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Volume 78, Issue 12
Displaying 1-10 of 10 articles from this issue
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Takayuki TAKAHASHI, Tadashi OKAMOTO, Takeo KISHIArticle type: Article
2004 Volume 78 Issue 12 Pages 587-598
Published: December 25, 2004
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSCoenzyme Q (CoQ, Ubiquinone) is well-known to act as an essential carrier for the electron transfer from flavin proteins to the bc1 complex and concomitant trans-membrane transport of protons in the mitochondrial respiratory chain. However, COQ is found in all intracellular organelles and it appears to be provided by the endoplasmic reticulum-Golgi system as well as mitochondria. These observations suggest that intracellular CoQ may also have important physiological roles besides the mitochondrial respiratory chain. A greater part of CoQ widely distributed in intracellular organelles and serum is present as ubiquinol, the reduced form, and is suggested to act as an endogenous antioxidant. In addition, it is also suggested that COQ may be involved in activation of some uncoupling proteins, mitochondrial permeability transition, apoptosis and so on. This paper focuses on newly revealed physiological roles of CoQ in various biological systems.View full abstractDownload PDF (1057K) -
Tadashi OGAWAArticle type: Article
2004 Volume 78 Issue 12 Pages 599-608
Published: December 25, 2004
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSFood allergy is becoming a serious nutritional problem among young generation in developed countries including Japan. This review summerizes the relationship between the Japanese dietary life and the incidence of food allergy, the food constituents eliciting food allergy, especially allergenic proteins found in plant food-stuffs as pathogenesis-related proteins, the development of hypoallergenic foods using soybean as a Japanese traditional food-stuff, and a countermeasure for preventing the risk of food allergy from daily diet and constructing an anti-allergy dietary life. Recent topics on a food labeling law issued against the allergenic foods are also added. Key words: food allergy, allergen, pathogenesis-related protein, hypoallergenic food, soybeanView full abstractDownload PDF (913K) -
Mari MAEDA-YAMAMOTOArticle type: Article
2004 Volume 78 Issue 12 Pages 609-619
Published: December 25, 2004
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSAnti-allergic and anti-cancer metastatic components in tealeaves were screened using animal cultured cells. We found that epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3"Me) or epigallocatechin3-O-(4-O-methyl) gallate (EGCG4"Me) inhibited mast cell activation (histamine release, leukotrienes release, and degranulation) through suppression of intracellular protein kinasese, so we are now developing anti-allergic foods using tea cultivar 'Benifuki' which is rich in EGCG3"Me. Furthermore, EGCG and methylated EGCGs suppressed the gelatin degradation mediated by matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9), which were secreted into the conditioned medium of human metastatic cell line HT1080. This suppression of MMPs activities was correlated with that EGCG derivatives inhibited the expression of MMP-2 and MMP-9 mRNA dosedependently. Especially EGCG suppressed MMPs mRNA expression and further MMP-9 promoter activity significantly. Furthermore, EGCG strongly inhibited the activation of extracellular signalregulated kinase (ERK1/2) which is group of MAPkinase (MAPK) was necessary for MMP-9 upregulation. These findings supposed that methylated EGCGs in tealeaves are useful for development of anti-allergic or anti-metastatic functional foods.View full abstractDownload PDF (924K) -
[in Japanese]Article type: Article
2004 Volume 78 Issue 12 Pages 621-623
Published: December 25, 2004
Released on J-STAGE: October 10, 2017
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[in Japanese]Article type: Article
2004 Volume 78 Issue 12 Pages 624-625
Published: December 25, 2004
Released on J-STAGE: October 10, 2017
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[in Japanese]Article type: Article
2004 Volume 78 Issue 12 Pages 625-627
Published: December 25, 2004
Released on J-STAGE: October 10, 2017
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[in Japanese], [in Japanese]Article type: Article
2004 Volume 78 Issue 12 Pages 629-630
Published: December 25, 2004
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (254K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...Article type: Article
2004 Volume 78 Issue 12 Pages 630-
Published: December 25, 2004
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (157K) -
[in Japanese]Article type: Article
2004 Volume 78 Issue 12 Pages 630-631
Published: December 25, 2004
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (270K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...Article type: Article
2004 Volume 78 Issue 12 Pages 631-632
Published: December 25, 2004
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (257K)
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