VITAMINS

Online ISSN : 2424-080X
Print ISSN : 0006-386X

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Volume 86, Issue 2

Displaying 1-34 of 34 articles from this issue

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Development of a model of excess fat soluble vitamins : a tool to study malformation of hatchery-raised fishes

Yutaka Haga

Article type: Article
2012Volume 86Issue 2 Pages 55-62
Published: February 25, 2012
Released on J-STAGE: October 10, 2017

DOIhttps://doi.org/10.20632/vso.86.2_55

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It has been suggested that fat soluble vitamins are involved in the occurrence of both skeletal and pigment disorders of fish. Since it was noted that fat soluble vitamins affected both skeletal and pigment development, a model for excess fat soluble vitamins was developed. The critical stages were demonstrated for the skeletal and pigment disorders of metamorphosing flounder by using the model. This study also suggested that the retinoic acid receptor pathway is a major pathway to induce skeletal deformity and that the inhibition of vitamin D receptor, pitx-2 and sonic hedgehog expression is concomitant with the occurrence of skeletal deformity. A previous study reported that feeding a diet containing excessive amounts of vitamin D_3 elevated the possible risk of hypermelanosis. Because feeding a diet including 1,25 (OH) vitamin D_3 promoted the occurrence of hypermelanosis, dietary vitamin D_3 possibly was metabolized into 1,25 (OH) vitamin D_3 and then promoted the occurrence of hypermelanosis.

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Disease-targeted Enzymology on the Function and Structure of D-Amino Acid Metabolic System

Kiyoshi FUKUI

Article type: Article
2012Volume 86Issue 2 Pages 63-73
Published: February 25, 2012
Released on J-STAGE: October 10, 2017

DOIhttps://doi.org/10.20632/vso.86.2_63

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D-Amino acid oxidase (DAO) has been proposed to be involved in the decreased glutamatergic neurotransmission in schizophrenia and the modulation of its activity is expected to be therapeutic. Here we show the inhibitory effect of antipsychotic drugs, chlorpromazine and risperidone, on human DAO activity. In search of the pathophysiological role of DAO, we analyzed its distribution in brain. The immunoreactivity for DAO was detected in glial cells of rhombencephalon and in choroid plexus (CP) in the human brain. Furthermore, higher level of DAO expression was observed in schizophrenic CP epithelial cells. These results suggest that DAO expression level is altered in schizophrenia and the increase in DAO expression is involved in aberrant D-amino acid metabolism. In particular, gene expression of DAO in CP suggests that DAO may regulate D-amino acid concentration by modulating the cerebrospinal fluid, and may be regarded as a potential therapeutic target for schizophrenia.

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Structural and functional analyses of novel NAD(P)-dependent amino acid dehydrogenases from archaea

Kazunari Yoneda

Article type: Article
2012Volume 86Issue 2 Pages 74-83
Published: February 25, 2012
Released on J-STAGE: October 10, 2017

DOIhttps://doi.org/10.20632/vso.86.2_74

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NAD(P)-dependent amino acid dehydrogenases are oxidoreductase catalyzing the reversible oxidation of amino acids to their oxo or aldehyde analogs in the presence of NAD or NADP. The enzymes are useful for enzymatic analyses of amino acids, oxo acids and special enzymes, and for the enantiospecific synthesis of L-amino acids and their analogs. In contrast to abundant information available about glutamate, alanine, leucine and phenylalanine dehydrogenases, information about the structure and function of lysine, aspartate, threonine dehydrogenases has been rather limited so far. We have developed the functional and structural analyses of novel types of NAD(P)-dependent amino acid dehydrogenases from hyperthermophilic archaea. The enzymological and structural characteristics of the NAD(P)-dependent amino acid dehydrogenases from archaeal strains are here described.

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Up-regulation of glyceraldehyde-3-phosphate dehydrogenase gene expression by HIF-1 activity depending on Sp1 in hypoxic breast cancer cells

Yasuki Higashimura, Ryoichi Yamaji, Naoki Harada, Yoshihisa Nakano, Hi ...

