1) The enzymic activity of crude uterine actomyosin of rabbit was not affected by vitamins A and E. 2) Vitamins D and K accelerated the actomyosin activity and it was more manifest by the combined use of these drugs and estrogen. But progesterone did not facilitate the activity in combined use. 3) The enzymic activity of crude uterine actomyosin was promoted by estrogen, but it was not affected by progesterone.View full abstractDownload PDF (158K) -
Yoshitomo KOCHI, Keizo NAKAMURA, Kenzo KANOTA, Takuma OBAArticle type: Article
1970 Volume 41 Issue 4 Pages 291-
Published: April 25, 1970
Released on J-STAGE: February 22, 2018
JOURNAL FREE ACCESSProton magnetic resonance and its simulation studies were performed on diacetyldehydroascorbic acid dimer and 5,6-diacetylascorbic acid. Even though great care was paid on the compas work to measure the chemical shifts and coupling constants of the compounds, some deviations were found between the observed NMR constants and the simulated values which gave spectrum similar to the observed lines. And it was concluded that a simulation procedure was indispensable to get NMR constants which fit to a theoretical treatment. The present work elucidated that the hindrance of free rotation of the carbon atoms of 5 and 6 position of 5,6-diacetylascorbic acid by neighbouring acetyl groups caused to give different vicinal coupling constants (5.45 and 9.00 Hz respectively), and the values of diacetyl dehydroascorbic acid dimer were almost similar (6.25 and 6.00 Hz, respectively), although ⊿■ of the geminal protons of the 6 position were nearly 2.5 times larger than that of 5,6-diacetylascorbic acid. The signs of the vicinal and geminal coupling constants were determined.View full abstractDownload PDF (177K) -
Yasuo KAKIUCHIArticle type: Article
1970 Volume 41 Issue 4 Pages 294-
Published: April 25, 1970
Released on J-STAGE: February 22, 2018
JOURNAL FREE ACCESSThe vitamin B_6 requirement of Saccharomyces carlsbergensis 4228 (original and serine-adapted strain) in each thiamine added medium containing alanine, serine, phenylalanine or glutamic acid and methionine as the nitrogen source was investigated. The vitamin B_6 requirement in the alanine or serine medium was significantly higher than those in the phenylalanine or glutamate-methionine medium, in correspondance with strong inhibition or no inhibition of the growth by addition of thiamine. Each vitamin B_6 requirement of the yeast in simple nitrogen source was shown to be closely related with the maximal vitamin B_6 content of the yeast cells during the growth in the medium with thiamine. These findings suggest that the growth-inhibition of the yeast by thiamine was observed, when the vitamin B_6 content of the yeast is depressed below the level corresponding to the vitamin B_6 requirement through the inhibition of vitamin B_6 biosynthesis by thiamine in the yeast cells.View full abstractDownload PDF (160K) -
Chikataro KAWASAKI, Yasuo KAKIUCHIArticle type: Article
1970 Volume 41 Issue 4 Pages 300-
Published: April 25, 1970
Released on J-STAGE: February 22, 2018
JOURNAL FREE ACCESSIt was demonstrated that thiamine, when added to the serine medium with the inoculation of serine-adapted Saccharomyces carlsbergensis 4228,was accumulated on the yeast cells to the extent over 2% of the cell weight, and the accumulation was markedly inhibited by phenylthiazinothiamine (PTT). Growth-inhibition of the yeast by addition of thiamine was not observed in the medium containing thiamine and PTT. When the cells, highly accumulated with thiamine, was inoculated in the medium containing serine and no thiamine, the yeast showed retarded growth. The rate of phosphorylation of thiamine in the fast-growing cells was shown to be higher than that in the delayed ones during the growth of both the original strain and its serine-adapted strain. These findings suggest that the thiamine abundantly accumulated in the yeast cells, plays an important role in the growth-inhibition of the yeast, and thiamine diphosphate in the yeast cells seems to stimulate the growth rather than inhibition.View full abstractDownload PDF (170K) -
