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Volume 61, Issue 5-6
Displaying 1-19 of 19 articles from this issue
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Isuke IMADA, Kayoko OKAMOTOArticle type: Article
1987 Volume 61 Issue 5-6 Pages 175-191
Published: June 15, 1987
Released on J-STAGE: March 16, 2018
JOURNAL FREE ACCESSOxidation of succinate and NADH in UQ-depleted mitochondrial preparations was restored by some low molecular weight quinones including QSA-10 (idebenone). QSA-10 inhibited lipid peroxidation dependent on NADH (NADPH)/ADP-Fe^lt:3+> in canine brain mitochondria and protected the resulting inactivation of NADH-Cyt c reductase activity. QSA-10 did not virtually affect the activities of succinate oxidase in canine and rat brain mitochondria and suppressed the oxygen consumption in NADH oxidation, which might be related to the inhibition of lipid peroxidation. These results, supported by those from ex vivo tests, suggest that QSA-10 acts as an electron carrier in respiratory chains and functions as an antioxidant against membrane damage caused by lipid peroxidation in brain mitochondria.View full abstractDownload PDF (1645K) -
Yoshiaki KAYATA, Kenichi FUKAO, Koji YOSHIGA, Kazuaki TAKADA, Kyuichir ...Article type: Article
1987 Volume 61 Issue 5-6 Pages 193-197
Published: June 15, 1987
Released on J-STAGE: March 16, 2018
JOURNAL FREE ACCESSTo find applicability of assay procedures of lathosterol 5-desaturase in rat liver microsomes to measurement of the enzyme activity in mouse skin, the enzyme reaction was examined using [^3H] labeled lathosterol. Specific activity of the enzyme thus measured was identical with that measured by the spectro-photometric method. Thus the spectrophotometric method can be used for the assay of lathosterol 5-desaturase in the skin microsomes. On the other hand, spectrophotometric method may also be used for the assay of provitamin D_3 7-reductase in the liver microsomes, where the method monitors the decrease of provitamin D_3. However, this method may not be applicable to the assay of the enzyme in the skin because of high contents of provitamin D_3 and low specific activity of the enzyme in the skin microsomes.View full abstractDownload PDF (418K) -
Akira MURATA, Hidetoshi SOEJIMA, Naoji MURAYAMA, Yoshiko OTA, Fumio KA ...Article type: Article
1987 Volume 61 Issue 5-6 Pages 199-204
Published: June 15, 1987
Released on J-STAGE: March 16, 2018
JOURNAL FREE ACCESSThe phage-inactivating activity of L-ascorbic acid (AsA) is well known. To examine the structure-activity relationship of AsA, 13 derivatives substituted at C2, C3, C5 or C6 of AsA were synthesized and tested for phage-inactivating activity against 9 phages. C2- and C2,6-substituted derivatives, in general, had the same activity as ASA or lower activity than AsA. C6- and C5,6-substituted ones had the same activity as AsA. C3- and C2,3-substituted ones had no activity. The results obtained show that the phage-inactivating activity of ASA is due to the enediol system and the hydroxyl group at C3 in the enediol system is necessary for the activity. Another purpose of this study is to find ASA derivatives with higher activity than AsA. 2-O-octanoyl-AsA exhibited about 3 times higher activity on phage MS2 and 2,6-di-O-benzoyl-AsA did about 10 times higher activity on phage T5.View full abstractDownload PDF (532K) -
Article type: Appendix
1987 Volume 61 Issue 5-6 Pages 205-208
Published: June 15, 1987
Released on J-STAGE: March 16, 2018
JOURNAL FREE ACCESSDownload PDF (342K) -
[in Japanese]Article type: Article
1987 Volume 61 Issue 5-6 Pages 209-210
Published: June 15, 1987
Released on J-STAGE: March 16, 2018
JOURNAL FREE ACCESSDownload PDF (305K) -
[in Japanese]Article type: Article
1987 Volume 61 Issue 5-6 Pages 210-
Published: June 15, 1987
Released on J-STAGE: March 16, 2018
JOURNAL FREE ACCESSDownload PDF (193K) -
[in Japanese]Article type: Article
1987 Volume 61 Issue 5-6 Pages 210-212
Published: June 15, 1987
Released on J-STAGE: March 16, 2018
JOURNAL FREE ACCESSDownload PDF (475K) -
[in Japanese]Article type: Article
1987 Volume 61 Issue 5-6 Pages 212-213
Published: June 15, 1987
Released on J-STAGE: March 16, 2018
JOURNAL FREE ACCESSDownload PDF (330K) -
[in Japanese], [in Japanese]Article type: Article
1987 Volume 61 Issue 5-6 Pages 214-215
Published: June 15, 1987
Released on J-STAGE: March 16, 2018
JOURNAL FREE ACCESSDownload PDF (338K) -
[in Japanese]Article type: Article
1987 Volume 61 Issue 5-6 Pages 215-216
Published: June 15, 1987
Released on J-STAGE: March 16, 2018
JOURNAL FREE ACCESSDownload PDF (308K) -
[in Japanese]Article type: Article
1987 Volume 61 Issue 5-6 Pages 216-
Published: June 15, 1987
Released on J-STAGE: March 16, 2018
JOURNAL FREE ACCESSDownload PDF (167K) -
[in Japanese], [in Japanese], [in Japanese]Article type: Article
1987 Volume 61 Issue 5-6 Pages 217-
Published: June 15, 1987
Released on J-STAGE: March 16, 2018
JOURNAL FREE ACCESSDownload PDF (166K) -
[in Japanese], [in Japanese]Article type: Article
1987 Volume 61 Issue 5-6 Pages 217-218
Published: June 15, 1987
Released on J-STAGE: March 16, 2018
JOURNAL FREE ACCESSDownload PDF (275K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...Article type: Article
1987 Volume 61 Issue 5-6 Pages 218-
Published: June 15, 1987
Released on J-STAGE: March 16, 2018
JOURNAL FREE ACCESSDownload PDF (157K) -
[in Japanese]Article type: Article
1987 Volume 61 Issue 5-6 Pages 219-220
Published: June 15, 1987
Released on J-STAGE: March 16, 2018
JOURNAL FREE ACCESSDownload PDF (318K) -
[in Japanese]Article type: Article
1987 Volume 61 Issue 5-6 Pages 220-222
Published: June 15, 1987
Released on J-STAGE: March 16, 2018
JOURNAL FREE ACCESSDownload PDF (435K) -
[in Japanese]Article type: Article
1987 Volume 61 Issue 5-6 Pages 222-223
Published: June 15, 1987
Released on J-STAGE: March 16, 2018
JOURNAL FREE ACCESSDownload PDF (317K) -
[in Japanese]Article type: Article
1987 Volume 61 Issue 5-6 Pages 223-225
Published: June 15, 1987
Released on J-STAGE: March 16, 2018
JOURNAL FREE ACCESSDownload PDF (427K) -
[in Japanese], [in Japanese]Article type: Article
1987 Volume 61 Issue 5-6 Pages 225-226
Published: June 15, 1987
Released on J-STAGE: March 16, 2018
JOURNAL FREE ACCESSDownload PDF (254K)
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