All issues
Volume 83, Issue 2
Displaying 1-8 of 8 articles from this issue
- |<
- <
- 1
- >
- >|
-
Akira Murata, Hidetoshi Tashiro, Kyoko Kawabata, Kazunari Horie, Mikak ...Article type: Article
2009 Volume 83 Issue 2 Pages 49-52
Published: February 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSThe bactericidal activity of L-ascorbic acid (AsA) is well known. To elucidate the correlation of structure of AsA with the bactericidal activity, 13 derivatives substituted at C2, C3, C5 and C6 of AsA were synthesized and examined for bactericidal activity using eight bacterial species. C2- and C2,6-substituted derivatives, in general, had lower activity than AsA. C6- and C5,6-substituted derivatives had the same activity as AsA. C3- and C2,3-substituted derivatives had no activity. The findings indicate that the bactericidal activity of AsA is based on the enediol system and OH-group at C3 in the enediol system is necessary for the activity. Another purpose of this study is to find out AsA derivatives with higher activity than AsA. 2-O-octanoyl-AsA and 2,6-di-O-octanoyl-AsA exhibited higher bactericidal activity against Lactobacillus casei and Staphylococcus aureusView full abstractDownload PDF (489K) -
Akira Murata, Hidetoshi Tashiro, Naoji Murayama, Akio Ogisu, Yoshiko O ...Article type: Article
2009 Volume 83 Issue 2 Pages 53-57
Published: February 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSWe synthesized eight fluorine-containing derivatives of asocorbic acid (AsA) and examined for phage-inactivating effect using nine phages. 2,6-Bis-O-perfluorooctanoyl-AsA (8) and 2,6-bis-O-(7,H-dodecafluoroheptanoyl)-AsA (12) exhibited 3〜8 times greater effect than AsA. The reaction mechanism of the phage-inactivating effect of 8 and 12 was investigated. Bubbling oxygen through the reaction mixture enhanced the inactivation. Bubbling nitrogen through the reaction mixture inhibited the inactivation. Addition to the reaction mixture of H_2O_2 and transition metal ions enhanced the inactivation. Addition of reducing agents, chelating agents and radical scavengers inhibited the inactivation. The findings indicate that the phage-inactivating effect is associated with free radical mechanism due to reactive oxygen species. The increase in the inactivating effect can be attributed to the introduction at C(2) and C(6) of substituents containing highly electronegative fluorine.View full abstractDownload PDF (640K) -
Satoshi InoueArticle type: Article
2009 Volume 83 Issue 2 Pages 59-64
Published: February 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSVitamin K is a critical nutrient in the bone metabolism. We have demonstrated that SXR, a nuclear receptor steroid and xenobiotic receptor, expressed in bone cells could be activated by vitamin K_2 as a ligand. vitamin K_2 regulates the expression of various bone-related genes in osteoblastic cells. We have identified novel SXR targets that were up-regulated by vitamin K_2 in human osteoblastic cells. Tsukushi, a small leucine-rich repeat proteoglycan, has been shown to contribute to vitamin K-dependent collagen accumulation. Thus, we have discovered an alternative pathway of vitamin K action in the bone via transcriptional regulation utilizing nuclear receptor SXR.View full abstractDownload PDF (775K) -
Kazuo SuekiArticle type: Article
2009 Volume 83 Issue 2 Pages 65-68
Published: February 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (605K) -
Mayu Shiori, Masaru SonodaArticle type: Article
2009 Volume 83 Issue 2 Pages 69-70
Published: February 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (303K) -
Masaaki InabaArticle type: Article
2009 Volume 83 Issue 2 Pages 71-73
Published: February 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESS -
Hiroshi Taguchi, Hiroshi TamaiArticle type: Article
2009 Volume 83 Issue 2 Pages 74-
Published: February 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (390K) -
Article type: Bibliography
2009 Volume 83 Issue 2 Pages 75-79
Published: February 25, 2009
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (628K)
- |<
- <
- 1
- >
- >|