Article type: Article
2012Volume 86Issue 2 Pages 84-86
Published: February 25, 2012
Released on J-STAGE: October 10, 2017

DOIhttps://doi.org/10.20632/vso.86.2_84

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Roles for zinc in the regulation of insulin and glucagon secretion

Tomoko Goto, Hitoshi Shirakawa, Michio Komai

Article type: Article
2012Volume 86Issue 2 Pages 87-89
Published: February 25, 2012
Released on J-STAGE: October 10, 2017

DOIhttps://doi.org/10.20632/vso.86.2_87

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Origin of corrinoid compounds B_<12> and its physiological function in eukaryotic and prokaryotic algae

[in Japanese]

Article type: Article
2012Volume 86Issue 2 Pages 90-93
Published: February 25, 2012
Released on J-STAGE: October 10, 2017

DOIhttps://doi.org/10.20632/vso.86.2_90

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[title in Japanese]

[in Japanese]

Article type: Article
2012Volume 86Issue 2 Pages 94-96
Published: February 25, 2012
Released on J-STAGE: October 10, 2017

DOIhttps://doi.org/10.20632/vso.86.2_94

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[title in Japanese]

[in Japanese]

Article type: Article
2012Volume 86Issue 2 Pages 96-98
Published: February 25, 2012
Released on J-STAGE: October 10, 2017

DOIhttps://doi.org/10.20632/vso.86.2_96

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[title in Japanese]

[in Japanese]

Article type: Article
2012Volume 86Issue 2 Pages 98-100
Published: February 25, 2012
Released on J-STAGE: October 10, 2017

DOIhttps://doi.org/10.20632/vso.86.2_98

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[title in Japanese]

[in Japanese]

Article type: Article
2012Volume 86Issue 2 Pages 100-103
Published: February 25, 2012
Released on J-STAGE: October 10, 2017

DOIhttps://doi.org/10.20632/vso.86.2_100

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[title in Japanese]

[in Japanese]

Article type: Article
2012Volume 86Issue 2 Pages 103-105
Published: February 25, 2012
Released on J-STAGE: October 10, 2017

DOIhttps://doi.org/10.20632/vso.86.2_103

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

Article type: Article
2012Volume 86Issue 2 Pages 106-
Published: February 25, 2012
Released on J-STAGE: October 10, 2017

DOIhttps://doi.org/10.20632/vso.86.2_106_1

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[title in Japanese]

[in Japanese]

Article type: Article
2012Volume 86Issue 2 Pages 106-107
Published: February 25, 2012
Released on J-STAGE: October 10, 2017

DOIhttps://doi.org/10.20632/vso.86.2_106_2

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[title in Japanese]

[in Japanese]

Article type: Article
2012Volume 86Issue 2 Pages 107-108
Published: February 25, 2012
Released on J-STAGE: October 10, 2017

DOIhttps://doi.org/10.20632/vso.86.2_107

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[title in Japanese]

[in Japanese]

Article type: Article
2012Volume 86Issue 2 Pages 108-109
Published: February 25, 2012
Released on J-STAGE: October 10, 2017

DOIhttps://doi.org/10.20632/vso.86.2_108

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[title in Japanese]

[in Japanese], [in Japanese], Salah M. El Sayed, Rabab M. Abou El-Magd ...

Article type: Article
2012Volume 86Issue 2 Pages 109-110
Published: February 25, 2012
Released on J-STAGE: October 10, 2017

DOIhttps://doi.org/10.20632/vso.86.2_109

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[title in Japanese]

[in Japanese]

Article type: Article
2012Volume 86Issue 2 Pages 110-112
Published: February 25, 2012
Released on J-STAGE: October 10, 2017

DOIhttps://doi.org/10.20632/vso.86.2_110

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[title in Japanese]

[in Japanese]

Article type: Article
2012Volume 86Issue 2 Pages 112-
Published: February 25, 2012
Released on J-STAGE: October 10, 2017

DOIhttps://doi.org/10.20632/vso.86.2_112_1

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[title in Japanese]

