All issues
Volume 68, Issue 12
Displaying 1-32 of 32 articles from this issue
- |<
- <
- 1
- >
- >|
-
Wataru SAKAMOTOArticle type: Article
1994 Volume 68 Issue 12 Pages 699-710
Published: December 25, 1994
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSTo clarify the role of vitamin E in the modulation of macrophages, we investigated its effect on O_2^- and PGE_2 production in macrophages. Macrophases isolated from vitamin E-treated rats, and containing an extremely high level of α-tocophrol, showed lower O_2^- and PGE_2 production following stimulation with PMA or calcium ionophore A23187 compared to those of control macrophages. We also investigated the mechanism by which vitamin E inhibits both O_2^- and PGE_2 production in macrophages, by measuring the activities of protein kinase C and phospholipase A_2 in intact macrophages and cell-free homogenate system. Vitamin E did not directly inhibit phospholipase A_2 activity but inhibited phospholipase A_2 activation through phosphorylation and translocation of the enzyme itself in the intracellular signal transduction. From these results, it was concluded that the action of vitamin E was due to indirect inhibition of NADPH oxidase and phospholipase A_2 activities through the signal transduction system such as protein kinase C and intracellular Ca^<2+>.View full abstractDownload PDF (1434K) -
Kunihiko FUJIWARA, Takahiro ASAO, Makoto IKEDA, Kensuke KISARA, Shiger ...Article type: Article
1994 Volume 68 Issue 12 Pages 711-719
Published: December 25, 1994
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSAlthough the methods of high-performance liquid chromatography with electrochemical detection for the determination of vitamin K (K_s) in human plasma had already reported, they have some problems including the effect of dissolved oxygen in mobile phase on background current, losing sensitivity of electrode due to adsorption of reducted compounds on to the surface of the electrode, and single determination for phylloquinone (K_1). For the resolution of these problems, we tried to use a platinum black column for the reduction of K_s instead of electrochemical reduction, and an amperometric electrochemical detector in the oxidation mode. Therefore, we developed a sensitive method for the simultaneous determination of K_1 and menaquinons (MK-4, MK-7) in human plasma. The detection limits in the present method were 0.05 ng/ml of K_1, MK-4 and 0.1 ng/ml of MK-7.View full abstractDownload PDF (740K) -
Tadasu FURUSHO, Sigeaki KATO, Kanjyu OHSAWA, Shoichi MASUSHIGEArticle type: Article
1994 Volume 68 Issue 12 Pages 721-727
Published: December 25, 1994
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSAll-trans-retinyl β-glucuronide (ROG) which is water soluble was chemically synthesized and studied its biological activity. Weanling wistar male rats were fed on a vitamin A deficient diet for 30 days, and divided into 3 groups. Each rat in the 1st group was orally given with 5.2 μmol of ROG on the last day, animals in the 2nd group were given with vitamin A acetate (A-ace), and the 3rd group was remained as a vitamin A deficient control. At 48 hours after administration, retinol contents in liver and serum of rats were determined. Serum retinol levels in rats given with ROG significantly increased, but not in liver. However, serum retinol levels of ROG group were lower than those of A-ace group. Then, the effect of ROG on growth of the young rats was examined as compared with A-ace, and vitamin A deficiency. Rats in each group were orally given with 21 nmol/day of ROG or A-ace for 28 days. ROG supported the growth of young rat, although its ability was inferior to A-ace. And ROG was also effective to recover the body weight loss of rats with vitamin A deficiency. These results show that animals could convert ROG into retinol in vivo, and ROG has activities as the vitamin A.View full abstractDownload PDF (608K) -
[in Japanese]Article type: Article
1994 Volume 68 Issue 12 Pages 729-732
Published: December 25, 1994
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (472K) -
[in Japanese], [in Japanese]Article type: Article
1994 Volume 68 Issue 12 Pages 733-738
Published: December 25, 1994
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (634K) -
Article type: Appendix
1994 Volume 68 Issue 12 Pages 739-741
Published: December 25, 1994
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (259K) -
[in Japanese], [in Japanese], [in Japanese]Article type: Article
1994 Volume 68 Issue 12 Pages 743-
Published: December 25, 1994
