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Volume 63, Issue 3
Displaying 1-17 of 17 articles from this issue
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Yukio SHIBATAArticle type: Article
1989 Volume 63 Issue 3 Pages 111-122
Published: March 25, 1989
Released on J-STAGE: March 16, 2018
JOURNAL FREE ACCESSIt is well known that vitamin B_6 (B_6) is a preventive vitamin to dermatitis (Kuhn et al). The authors studied other effects of B_6. I. The relation between B_6 and diabetes. In 1952, Kotake and Inada reported that diabetogenic symptoms in B_6 deficient rats appeared and also histological changes of pancreas have been found. Our experiments show that pyridoxal kinase activity is decreased in B_6-deficient rat liver, and xanthurenic acid inhibit in vitro the liver pyridoxal kinase activity. Also, the ratio of PLP/PL in sera decreased in diabetic patients. II. The relation between B_6 and arteriosclerosis. The other important B_6-dependent-amino acid is methionine. Many authors have reported about the relation between B_6 and arteriosclerosis or hypercholes-terolemia in methionine metabolism. We have studied about methionine and also tryptophan metabolisms. When excessive methionine was administered to rats, B_6 deficient symptoms appeared in the rats (the urinary excretion of xanthurenic acid from tryptophan was increased). But B_6 deficiency did not appeared in the rats given taurine or taurine-containing food, for example, oyster. III. The relation between B_6 and kidney calculi formation (urolithiasis). In B_6 deficient rats, the following results were observed. 1) Kidney calculi were formed by the excessive calcium administration. 2) Calcium absorption increased in intestine membrane. 3) Calcium reabsorption decreased in tubular membrane. 4) The growth inhibitor of calcium oxalate monohydrate crystal was decreased.View full abstractDownload PDF (897K) -
Tadasu OGAWA, Yoshiro TOMONO, Nobumichi MORISHITA, Ryo SHISHIDOArticle type: Article
1989 Volume 63 Issue 3 Pages 123-131
Published: March 25, 1989
Released on J-STAGE: March 16, 2018
JOURNAL FREE ACCESSMecobalamin (CH_3-B_<12>), 500μg, was administered to 12 healthy adult volunteers by intravenous (IV) and intramuscular (IM)) injection by the cross-over method, and then the change in total B_<12> concentration in the serum was compared. The maximum serum B_<12> concentration (ΔC_<max>) and the area under the time curve (ΔAUC) of the serum total B_<12> concentration were both higher following IV injection than after IM injection: ca. 3.8-fold and 1.8-fold, respectively. These differences between the two administration routes were statistically significant. However, the saturated-bound rate, which reflects the amount of transcobalamin-II, was 90% or higher during the 1-12 hour period after administration by both routes. The subsequent pattern of decrease in this rate was similar for both routes. In addition, CH_3-B_<12> was administered to 6 healthy adult volunteers by IV injection of 500μg once a day for 10days. The minimum serum total B_<12> concentration (ΔC_<min>) increased gradually during the administration period and was about 1.7 times higher on 3 days after administration than on the first day. There-after, the concentration became constant. Moreover, the total B_<12> urinary excretion and the saturated-bound rate were increased during the 24-48 hour period after completion of the repeated administration. These findings indicate that, in repeated administration, B_<12> is accumulated in the liver and then gradually released into the blood.View full abstractDownload PDF (759K) -
Akira MURATA, Rumi BABA, Masayoshi MATSUOKA, Hiroshi OTSUKA, Tohoru TA ...Article type: Article
1989 Volume 63 Issue 3 Pages 133-139
Published: March 25, 1989
Released on J-STAGE: March 16, 2018
JOURNAL FREE ACCESSSix healthy males (20-23 years) ingested vitamin C preparations after breakfast according to a two-period crossover design in each trial. In Trial I, subjects ingested a vitamin C tablet (VC) or a multivitamin tablet (MV), each containing 250mg of vitamin C. No differences in either the plasma concentration-time profiles or the urinary excretion was observed between VC and MV. The peak pleasma vitamin C concentration occured at 3h, and approximately 34% of the dose was excreted into the urine in 24h. In Trial II, subjects ingested a vitamin C tablet or a sustained-release tablet (SR), each containing 500mg of vitamin C. Differences in the plasma concentration-time profiles and the urinary excretion were observed between VC and SR. With VC, the pask plasma vitamin C concentration occured at 3h, and approximately 37% of the does was excreted into the urine in 24h. With SR, the peak plasma vitamin C concentration occured from 6 to 9h, and 3 to 19% of the does was excreted into the urine in 24h, showing great intersubject variability.View full abstractDownload PDF (509K) -
