VITAMINS
Online ISSN : 2424-080X
Print ISSN : 0006-386X
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Volume 89, Issue 10
Displaying 1-7 of 7 articles from this issue
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  • Vitamin A homeostasis by hepatic stellate cells
    Yoshihiro Mezaki
    Article type: Article
    2015 Volume 89 Issue 10 Pages 471-478
    Published: October 25, 2015
    Released on J-STAGE: August 10, 2017
    DOIhttps://doi.org/10.20632/vso.89.10_471
    JOURNAL FREE ACCESS
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    Hepatic stellate cells (HSCs) store a large amount of vitamin A within their cytoplasm as lipid droplets. HSCs store vitamin A as a form of retinylester through an enzymatic activity of lecithin:retinol acyltransferase (LRAT). Vitamin A and their active metabolites (retinoids) exert most of their physiological activities by transcription factors, retinoic acid receotors (RARα, β and γ) and retinoid X receptors (RXRα, β and γ). Cellular retinol-binding protein I (CRBP I) is one of the well characterized RAR target genes containing retinoic acid-responsive element (RARE). The mRNA levels of RARα, β and γ were decreased during rat HSC activation in vitro. Protein levels of RARα and β were increased during HSC activation. An RARE-containing luciferase assay indicated that HSCs became responsive to retinoids only after activation in vitro. CRBP I gene expression was up-regulated during HSC activation. CRBP I-bound retinol could be a good substrate of LRAT than retinol alone. Therefore, upregulation of RARα gene expression at the post-transcriptional level and subsequent upregulation of CRBP I gene expression at the transcriptional level make a feedback loop toward the recovery of vitamin A-containing lipid droplets within the activated hepatic stellate cells.
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  • The association of MTHFR C677T gene polymorphism and incidence of colorectal cancer : meta-analysis on case-control study and/or cohort study
    Minako Kobayashi, Tomomi Masuda, Nobuya Shiozawa, Asuka Uchida, Masako ...
    Article type: Article
    2015 Volume 89 Issue 10 Pages 479-491
    Published: October 25, 2015
    Released on J-STAGE: August 10, 2017
    DOIhttps://doi.org/10.20632/vso.89.10_479
    JOURNAL FREE ACCESS
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    Methylenetetrahydrofolate reductase (MTHFR) is an essential enzyme involved in folate metabolism. MTHFR gene polymorphism (C677T), comprised of wild (CC), hetero (CT), and homo (TT) genotypes, have been implicated in several types of cancer. However, the association of MTHFR C677T polymorphism and carcinogenesis is not clear at present. This study was aimed to investigate meta-analytically which organ is the most susceptible to carcinogenesis caused by the genetic polymorphism and to clarify the association of the polymorphism and the incidence of cancer in the determined organ. Case-control and/or cohort studies describing the relation of MTHFR C677T polymorphism with cancer incidence from the PubMed database up to September, 2014 were searched to identify potentially eligible articles. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to estimate the strength of the associations. The search yielded 565 reports and among them, 61 reports on colorectal cancer met the inclusion criteria. When only the MTHFR C677T polymorphic CC type and CT type were compared for rectal cancer incidence (CT vs. CC: OR=1.10 [95% CI, 1.00-1.21], P=0.04), a significant difference was recognized. In addition, only for colorectal cancer incidence (TT vs. CC: OR=0.83 [95% CI, 0.74-0.93], P=0.001), a significant difference was recognized when comparison between the CC type and TT type was made.
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  • Human hepatic metabolism of the anti-osteoporosis drug eldecalcitol involves sterol C4-methyl oxidase
    Kaori Yasuda, Yuasa Iwanaga, Kazuaki Ogawa, Hiroki Mano, Sera Ueno, Sh ...
    Article type: Article
    2015 Volume 89 Issue 10 Pages 492-494
    Published: October 25, 2015
    Released on J-STAGE: August 10, 2017
    DOIhttps://doi.org/10.20632/vso.89.10_492
    JOURNAL FREE ACCESS
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  • Recombinant expression, molecular characterization and crystal structure of antitumor enzyme, L-lysine α-oxidase from Trichoderma viride
    Marie Amano, Haruka Mizuguchi, Tadahisa Sano, Hiroki Kondo, Kengo Shin ...
    Article type: Article
    2015 Volume 89 Issue 10 Pages 495-498
    Published: October 25, 2015
    Released on J-STAGE: August 10, 2017
    DOIhttps://doi.org/10.20632/vso.89.10_495
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese]
    Article type: Article
    2015 Volume 89 Issue 10 Pages 499-500
    Published: October 25, 2015
    Released on J-STAGE: August 10, 2017
    DOIhttps://doi.org/10.20632/vso.89.10_499
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    Article type: Article
    2015 Volume 89 Issue 10 Pages 500-501
    Published: October 25, 2015
    Released on J-STAGE: August 10, 2017
    DOIhttps://doi.org/10.20632/vso.89.10_500
    JOURNAL FREE ACCESS
    Download PDF (250K)
  • [title in Japanese]
    Article type: Bibliography
    2015 Volume 89 Issue 10 Pages 502-506
    Published: October 25, 2015
    Released on J-STAGE: August 10, 2017
    DOIhttps://doi.org/10.20632/vso.89.10_502
    JOURNAL FREE ACCESS
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