VITAMINS
Online ISSN : 2424-080X
Print ISSN : 0006-386X
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Volume 44, Issue 2
Displaying 1-15 of 15 articles from this issue
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  • Absorption of Vitamin B_<12> in the Cat and its Relation to B_<12> Binders in Gastric Juice
    Kazunori MOROKUMA
    Article type: Article
    1971 Volume 44 Issue 2 Pages 69-75
    Published: August 25, 1971
    Released on J-STAGE: February 27, 2018
    DOIhttps://doi.org/10.20632/vso.44.2_69
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    In view of the recent demonstration of the lack of intrinsic factor activity in dog gastric juice, both B_<12> absorption and the role of gastfic juice were investigated on cats, among carnivorous species. About fifty cats were used in the study, and absorption of ^<57>Co-B_<12> placed in a cleaned and ligated ileal segment was measured. It was found that 0.005-0.03μg of B_<12> was poorly absorbed while absorption of doses above 0.2μg was good. Coadministration of neutralized gastric juice invariably reduced absorption, while dog or human pancreatic juice collected from the duodenum under the influence of Pancreozymin and Secretin increased absorption of small doses of B_<12>. Similar enhancement of absorption of small doses of B_<12> was achieved by rat stomach mucosa extract. The presence of EDTA in the loop, however, did not interfere with the effect of rat intrinsic factor; different absorption mechanism of small amounts of B_<12> in cats was suggested in comparison with species known to have intrinsic factor. These findings in the cat including the B_<12> binders in gastric juice demonstrated by column chromatography and gel-filtration are very similar to those recently reported by Kitazaki in the dog.
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  • Speed of Vitamin B_<12> Turnover and its Relation to the Intestine in the Rat
    Tohru KOMINATO
    Article type: Article
    1971 Volume 44 Issue 2 Pages 76-83
    Published: August 25, 1971
    Released on J-STAGE: February 27, 2018
    DOIhttps://doi.org/10.20632/vso.44.2_76
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    [in Japanese]
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  • Relation between Pyruvic Acid Contents in Organs and Thiamine Deficient Cardiac Lesions
    Seizo YAMASHITA
    Article type: Article
    1971 Volume 44 Issue 2 Pages 84-89
    Published: August 25, 1971
    Released on J-STAGE: February 27, 2018
    DOIhttps://doi.org/10.20632/vso.44.2_84
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    To study the correlation between pyruvic acid contents and thiamine deficient cardiac lesions, the pyruvic acid contents in blood and organs of thiamine deficient, control pair fed and normal rats were determined. It was found that pyruvic acid accumulation in blood and especially in heart muscle, is the strong factor of thiamine deficient cardiac lesions.
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  • Reduction and Degradation of Modified Thiamine Compounds by Microorganisms (III) CONVERSION OF DISULFIDE-FORM DERIVATIVES OF THIAMINE TO THIAMINE BY ESCHERICHIA COLI (2)
    Masahiro NISHII, Takeo KISHI, Masaomi KONDO
    Article type: Article
    1971 Volume 44 Issue 2 Pages 90-95
    Published: August 25, 1971
    Released on J-STAGE: February 27, 2018
    DOIhttps://doi.org/10.20632/vso.44.2_90
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    TPD, when incubated with Escherichia coli, was reduced to thiamine and practically all the reduced thiamine was found in the medium, not in cells. There is no difference between reduction of TPD by spheroplasts and that by intact cells. TPD was shown to be reduced equally by ghosts or cytoplasm. Uptake of TPD by E. coli was greater than that of thiamine. TPD uptaken into cells was detected as phosphorylated thamine and free thiamine but not as TPD. Free thiamine was detected more highly in the case of TPD uptake. TPD uptake was not dependent on energy source and not inhibited by pyrithiamine and deoxythiamine in contrast with thiamine uptake. TPD uptake ceased at about 30 min, but occured again when the cells were suspended into fresh medium containing TPD. Release of intracellular thiamine compounds into medium was not observed. On the other hand, TPD uptake was similar to the mode of thiamine uptake in the low concentration of TPD.
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  • Relationship between Blood Pantothenic Acid Content of Females and Aging
    Kozo ISHIGURO
    Article type: Article
    1971 Volume 44 Issue 2 Pages 96-99
    Published: August 25, 1971
    Released on J-STAGE: February 27, 2018
    DOIhttps://doi.org/10.20632/vso.44.2_96
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    Measurement of specific gravity, haemoglobin content, haematcrit value and pantothenic acid content on blood samples of rural female inhabitants over 40 years of age was carried out. The level of bound pantothenic acid in blood declined with age and its decreasing tendency was remarkable between subjects in the age classes of 40-49 years and 50-59 years, although free pantothenic acid contents were found to be almost constant in each age group.
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  • Studies on vitamin B_6 Derivatives (XV) ON FOUR TYPES OF VTAMIN B_6 IN BLOOD AFTER ADMINISTRAITION OF PYRIDOXAL-DEHYDROHOMOCYSTEINE THIOLACTONE AND OTHER B_6 DERIVATIVES
    Tamotsu DANNO, Yukishige HASHIGUCHI, Akiko NAKAMA, Kenji MASUKAWA, Ken ...