Kumi NAKAO, Masayasu SUGIYAMA, Akikazu ANDO, Takachika SHOJI, Tsuyoshi ...Article type: Article
1989 Volume 63 Issue 3 Pages 141-145
Published: March 25, 1989
Released on J-STAGE: March 16, 2018
JOURNAL FREE ACCESSThe effects of Toc-suc or B_2 on the cytotoxicity of sodium chromate or UV light were examined by colony forming assay using Chinese hamster V-79 cells. Pretreatment with Toc-suc for 24h prior to exposure resulted in a decrease in the cytotoxicity of both sodium chromate and UV light. In contrast, similar pretreatment with B_2 did not influence the cytotoxicity of UV light. In the case of chromate, however, pretreatment with B_2 resulted in a decrease of cytotoxicity after exposure to the usual lethal does (15μM) of chromate, but did not affect the cytotoxicity at sublethal doses (5〜10μM) of this metal. Under chromate-exposure conditions, neither pretreatment with Toc-suc nor B_2 had any effect on cellular uptake of chromate. These results suggest that the induction of cytotoxicity by chromate and UV light may be associated with their generation of free radicals, and indicate that the effect of B_2 against cytoxicity may be due to a different mechanism than that for Toc-suc.View full abstractDownload PDF (509K) -
Kazumasa HIRAUCHI, Toshiyuki SAKANO, Shigeru NOTSUMOTO, Tadayoshi NAGA ...Article type: Article
1989 Volume 63 Issue 3 Pages 147-151
Published: March 25, 1989
Released on J-STAGE: March 16, 2018
JOURNAL FREE ACCESSVitamin K_1 (K_1) and vitamin K_2 (K_2) in foods were measured by a method based on high-performance liquid chromatography (HPLC) combined with coulometric reduction and fluorometric detection. The vitamins extracted from foods were purified with a Sep-Pak silica cartridge and/or a Sep-Pak silica cartridge followed by thin-layer chromatography, respectively, and then measured by using an HPLC system. More than 10ng/g or ml of K_1 was found in mackerel, abalone, top shell, horse muscles, chicken egg (yolk), formulated milk powder, cheese and butter, and more than 10ng/g or ml of K_2 was found in salmon, abalone, beef, pork, chicken, chicken egg (yolk), cheese and butter.View full abstractDownload PDF (401K) -
Article type: Bibliography
1989 Volume 63 Issue 3 Pages 153-155
Published: March 25, 1989
Released on J-STAGE: March 16, 2018
JOURNAL FREE ACCESSDownload PDF (215K) -
[in Japanese], [in Japanese]Article type: Article
1989 Volume 63 Issue 3 Pages 157-158
Published: March 25, 1989
Released on J-STAGE: March 16, 2018
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[in Japanese], [in Japanese]Article type: Article
1989 Volume 63 Issue 3 Pages 158-
Published: March 25, 1989
Released on J-STAGE: March 16, 2018
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[in Japanese], [in Japanese]Article type: Article
1989 Volume 63 Issue 3 Pages 158-159
Published: March 25, 1989
Released on J-STAGE: March 16, 2018
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]Article type: Article
1989 Volume 63 Issue 3 Pages 159-
Published: March 25, 1989
Released on J-STAGE: March 16, 2018
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[in Japanese]Article type: Article
1989 Volume 63 Issue 3 Pages 159-160
Published: March 25, 1989
Released on J-STAGE: March 16, 2018
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...Article type: Article
1989 Volume 63 Issue 3 Pages 160-161
Published: March 25, 1989
Released on J-STAGE: March 16, 2018
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[in Japanese]Article type: Article
1989 Volume 63 Issue 3 Pages 161-
Published: March 25, 1989
Released on J-STAGE: March 16, 2018
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[in Japanese], [in Japanese]Article type: Article
1989 Volume 63 Issue 3 Pages 161-162
Published: March 25, 1989
Released on J-STAGE: March 16, 2018
JOURNAL FREE ACCESSDownload PDF (284K) -
[in Japanese], [in Japanese], [in Japanese], A. Bille, E. Addo, E.E.K. ...Article type: Article
1989 Volume 63 Issue 3 Pages 162-
Published: March 25, 1989
Released on J-STAGE: March 16, 2018
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[in Japanese]Article type: Article
1989 Volume 63 Issue 3 Pages 163-164
Published: March 25, 1989
Released on J-STAGE: March 16, 2018
JOURNAL FREE ACCESSDownload PDF (297K) -
[in Japanese]Article type: Article
1989 Volume 63 Issue 3 Pages 164-165
Published: March 25, 1989
Released on J-STAGE: March 16, 2018
JOURNAL FREE ACCESSDownload PDF (289K)
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