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Yasuo TOHIRA, Yoshikazu HINOHARA, Machiko OGAWA, Hiroshi KAMIYAMA, Hid ...
Article type: Article
1978 Volume 52 Issue 8 Pages
341-352
Published: August 25, 1978
Released on J-STAGE: March 07, 2018
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The absorption, distribution, excretion and metabolism of 2-^3H-1α-OH-D_3 (4.2 Ci/mmol) were studied in rat after oral or intravenous dosing. (1) Peak blood level of administered radioactivity was observed at 10 hours after oral administration with apparent half life of 2.4 days whereas that was 2.3 days after intravenous administration. (2) Administered radioactivity was distributed relatively high in the liver, while any other specific distribution or accumulation was not observed in the another tissues. (3) Together with the results of excretion studies, it revealed that major part (91%) of radioactivity administered via intravenous route recycled enterohepatically finally excreted to feces. (4) Appleciable amount of ^3H-1α, 25-(OH)_2-D_3 could be detected in all tissues and body fluids examined after both oral and intravenous dosing using Sephadex LH-20 column chromatography, suggesting that this compound was the main metabolite in rat.
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Yasuo TOHIRA, Yoshikazu HINOHARA, Hiroshi KAMIYAMA, Machiko OGAWA, Hid ...
Article type: Article
1978 Volume 52 Issue 8 Pages
353-361
Published: August 25, 1978
Released on J-STAGE: March 07, 2018
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The absorption, distribution, excretion and metabolism of 2-^3H-1α-OH-D_3 (4.2 Ci/mmol) were studied in vitamin D deficient rats in comparison with the normal rats after oral or intravenous dosing. (1) Maximum blood level of administered radioactivity was observed at 8 hours after oral administration with apparent half life of 3.8 days. This blood level was higher than that in normal rat. (2) As in the normal rat, administered radioactivity was distributed relatively high in the liver, while any other specific distribution or accumulation was not observed in the another tissues, which was consistent to the finding in the normal rat. The tissue levels of the radioactivity were higher than these in the normal rat. (3) Urinary excretion of administered radioactivity was significantly higher, fecal and biliary excretion was significantly lower than that in the normal rat after intravenous dosing. (4) Relative percentage of ^3H-1α, 25-(OH)_2-D_3 content to ^3H-1α-OH-D_3 content in tissues and blood was higher than that in the normal one. Above results suggest that in the vitamin D deficient state, the tissue accumulation of 1α-OH-D_3 was significantly augmented than in the normal rat, thus resulting increased bioavailability of its active metabolite, 1α, 25-(OH)_2-D_3.
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[in Japanese]
Article type: Article
1978 Volume 52 Issue 8 Pages
362-
Published: August 25, 1978
Released on J-STAGE: March 07, 2018
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Hiroshi TAGUCHI, Hiroshi TAKAMIZAWA, Masako MUTO, Yoshihide SHIMABAYAS ...
Article type: Article
1978 Volume 52 Issue 8 Pages
363-370
Published: August 25, 1978
Released on J-STAGE: March 07, 2018
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Niacin compounds were extracted from hog liver and kidney with ethanol at the final concentration of 70%. The extracted compounds were separated into each compound by paper chromatography using various solvent systems. Each compound was identified by comparing its Rf value with that of authentic compound and various specific reactions. The isolated compounds were determined by microbiological assay with Lactobacillus arabinosus 17-5. The results obtained in liver and kidney indicated a similar pattern. Detected compounds were as follows in the order of the amount ; NiANH_2,NAD, NADP, NiA, NMN, d-NAD and NaMN. But QA and MNA were not detectable. NiANH_2 content was extremely high at the level of 80% of the total niacin compounds detected. NiANH_2 is thought to be a reserved precursor compound for the NAD biosynthesis. Total amount of niacin compounds per 100g of each organ was calculated as 58μmol in liver and 37μmol in kidney.
