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Volume 78, Issue 2
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Maya KAMAO, Toshio OKANOArticle type: Article
2004 Volume 78 Issue 2 Pages 79-86
Published: February 25, 2004
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSIt is well established that the active form of vitamin D_3, 1α, 25-dihydroxyvitamin D_3[1a, 25(OH)_2D_3], is metabolized through C-24 and C-23/26 oxidation pathways. Recently, we identified novel 1α, 25(OH)_2D_3 metabolite, 3-epi-1α, 25(OH)_2D_3, in which C-3 hydroxyl group is epimerized from the β to the α position. It was also demonstrated that the natural vitamin D3 metabolites, 25-hydiroxyvitamin D_3 [25 (OH)D_3], 24R, 25-dihydroxyvitamin D_3 [24,25(OH)_2D_3] and a synthetic analog, 22-oxacalcitriol [22-oxa-1α, 25(OH)_2D_3, OCT] are metabolized via the C-3 epimerization pathway. 3-epi-1α, 25(OH)_2D_3, is further metabolized to C-24 hydroxide, 3-epi-1α, 24, 25(OH)_3, D_3. In addition, 3-epi-25 (OH)D_3, is metabolized to both C-1α hydroxide, 3-epi-1α, 25(OH)_2D_3, and C-24 hydroxide, 3-epi-24, 25(OH)_2D_3, like-wise 25(OH)D_3. The other novel metabolites of OCT were identified as two kinds of C-25 dehydrates, 25-dehydroxy-25-ene-22-oxa-1α-hydroxyvitamin D_3[25-ene-22-oxa-1α(OH)D_3] and 25-dehydroxy-24-ene-22-oxa-1α-hydroxyvitamin D_3 [24-ene-22-oxa-1α(OH)D_3]. The differences existed in the production rate of C-3 epimers and C-25 dehydrates with different cell types. The biological activity ofthese metabolites is lower than that of their substrate compounds.View full abstractDownload PDF (753K) -
Takanori YOKOTAArticle type: Article
2004 Volume 78 Issue 2 Pages 87-92
Published: February 25, 2004
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSI found the new disease 'familial ataxia with idiopathic vitamin E deficiency (AVED)' without fat malabsorption. I identified the causative gene : α-tocopherol transfer protein (αTTP). By impairing αTTP function in the liver, α-tocopherol cannot be transferred to VLDL, resulting in low concentration of serum vitamin E. l establish the disease entity and made clear the clinical picture of posterior column ataxia and retinitis pigmentosa. Furthermore, by investigating αTTP knockout mouse, I clarify the mechanism of vitamin E deficiency and neuronal degeneration. In this disease, almost symptoms can be prevented to progress by vitamin E supplementation.View full abstractDownload PDF (696K) -
[in Japanese], [in Japanese]Article type: Article
2004 Volume 78 Issue 2 Pages 93-94
Published: February 25, 2004
Released on J-STAGE: October 10, 2017
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[in Japanese], [in Japanese]Article type: Article
2004 Volume 78 Issue 2 Pages 95-
Published: February 25, 2004
Released on J-STAGE: October 10, 2017
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[in Japanese], [in Japanese]Article type: Article
2004 Volume 78 Issue 2 Pages 95-98
Published: February 25, 2004
Released on J-STAGE: October 10, 2017
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[in Japanese], [in Japanese]Article type: Article
2004 Volume 78 Issue 2 Pages 98-100
Published: February 25, 2004
Released on J-STAGE: October 10, 2017
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[in Japanese]Article type: Article
2004 Volume 78 Issue 2 Pages 101-102
Published: February 25, 2004
Released on J-STAGE: October 10, 2017
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[in Japanese]Article type: Article
2004 Volume 78 Issue 2 Pages 102-104
Published: February 25, 2004
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (442K) -
[in Japanese]Article type: Article
2004 Volume 78 Issue 2 Pages 104-107
Published: February 25, 2004
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (493K) -
[in Japanese]Article type: Article
2004 Volume 78 Issue 2 Pages 107-108
Published: February 25, 2004
Released on J-STAGE: October 10, 2017
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[in Japanese]Article type: Article
2004 Volume 78 Issue 2 Pages 109-110
Published: February 25, 2004
Released on J-STAGE: October 10, 2017
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[in Japanese]Article type: Article
2004 Volume 78 Issue 2 Pages 110-111
Published: February 25, 2004
Released on J-STAGE: October 10, 2017
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Article type: Bibliography
2004 Volume 78 Issue 2 Pages 113-116
Published: February 25, 2004
Released on J-STAGE: October 10, 2017
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...Article type: Article
2004 Volume 78 Issue 2 Pages 117-118
Published: February 25, 2004
Released on J-STAGE: October 10, 2017
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...Article type: Article
2004 Volume 78 Issue 2 Pages 118-119
Published: February 25, 2004
Released on J-STAGE: October 10, 2017
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[in Japanese], [in Japanese]Article type: Article
2004 Volume 78 Issue 2 Pages 119-120
Published: February 25, 2004
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (298K) -
[in Japanese]Article type: Article
2004 Volume 78 Issue 2 Pages 120-
Published: February 25, 2004
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (172K) -
[in Japanese]Article type: Article
2004 Volume 78 Issue 2 Pages 120-
Published: February 25, 2004
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (172K) -
[in Japanese]Article type: Article
2004 Volume 78 Issue 2 Pages 120-121
Published: February 25, 2004
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (286K) -
[in Japanese], [in Japanese]Article type: Article
2004 Volume 78 Issue 2 Pages 121-
Published: February 25, 2004
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (169K)
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