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (156K) -
[in Japanese], [in Japanese], [in Japanese]Article type: Article
1994 Volume 68 Issue 12 Pages 743-744
Published: December 25, 1994
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (289K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...Article type: Article
1994 Volume 68 Issue 12 Pages 744-745
Published: December 25, 1994
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (314K) -
[in Japanese]Article type: Article
1994 Volume 68 Issue 12 Pages 745-
Published: December 25, 1994
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (182K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], P. ChambonArticle type: Article
1994 Volume 68 Issue 12 Pages 745-746
Published: December 25, 1994
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (312K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...Article type: Article
1994 Volume 68 Issue 12 Pages 746-
Published: December 25, 1994
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (184K) -
[in Japanese]Article type: Article
1994 Volume 68 Issue 12 Pages 746-747
Published: December 25, 1994
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (253K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...Article type: Article
1994 Volume 68 Issue 12 Pages 749-750
Published: December 25, 1994
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (311K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...Article type: Article
1994 Volume 68 Issue 12 Pages 750-
Published: December 25, 1994
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (195K) -
[in Japanese]Article type: Article
1994 Volume 68 Issue 12 Pages 751-752
Published: December 25, 1994
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (313K) -
[in Japanese]Article type: Article
1994 Volume 68 Issue 12 Pages 752-
Published: December 25, 1994
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (192K) -
[in Japanese], [in Japanese]Article type: Article
1994 Volume 68 Issue 12 Pages 752-753
Published: December 25, 1994
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (317K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...Article type: Article
1994 Volume 68 Issue 12 Pages 753-754
Published: December 25, 1994
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (312K) -
[in Japanese]Article type: Article
1994 Volume 68 Issue 12 Pages 754-
Published: December 25, 1994
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (187K) -
[in Japanese]Article type: Article
1994 Volume 68 Issue 12 Pages 754-755
Published: December 25, 1994
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (307K) -
D. Casirola, G. Gastaldi, G. Ferrari, G. Rindi, [in Japanese], [in Jap ...Article type: Article
1994 Volume 68 Issue 12 Pages 755-756
Published: December 25, 1994
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (297K) -
[in Japanese], [in Japanese]Article type: Article
1994 Volume 68 Issue 12 Pages 756-
Published: December 25, 1994
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (173K) -
[in Japanese]Article type: Article
1994 Volume 68 Issue 12 Pages 756-758
Published: December 25, 1994
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (425K) -
[in Japanese]Article type: Article
1994 Volume 68 Issue 12 Pages 758-759
Published: December 25, 1994
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (312K) -
[in Japanese]Article type: Article
1994 Volume 68 Issue 12 Pages 759-760
Published: December 25, 1994
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (320K) -
[in Japanese], [in Japanese]Article type: Article
1994 Volume 68 Issue 12 Pages 760-761
Published: December 25, 1994
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (285K) -
[in Japanese], [in Japanese], [in Japanese]Article type: Article
1994 Volume 68 Issue 12 Pages 761-
Published: December 25, 1994
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (143K) -
[in Japanese]Article type: Article
1994 Volume 68 Issue 12 Pages 763-764
Published: December 25, 1994
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (255K) -
[in Japanese]Article type: Article
1994 Volume 68 Issue 12 Pages 764-766
Published: December 25, 1994
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (434K) -
[in Japanese]Article type: Article
1994 Volume 68 Issue 12 Pages 766-768
Published: December 25, 1994
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (401K) -
[in Japanese]Article type: Article
1994 Volume 68 Issue 12 Pages 768-770
Published: December 25, 1994
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (343K)
- |<
- <
- 1
- >
- >|