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]
Article type: Article
1978 Volume 52 Issue 8 Pages
371-
Published: August 25, 1978
Released on J-STAGE: March 07, 2018
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
1978 Volume 52 Issue 8 Pages
371-
Published: August 25, 1978
Released on J-STAGE: March 07, 2018
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[in Japanese]
Article type: Article
1978 Volume 52 Issue 8 Pages
371-372
Published: August 25, 1978
Released on J-STAGE: March 07, 2018
JOURNAL
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
1978 Volume 52 Issue 8 Pages
372-
Published: August 25, 1978
Released on J-STAGE: March 07, 2018
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Naomi Trostler, David Sklan
Article type: Article
1978 Volume 52 Issue 8 Pages
372-
Published: August 25, 1978
Released on J-STAGE: March 07, 2018
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
1978 Volume 52 Issue 8 Pages
372-373
Published: August 25, 1978
Released on J-STAGE: March 07, 2018
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]
Article type: Article
1978 Volume 52 Issue 8 Pages
373-
Published: August 25, 1978
Released on J-STAGE: March 07, 2018
JOURNAL
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1978 Volume 52 Issue 8 Pages
373-
Published: August 25, 1978
Released on J-STAGE: March 07, 2018
JOURNAL
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]
Article type: Article
1978 Volume 52 Issue 8 Pages
373-374
Published: August 25, 1978
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[in Japanese], [in Japanese]
Article type: Article
1978 Volume 52 Issue 8 Pages
374-
Published: August 25, 1978
Released on J-STAGE: March 07, 2018
JOURNAL
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]
Article type: Article
1978 Volume 52 Issue 8 Pages
374-
Published: August 25, 1978
Released on J-STAGE: March 07, 2018
JOURNAL
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]
Article type: Article
1978 Volume 52 Issue 8 Pages
374-
Published: August 25, 1978
Released on J-STAGE: March 07, 2018
JOURNAL
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
1978 Volume 52 Issue 8 Pages
375-
Published: August 25, 1978
Released on J-STAGE: March 07, 2018
JOURNAL
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1978 Volume 52 Issue 8 Pages
375-
Published: August 25, 1978
Released on J-STAGE: March 07, 2018
JOURNAL
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]
Article type: Article
1978 Volume 52 Issue 8 Pages
375-
Published: August 25, 1978
Released on J-STAGE: March 07, 2018
JOURNAL
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]
Article type: Article
1978 Volume 52 Issue 8 Pages
376-
Published: August 25, 1978
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1978 Volume 52 Issue 8 Pages
377-378
Published: August 25, 1978
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
1978 Volume 52 Issue 8 Pages
378-
Published: August 25, 1978
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]
Article type: Article
1978 Volume 52 Issue 8 Pages
378-379
Published: August 25, 1978
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1978 Volume 52 Issue 8 Pages
379-380
Published: August 25, 1978
Released on J-STAGE: March 07, 2018
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[in Japanese], [in Japanese]
Article type: Article
1978 Volume 52 Issue 8 Pages
380-
Published: August 25, 1978
Released on J-STAGE: March 07, 2018
JOURNAL
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]
Article type: Article
1978 Volume 52 Issue 8 Pages
380-381
Published: August 25, 1978
Released on J-STAGE: March 07, 2018
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[in Japanese]
Article type: Article
1978 Volume 52 Issue 8 Pages
382-
Published: August 25, 1978
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
1978 Volume 52 Issue 8 Pages
383-
Published: August 25, 1978
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]
Article type: Article
1978 Volume 52 Issue 8 Pages
384-
Published: August 25, 1978
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[in Japanese]
Article type: Article
1978 Volume 52 Issue 8 Pages
385-
Published: August 25, 1978
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[in Japanese], [in Japanese]
Article type: Article
1978 Volume 52 Issue 8 Pages
385-386
Published: August 25, 1978
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
1978 Volume 52 Issue 8 Pages
386-
Published: August 25, 1978
Released on J-STAGE: March 07, 2018
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]
Article type: Article
1978 Volume 52 Issue 8 Pages
386-387
Published: August 25, 1978
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]
Article type: Article
1978 Volume 52 Issue 8 Pages
387-
Published: August 25, 1978
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]
Article type: Article
1978 Volume 52 Issue 8 Pages
387-388
Published: August 25, 1978
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[in Japanese], [in Japanese]
Article type: Article
1978 Volume 52 Issue 8 Pages
388-
Published: August 25, 1978
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[in Japanese], [in Japanese]
Article type: Article
1978 Volume 52 Issue 8 Pages
389-
Published: August 25, 1978
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
1978 Volume 52 Issue 8 Pages
389-390
Published: August 25, 1978
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
1978 Volume 52 Issue 8 Pages
390-391
Published: August 25, 1978
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]
Article type: Article
1978 Volume 52 Issue 8 Pages
391-
Published: August 25, 1978
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JOURNAL
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]
Article type: Article
1978 Volume 52 Issue 8 Pages
391-392
Published: August 25, 1978
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[in Japanese], [in Japanese]
Article type: Article
1978 Volume 52 Issue 8 Pages
392-
Published: August 25, 1978
Released on J-STAGE: March 07, 2018
JOURNAL
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
1978 Volume 52 Issue 8 Pages
393-394
Published: August 25, 1978
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]
Article type: Article
1978 Volume 52 Issue 8 Pages
394-
Published: August 25, 1978
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JOURNAL
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
1978 Volume 52 Issue 8 Pages
394-
Published: August 25, 1978
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[in Japanese]
Article type: Article
1978 Volume 52 Issue 8 Pages
395-
Published: August 25, 1978
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[in Japanese]
Article type: Article
1978 Volume 52 Issue 8 Pages
395-396
Published: August 25, 1978
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[in Japanese]
Article type: Article
1978 Volume 52 Issue 8 Pages
396-398
Published: August 25, 1978
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