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Volume 73, Issue 11
Displaying 1-18 of 18 articles from this issue
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Toshio OKANO, Kimie NAKAGAWA, Keiichi Ozono, Noboru KUBODERA, Koichi M ...Article type: Article
1999 Volume 73 Issue 11 Pages 635-647
Published: November 25, 1999
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSRecently, growing interests have been focused on the development of hybrid-analogues with modifications of the A-ring and the side chain of 1α,25-dihydroxyvitamin D_3[1α,25(OH)_2D_3]. An exocyclic methylene group at C-10, a hydroxy group at C-1 and a hydroxy group at C-3 play a crucial role in the expression of biological activities. However, relationship between the functional groups and activities has not been fully understood. We have synthesized and evaluated biological activities of several singly dehydoxylated A-ring analogues of 19-nor-1α,25(OH)_2D_3 and 19-nor-22-oxa-1α,25(OH)_2D_3. All of them have an extremely low binding affinity for vitamin D receptor (VDR). Some of them lack the lrt-hydroxy group that is considered to be essential for VDR-mediated gene expres sion, have greater or equivalent potencies to 1α,25(OH)_2D_3 for inducing differentiation and cell cycle G_0-G_1 arrest of HL-60 cells as well as for the transactivation of target genes including a rat 25(OH)D_3 24-hydroxylase gene promoter and a human osteocalcin gene promoter in transfected mammalian cells. The assessment of a ligand/VDR/Retinoid X receptor (RXR) complex formation using a two hybrid luciferase assay revealed that the liganded VDR has high potency to form a heterodimer, but this could not explain the high biological potency of the 19-nor analogues. Other reason(s) including an interaction with transcriptional cofactors should be considered to explain the mechanism of action of 19-nor analogues.View full abstractDownload PDF (1175K) -
Kaname KODAKA, Takashi UJIIE, Fumiko HIRAHARAArticle type: Article
1999 Volume 73 Issue 11 Pages 649-657
Published: November 25, 1999
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSAn outline of the analytical methods used for various kinds of vitamins in general foods is intro duced. These methods were adopted in the 5th revised Standard Tables of Food Composition in Japan and in the Food Labeling Law in 1996. Attention for particular information is pointed out and described in correct analysis of each vitamin. In this article, shematic flow diagrams for the analytical methods of vitamin A, α-carotene,β-carotene, D_2, D_3, E, K_1, K_2, B_1, B_2, C, niacin, B_6, B_<12>, folic acid, and pantothenic acid are shown.View full abstractDownload PDF (823K) -
[in Japanese]Article type: Article
1999 Volume 73 Issue 11 Pages 659-664
Published: November 25, 1999
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (682K) -
[in Japanese]Article type: Article
1999 Volume 73 Issue 11 Pages 665-669
Published: November 25, 1999
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (597K) -
[in Japanese]Article type: Article
1999 Volume 73 Issue 11 Pages 671-677
Published: November 25, 1999
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (1015K) -
[in Japanese], [in Japanese]Article type: Article
1999 Volume 73 Issue 11 Pages 679-683
Published: November 25, 1999
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (594K) -
[in Japanese]Article type: Article
1999 Volume 73 Issue 11 Pages 685-689
Published: November 25, 1999
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (528K) -
[in Japanese]Article type: Article
1999 Volume 73 Issue 11 Pages 691-697
Published: November 25, 1999
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (734K) -
[in Japanese]Article type: Article
1999 Volume 73 Issue 11 Pages 699-700
Published: November 25, 1999
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (309K) -
[in Japanese]Article type: Article
1999 Volume 73 Issue 11 Pages 700-701
Published: November 25, 1999
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (310K) -
[in Japanese], [in Japanese]Article type: Article
1999 Volume 73 Issue 11 Pages 701-702
Published: November 25, 1999
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (298K) -
[in Japanese], [in Japanese], [in Japanese]Article type: Article
1999 Volume 73 Issue 11 Pages 703-
Published: November 25, 1999
Released on J-STAGE: December 26, 2017
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[in Japanese], [in Japanese], [in Japanese]Article type: Article
1999 Volume 73 Issue 11 Pages 703-704
Published: November 25, 1999
Released on J-STAGE: December 26, 2017
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]Article type: Article
1999 Volume 73 Issue 11 Pages 704-705
Published: November 25, 1999
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (326K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...Article type: Article
1999 Volume 73 Issue 11 Pages 705-
Published: November 25, 1999
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (187K) -
[in Japanese]Article type: Article
1999 Volume 73 Issue 11 Pages 706-
Published: November 25, 1999
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (187K) -
[in Japanese]Article type: Article
1999 Volume 73 Issue 11 Pages 706-707
Published: November 25, 1999
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (300K) -
[in Japanese]Article type: Article
1999 Volume 73 Issue 11 Pages 707-
Published: November 25, 1999
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (165K)
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