[in Japanese]Article type: Article
1970 Volume 41 Issue 4 Pages 301-302
Published: April 25, 1970
Released on J-STAGE: February 22, 2018
JOURNAL FREE ACCESSDownload PDF (307K) -
[in Japanese]Article type: Article
1970 Volume 41 Issue 4 Pages 302-303
Published: April 25, 1970
Released on J-STAGE: February 22, 2018
JOURNAL FREE ACCESSDownload PDF (324K) -
[in Japanese]Article type: Article
1970 Volume 41 Issue 4 Pages 303-304
Published: April 25, 1970
Released on J-STAGE: February 22, 2018
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[in Japanese]Article type: Article
1970 Volume 41 Issue 4 Pages 304-305
Published: April 25, 1970
Released on J-STAGE: February 22, 2018
JOURNAL FREE ACCESSDownload PDF (303K) -
[in Japanese]Article type: Article
1970 Volume 41 Issue 4 Pages 305-306
Published: April 25, 1970
Released on J-STAGE: February 22, 2018
JOURNAL FREE ACCESSDownload PDF (304K) -
[in Japanese]Article type: Article
1970 Volume 41 Issue 4 Pages 306-308
Published: April 25, 1970
Released on J-STAGE: February 22, 2018
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[in Japanese]Article type: Article
1970 Volume 41 Issue 4 Pages 308-
Published: April 25, 1970
Released on J-STAGE: February 22, 2018
JOURNAL FREE ACCESSDownload PDF (184K) -
[in Japanese]Article type: Article
1970 Volume 41 Issue 4 Pages 308-309
Published: April 25, 1970
Released on J-STAGE: February 22, 2018
JOURNAL FREE ACCESSDownload PDF (313K) -
[in Japanese]Article type: Article
1970 Volume 41 Issue 4 Pages 309-310
Published: April 25, 1970
Released on J-STAGE: February 22, 2018
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[in Japanese]Article type: Article
1970 Volume 41 Issue 4 Pages 311-
Published: April 25, 1970
Released on J-STAGE: February 22, 2018
JOURNAL FREE ACCESSDownload PDF (176K) -
[in Japanese], [in Japanese], [in Japanese]Article type: Article
1970 Volume 41 Issue 4 Pages 312-
Published: April 25, 1970
Released on J-STAGE: February 22, 2018
JOURNAL FREE ACCESSDownload PDF (171K) -
[in Japanese], [in Japanese], [in Japanese]Article type: Article
1970 Volume 41 Issue 4 Pages 312-
Published: April 25, 1970
Released on J-STAGE: February 22, 2018
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[in Japanese]Article type: Article
1970 Volume 41 Issue 4 Pages 312-313
Published: April 25, 1970
Released on J-STAGE: February 22, 2018
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[in Japanese], [in Japanese]Article type: Article
1970 Volume 41 Issue 4 Pages 313-
Published: April 25, 1970
Released on J-STAGE: February 22, 2018
JOURNAL FREE ACCESSDownload PDF (194K) -
[in Japanese], [in Japanese], [in Japanese]Article type: Article
1970 Volume 41 Issue 4 Pages 313-314
Published: April 25, 1970
Released on J-STAGE: February 22, 2018
JOURNAL FREE ACCESSDownload PDF (330K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese]Article type: Article
1970 Volume 41 Issue 4 Pages 314-
Published: April 25, 1970
Released on J-STAGE: February 22, 2018
JOURNAL FREE ACCESSDownload PDF (189K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese]Article type: Article
1970 Volume 41 Issue 4 Pages 314-
Published: April 25, 1970
Released on J-STAGE: February 22, 2018
JOURNAL FREE ACCESSDownload PDF (189K) -
[in Japanese], [in Japanese], [in Japanese]Article type: Article
1970 Volume 41 Issue 4 Pages 314-315
Published: April 25, 1970
Released on J-STAGE: February 22, 2018
JOURNAL FREE ACCESSDownload PDF (269K) -
[in Japanese], [in Japanese]Article type: Article
1970 Volume 41 Issue 4 Pages 315-
Published: April 25, 1970
Released on J-STAGE: February 22, 2018
JOURNAL FREE ACCESSDownload PDF (125K)
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