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Hisataka TAGUCHI, Yoshiki TANI
Article type: Article
1997 Volume 71 Issue 5-6 Pages
213-220
Published: June 25, 1997
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Biochemical production of vitamin K (K_2 and K_3) was studied using microorganisms screened from soil samples. Fermentative production of menaquinone-4 (MK-4, one of vitamin K_2) was established by isolation of MK-4-producing mutants from Flavobacterium sp. 238-7, excretion of MK-4 into the culture broth with a detergent, and optimization of the conditions for jar-fermentor cultivation. Menadione (MD)-producing process was basically the microbial conversion of 2-methylnaphthalene (2MN) to MD via 2-methyl-1-naphthol (2MNOH). Methylethylketone utilizing bacteria screened were the good convertors of 2MN to 2MNOH. Ethylxanthate or diethyldithiocarbamate was a specific inhibitor for 2-naphthoic acid (side-product) production.
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Yoshihiro SHIDOJI, Yasutoshi MUTO
Article type: Article
1997 Volume 71 Issue 5-6 Pages
221-234
Published: June 25, 1997
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We have found that synthetic geranylgeranoic acid (GGA), 4, 5-didehydro GGA and 2, 3-dihydro GGA all equally bind to cellular retinoic acid-binding protein. Furthermore GGA and 4, 5-didehydro GGA were demonstrated as potent ligands both for nuclear retionic acid receptor and retinoid X receptor so that we named these polyprenoic acids as "acyclic retinoids". Recently, phase II clinical trial clearly showed efficacy of acyclic retinoid (4, 5-didehydro GGA) to prevent second primary hepatoma after surgical resection of the original tumor or the percutaneous injection of ethanol. A molecular mechanism underlying hepatoma preventive action is discussed with a special reference to apoptosis from animal and cell biological experiments. We speculate that GGA may be an endogenous signaling molecule which is synthesized de novo from mevalonate pathway.
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Article type: Appendix
1997 Volume 71 Issue 5-6 Pages
235-238
Published: June 25, 1997
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Article type: Appendix
1997 Volume 71 Issue 5-6 Pages
238-
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[in Japanese]
Article type: Article
1997 Volume 71 Issue 5-6 Pages
239-
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[in Japanese]
Article type: Article
1997 Volume 71 Issue 5-6 Pages
239-241
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[in Japanese]
Article type: Article
1997 Volume 71 Issue 5-6 Pages
241-242
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[in Japanese]
Article type: Article
1997 Volume 71 Issue 5-6 Pages
242-243
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[in Japanese]
Article type: Article
1997 Volume 71 Issue 5-6 Pages
243-245
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[in Japanese]
Article type: Article
1997 Volume 71 Issue 5-6 Pages
245-246
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[in Japanese]
Article type: Article
1997 Volume 71 Issue 5-6 Pages
246-248
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[in Japanese]
Article type: Article
1997 Volume 71 Issue 5-6 Pages
248-
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], A.G. Galki ...
Article type: Article
1997 Volume 71 Issue 5-6 Pages
249-250
Published: June 25, 1997
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1997 Volume 71 Issue 5-6 Pages
250-251
Published: June 25, 1997
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[in Japanese]
Article type: Article
1997 Volume 71 Issue 5-6 Pages
251-252
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[in Japanese]
Article type: Article
1997 Volume 71 Issue 5-6 Pages
252-253
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1997 Volume 71 Issue 5-6 Pages
253-254
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1997 Volume 71 Issue 5-6 Pages
254-255
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[in Japanese]
Article type: Article
1997 Volume 71 Issue 5-6 Pages
255-256
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]
Article type: Article
1997 Volume 71 Issue 5-6 Pages
256-257
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[in Japanese]
Article type: Article
1997 Volume 71 Issue 5-6 Pages
257-258
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[in Japanese], [in Japanese]
Article type: Article
1997 Volume 71 Issue 5-6 Pages
259-260
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[in Japanese]
Article type: Article
1997 Volume 71 Issue 5-6 Pages
260-262
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[in Japanese], [in Japanese]
Article type: Article
1997 Volume 71 Issue 5-6 Pages
262-263
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[in Japanese], [in Japanese]
Article type: Article
1997 Volume 71 Issue 5-6 Pages
263-264
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[in Japanese]
Article type: Article
1997 Volume 71 Issue 5-6 Pages
264-266
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[in Japanese]
Article type: Article
1997 Volume 71 Issue 5-6 Pages
266-268
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Article type: Appendix
1997 Volume 71 Issue 5-6 Pages
269-271
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Article type: Appendix
1997 Volume 71 Issue 5-6 Pages
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Article type: Cover
1997 Volume 71 Issue 5-6 Pages
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