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Volume 67, Issue 2
Displaying 1-23 of 23 articles from this issue
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Tatsuya MATSURA, Takashi KAWASAKIArticle type: Article
1993 Volume 67 Issue 2 Pages 41-50
Published: February 25, 1993
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSIn vivo and in vitro experimental data from our laboratory have provided evidence showing that coenzyme Q homolog (CoQ_n), especially its reduced form (CoQ_nH_2), acts as an antioxidant which protects cells from oxidative damage. The mechanism of antioxidant function of CoQ_nH_2, especially in relation to that of α-tocopherol (α-Toc), has been also studied with isolated hepatocytes exposed to a water-soluble radical initiator, 2, 2'-azobis (2-amidinopropane) dihydrochloride (AAPH). Evidence obtained supports the following views. 1. CoQ_nH_2, but not oxidized CoQ_n, has a potent antioxidant activity by scavenging lipid-peroxyl radicals in a variety of in vivo and ex vivo experiments. 2. The antioxidant activity of endogenous CoQ_9H_2 is different from that of endogenous CoQ_<10>H_2 : the former act as a better antioxidant than the latter in isolated hepatocytes exposed to AAPH. 3. The antioxidant function of endogenous CoQ_nH_2 is independent of that of endogenous α-Toc and both act as strong antioxidants against cellular damage induced by AAPH.View full abstractDownload PDF (906K) -
Satoshi WATANABE, Saju KAWAUCHIArticle type: Article
1993 Volume 67 Issue 2 Pages 51-55
Published: February 25, 1993
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSin the in vitro peroxidation of linoleic acid micelles induced with 2, 2-azobis-(2-amidinopropane) dihydrochloride (AAPH), a water-soluble radical initiator, or with 2, 2-azobis (2, 4-dimethylvaleronitrile) (AMVN), a lipid-soluble radical initiactor, in the presence of sodium dodecyl sulfate the inhibitory effect of riboflavin was investigated by measurement of the dissolved oxygen content in the reaction mixture by use of an oxygen electrode. In the case of each radical initiator, the decrease in the dissolved oxygen content was quantitatively inhibited by riboflavin, and the time of riboflavin disappearance from the reaction mixture coincided with the coculusion of the inhibition period of the oxygen absorption.View full abstractDownload PDF (523K) -
Masako SATO, Katumitu HAYAKAWA, Kohsuke NISINO, Yosinori ITOKAWAArticle type: Article
1993 Volume 67 Issue 2 Pages 57-65
Published: February 25, 1993
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSThe binding of thiamin to two kinds of melanins, one separated from carp eye tissues and the other synthesized from tyrosine, was measured in the presence of various drugs : chlorpromazine, kanamycin, chloroquin, streptomycin, paraquat, hidralazine, quinidine, nortriptyline, amitriptyline and imipramine. All of these drugs strongly inhibited the binding of thiamin to both melanins at high concentrations over 1 mM of the drugs, and the inhibition degree varied with the kind of drugs. Some of the drugs also induced the release of thiamin bound to melanin of eye in vivo. The binding curves were constructed for thiamin and chlorpromazine by both of the melanin sample. Thiamin showed regular Langmuir type binding, while chlorpromazine showed strong cooperative binding. Though the intrinsic binding constant was much higher for thiamin than for chlorpromazine, more chlorpromazine than thiamin bound to both melanins at high concentrations as a result of the cooperative binding. We concluded that competitive binding of drugs induced the inhibition of thiamin binding to melanin, as well as the release of thiamin bound to melanin in vivo.View full abstractDownload PDF (898K) -
Hiroshi TAGUCHI, Yoshihiro YAMADA, Hiroshi NISHITANI, Katsuzumi OKUMUR ...Article type: Article
1993 Volume 67 Issue 2 Pages 67-72
Published: February 25, 1993
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSThe effects of nicotinic acid-related compounds on the nicotinamidase activity in cultured cells of tobacco (Nicotiana tabacum XD-6) were investigated. The specific activity of the enzyme in the cells cultured in the presence of each compound at 1 mM was varied considerably. Isonicotinamide, picolinamide, 2-aminobenzamide, and benzamide enhanced the specific activity 2.5〜5.5 times. On the contrary, 3-aminobenzamide, 3-cyanopyridine, and benzoic acid (0.1 mM) supressed the specific activity to 2/3〜1/4. All these compounds were inhibitory to the growth of tobacco cells (23〜51% inhibition). Benzamide, 3-aminobenzamide, 2-aminobenzamide, and 3-cyanopyridine inhibited the enyzme reaction strongly (49〜81% inhibition) when each compound was present at 1 mM in the reaction mixture. It was also found that benzamide acted as a stabilizer for the enzyme.View full abstractDownload PDF (550K) -
Article type: Appendix
1993 Volume 67 Issue 2 Pages 73-76
Published: February 25, 1993
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (326K) -
[in Japanese]Article type: Article
1993 Volume 67 Issue 2 Pages 77-78
Published: February 25, 1993
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (305K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese]Article type: Article
1993 Volume 67 Issue 2 Pages 78-79
Published: February 25, 1993
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (306K) -
[in Japanese], [in Japanese]Article type: Article
1993 Volume 67 Issue 2 Pages 79-
Published: February 25, 1993
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (168K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...Article type: Article
1993 Volume 67 Issue 2 Pages 80-
Published: February 25, 1993
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (178K) -
[in Japanese]Article type: Article
1993 Volume 67 Issue 2 Pages 80-81
Published: February 25, 1993
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (292K) -
[in Japanese], [in Japanese]Article type: Article
1993 Volume 67 Issue 2 Pages 82-
Published: February 25, 1993
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (172K) -
[in Japanese], [in Japanese]Article type: Article
1993 Volume 67 Issue 2 Pages 83-
Published: February 25, 1993
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (173K) -
[in Japanese], [in Japanese]Article type: Article
1993 Volume 67 Issue 2 Pages 83-84
Published: February 25, 1993
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (313K) -
[in Japanese]Article type: Article
1993 Volume 67 Issue 2 Pages 84-85
Published: February 25, 1993
Released on J-STAGE: March 30, 2018
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[in Japanese], [in Japanese], [in Japanese]Article type: Article
1993 Volume 67 Issue 2 Pages 85-86
Published: February 25, 1993
Released on J-STAGE: March 30, 2018
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[in Japanese]Article type: Article
1993 Volume 67 Issue 2 Pages 86-
Published: February 25, 1993
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (171K) -
[in Japanese], [in Japanese]Article type: Article
1993 Volume 67 Issue 2 Pages 87-
Published: February 25, 1993
Released on J-STAGE: March 30, 2018
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]Article type: Article
1993 Volume 67 Issue 2 Pages 87-88
Published: February 25, 1993
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (239K) -
[in Japanese], [in Japanese]Article type: Article
1993 Volume 67 Issue 2 Pages 89-90
Published: February 25, 1993
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (196K) -
[in Japanese]Article type: Article
1993 Volume 67 Issue 2 Pages 91-92
Published: February 25, 1993
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (310K) -
[in Japanese]Article type: Article
1993 Volume 67 Issue 2 Pages 92-93
Published: February 25, 1993
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (307K) -
[in Japanese]Article type: Article
1993 Volume 67 Issue 2 Pages 93-95
Published: February 25, 1993
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (418K) -
[in Japanese]Article type: Article
1993 Volume 67 Issue 2 Pages 95-96
Published: February 25, 1993
Released on J-STAGE: March 30, 2018
JOURNAL OPEN ACCESSDownload PDF (246K)
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