    Article type: Article
    1971 Volume 44 Issue 2 Pages 100-104
    Published: August 25, 1971
    Released on J-STAGE: February 27, 2018
    DOIhttps://doi.org/10.20632/vso.44.2_100
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    The level of the four types (pyridoxal, pyridoxamine and their phosphates) of vitamin B_6 in blood of rabbit had been investigated at different time after an oral administration of vitaimin B_6 derivatives, including N-(4-pyridoxyl) dehydrohomocysteine thiolactone (PAL-DHT). After an oral administration of PAL-DHT to rabbit, total vitamin B_6 level in blood was markedly greater than that of administration of other vitamin B_6 derivatives, and reached a maximum 4 hours later, and about 80% of total vitamin B_6 was recovered as pyridoxamine phosphate (PAM-P). When PAL-DHT was injected in the ligated intestine in situ, a large quantity of PAM-P in the mesentric vein blood was recovered. These findings suggested that PAL-DHT might be readily metabolized to PAM and phosphorylized to PAM-P in the transporting process through the intestinal wall. And the differential patterns were observed in the increased level of vitamin B_6 in blood after administration of PAL plus DL-Homocysteine mixture and PAL-HCySH. Also the half-life of total vitamin B_6 in blood after oral administration of vitamin B_6 derivatives were calculated respectively.
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  • Ultramicroscopic Study on the Kidney of Vitamin B_6-Deficient Rats : A MECHANISM OF OXALATE STONE FORMATION
    Etsuji TAKASAKI
    Article type: Article
    1971 Volume 44 Issue 2 Pages 105-109
    Published: August 25, 1971
    Released on J-STAGE: February 27, 2018
    DOIhttps://doi.org/10.20632/vso.44.2_105
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    The kidneys of rats treated for 30 to 50 days with the experimental Vitamin B_6 deficient diet with normal or low magnesium content were examined by electron microscopy. Slight increased number of vacuoles and lysosomal bodies were observed in the proximal convoluted tubuli of vitamin B_6-deficient rats, and the cell debris was prominent in tubular lumen. On the other hand, in the proximal convoluted tubuli of the rats lacking vitamin B_6 and magnesium, the abundant large lysosomal bodies appeared in cytoplasms and the tubular lumen contained the numerous cell debris which had the similar appearance of cellular organelles seen in the proximal tubuli. These observations suggest that the primary step of urinary stone formation is the apatite which is formed in the proximal convoluted tubuli by magnesium depletion and in secondary step the oxalate which is excreted increasingly by vitamin B_6-deficiency precipitates on this apatite.
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  • A New Fluorometric Method of Retinoic Acid (Preliminary Report)
    Yoshio ITO, Tetsuo OHKUMA, Toshihiro IIO, Toshikazu TABATA
    Article type: Article
    1971 Volume 44 Issue 2 Pages 110-114
    Published: August 25, 1971
    Released on J-STAGE: February 27, 2018
    DOIhttps://doi.org/10.20632/vso.44.2_110
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    Treatment of retinoic acid in cyclohexane with 74%-sulfuric acid, followed by dilution with water, gave a fluorescent product which was extracted with cyclohexane, showing maxima at 333mμ in the excitation spectrum and at 425mμ in the emission spectrum. The fluorescent product was shown to be stable to heat, though very labile to light. The fluorescence intensity was completely proportional to the concentration of retinoic acid (0.2-100.0μg). Therefore, this method will be available for the determination of retinoic acid.
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    Article type: Article
    1971 Volume 44 Issue 2 Pages 115-
    Published: August 25, 1971
    Released on J-STAGE: February 27, 2018
    DOIhttps://doi.org/10.20632/vso.44.2_115_1
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  • [title in Japanese]
    [in Japanese], [in Japanese]
    Article type: Article
    1971 Volume 44 Issue 2 Pages 115-116
    Published: August 25, 1971
    Released on J-STAGE: February 27, 2018
    DOIhttps://doi.org/10.20632/vso.44.2_115_2
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    Article type: Article
    1971 Volume 44 Issue 2 Pages 116-
    Published: August 25, 1971
    Released on J-STAGE: February 27, 2018
    DOIhttps://doi.org/10.20632/vso.44.2_116
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese]
    Article type: Article
    1971 Volume 44 Issue 2 Pages 117-
    Published: August 25, 1971
    Released on J-STAGE: February 27, 2018
    DOIhttps://doi.org/10.20632/vso.44.2_117_1
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese]
    Article type: Article
    1971 Volume 44 Issue 2 Pages 118-
    Published: August 25, 1971
    Released on J-STAGE: February 27, 2018
    DOIhttps://doi.org/10.20632/vso.44.2_118_1
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    Article type: Article
    1971 Volume 44 Issue 2 Pages 118-119
    Published: August 25, 1971
    Released on J-STAGE: February 27, 2018
    DOIhttps://doi.org/10.20632/vso.44.2_118_2
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  • [title in Japanese]
    [in Japanese]
    Article type: Article
    1971 Volume 44 Issue 2 Pages 119-120
    Published: August 25, 1971
    Released on J-STAGE: February 27, 2018
    DOIhttps://doi.org/10.20632/vso.44.2_119
    JOURNAL FREE ACCESS
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