[in Japanese]

Article type: Article
2012Volume 86Issue 2 Pages 112-113
Published: February 25, 2012
Released on J-STAGE: October 10, 2017

DOIhttps://doi.org/10.20632/vso.86.2_112_2

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[title in Japanese]

[in Japanese]

Article type: Article
2012Volume 86Issue 2 Pages 113-114
Published: February 25, 2012
Released on J-STAGE: October 10, 2017

DOIhttps://doi.org/10.20632/vso.86.2_113

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese]

Article type: Article
2012Volume 86Issue 2 Pages 114-
Published: February 25, 2012
Released on J-STAGE: October 10, 2017

DOIhttps://doi.org/10.20632/vso.86.2_114_1

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese]

Article type: Article
2012Volume 86Issue 2 Pages 114-115
Published: February 25, 2012
Released on J-STAGE: October 10, 2017

DOIhttps://doi.org/10.20632/vso.86.2_114_2

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[title in Japanese]

[in Japanese], [in Japanese], Do Thi Viet Huong, [in Japanese], [in Ja ...

Article type: Article
2012Volume 86Issue 2 Pages 115-116
Published: February 25, 2012
Released on J-STAGE: October 10, 2017

DOIhttps://doi.org/10.20632/vso.86.2_115

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese]

Article type: Article
2012Volume 86Issue 2 Pages 116-
Published: February 25, 2012
Released on J-STAGE: October 10, 2017

DOIhttps://doi.org/10.20632/vso.86.2_116

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese]

Article type: Article
2012Volume 86Issue 2 Pages 117-118
Published: February 25, 2012
Released on J-STAGE: October 10, 2017

DOIhttps://doi.org/10.20632/vso.86.2_117

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[title in Japanese]

[in Japanese]

Article type: Article
2012Volume 86Issue 2 Pages 118-
Published: February 25, 2012
Released on J-STAGE: October 10, 2017

DOIhttps://doi.org/10.20632/vso.86.2_118_1

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese]

Article type: Article
2012Volume 86Issue 2 Pages 118-119
Published: February 25, 2012
Released on J-STAGE: October 10, 2017

DOIhttps://doi.org/10.20632/vso.86.2_118_2

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[title in Japanese]

Article type: Bibliography
2012Volume 86Issue 2 Pages 120-123
Published: February 25, 2012
Released on J-STAGE: October 10, 2017

DOIhttps://doi.org/10.20632/vso.86.2_120

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[title in Japanese]

Article type: Appendix
2012Volume 86Issue 2 Pages 124-
Published: February 25, 2012
Released on J-STAGE: October 10, 2017

DOIhttps://doi.org/10.20632/vso.86.2_124

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[title in Japanese]

[in Japanese]

Article type: Article
2012Volume 86Issue 2 Pages 125-
Published: February 25, 2012
Released on J-STAGE: October 10, 2017

DOIhttps://doi.org/10.20632/vso.86.2_125_1

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[title in Japanese]

[in Japanese]

Article type: Article
2012Volume 86Issue 2 Pages 125-126
Published: February 25, 2012
Released on J-STAGE: October 10, 2017

DOIhttps://doi.org/10.20632/vso.86.2_125_2

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[title in Japanese]

[in Japanese]

Article type: Article
2012Volume 86Issue 2 Pages 126-127
Published: February 25, 2012
Released on J-STAGE: October 10, 2017

DOIhttps://doi.org/10.20632/vso.86.2_126

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[title in Japanese]

[in Japanese]

Article type: Article
2012Volume 86Issue 2 Pages 127-
Published: February 25, 2012
Released on J-STAGE: October 10, 2017

DOIhttps://doi.org/10.20632/vso.86.2_127

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[title in Japanese]

[in Japanese]

Article type: Article
2012Volume 86Issue 2 Pages 128-
Published: February 25, 2012
Released on J-STAGE: October 10, 2017

DOIhttps://doi.org/10.20632/vso.86.2_128

JOURNAL FREE ACCESS

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