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Kunio OKUDA
Article type: Article
1999 Volume 73 Issue 5-6 Pages
297-302
Published: May 25, 1999
Released on J-STAGE: December 26, 2017
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This review describes the historic background of the discovery of vitamin B_<12> that began with the clinical study made by Minot and Murphy who successfully treated patients with pernicious anemia by feeding large quantities of beef liver. It was followed by a series of human experiments conducted by Castle who elaborately demonstrated that hemopoiesis required an exogenous food (extrinsic) factor as well as an endogenous factor that resided in the gastric juice (intrinsic factor). Led by this hypothesis, the extrinsic factor was subsequently identified in the liver as vitamin B_<12> and the intrinsic factor as a glycoprotein produced by the parietal cells of the stomach. Based on these studies and discoveries, pernicious anemia is now an established autoimmune disease with an epitope residing in the membrane of the parietal cell.
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Makiko KAWAGUCHI, Mikako KISHIMOTO, Ayumi MURAKAMI, Toshiki MATSUURA, ...
Article type: Article
1999 Volume 73 Issue 5-6 Pages
303-308
Published: May 25, 1999
Released on J-STAGE: December 26, 2017
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To understand the effects of lipid peroxides on physiological function of small intestine, rat small intestinal mucosa was incubated with 2, 2'-azobis (2-amidinopropane) dihydrochloride (AAPH), a free radical generator in aqueous phase, and changes in the level of lipid peroxidation, protein content, and enzymatic activities of maltase, lactate dehydrogenase (LDH) and mitochondrial dehydrogenase were analyzed. We also examined preventive effects of α-tocopherol and L-ascorbic acid against such changes. Incubation of small intestinal mucosa with AAPH resulted in the increase of thiobarbituric acid reactive substances (TBARS). Similar treatment induced reduction of the maltase activity. Addition of α-tocopherol and L-ascorbic acid prevented the increase of TBARS induced with AAPH, although the inhibitory effect on maltase level did not change unless 500 μg/mg protein of L-ascorbic acid was added. Likewise AAPH lowered the level of LDH and mitochondrial dehydrogenase activities, which was not influenced by α-tocopherol. These results demonstrate that AAPH treatment causes cellular damage, indicating that both lipids and proteins are attacked by free radicals. Further investigation is necessary to clear preventive effects of antioxidative vitamins against change in proteins and cellular injury caused with AAPH in small intestine.
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Fang SUN, Kozue IWAGUCHI, Reiko SHUDO, Yoshie NAGAKI, Kyoko TANAKA, Ka ...
Article type: Article
1999 Volume 73 Issue 5-6 Pages
309-310
Published: May 25, 1999
Released on J-STAGE: December 26, 2017
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[in Japanese]
Article type: Article
1999 Volume 73 Issue 5-6 Pages
311-312
Published: May 25, 1999
Released on J-STAGE: December 26, 2017
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[in Japanese], [in Japanese]
Article type: Article
1999 Volume 73 Issue 5-6 Pages
312-314
Published: May 25, 1999
Released on J-STAGE: December 26, 2017
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[in Japanese], [in Japanese]
Article type: Article
1999 Volume 73 Issue 5-6 Pages
314-315
Published: May 25, 1999
Released on J-STAGE: December 26, 2017
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[in Japanese]
Article type: Article
1999 Volume 73 Issue 5-6 Pages
315-317
Published: May 25, 1999
Released on J-STAGE: December 26, 2017
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Article type: Bibliography
1999 Volume 73 Issue 5-6 Pages
319-323
Published: May 25, 1999
Released on J-STAGE: December 26, 2017
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[in Japanese]
Article type: Article
1999 Volume 73 Issue 5-6 Pages
325-
Published: May 25, 1999
Released on J-STAGE: December 26, 2017
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[in Japanese], [in Japanese], Aldo Gutierrez, [in Japanese]
Article type: Article
1999 Volume 73 Issue 5-6 Pages
326-327
Published: May 25, 1999
Released on J-STAGE: December 26, 2017
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1999 Volume 73 Issue 5-6 Pages
327-328
Published: May 25, 1999
Released on J-STAGE: December 26, 2017
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[in Japanese]
Article type: Article
1999 Volume 73 Issue 5-6 Pages
328-330
Published: May 25, 1999
Released on J-STAGE: December 26, 2017
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1999 Volume 73 Issue 5-6 Pages
330-331
Published: May 25, 1999
Released on J-STAGE: December 26, 2017
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
1999 Volume 73 Issue 5-6 Pages
331-332
Published: May 25, 1999
Released on J-STAGE: December 26, 2017
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[in Japanese]
Article type: Article
1999 Volume 73 Issue 5-6 Pages
332-
Published: May 25, 1999
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
1999 Volume 73 Issue 5-6 Pages
332-333
Published: May 25, 1999
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[in Japanese]
Article type: Article
1999 Volume 73 Issue 5-6 Pages
333-334
Published: May 25, 1999
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[in Japanese]
Article type: Article
1999 Volume 73 Issue 5-6 Pages
335-
Published: May 25, 1999
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[in Japanese]
Article type: Article
1999 Volume 73 Issue 5-6 Pages
335-336
Published: May 25, 1999
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[in Japanese]
Article type: Article
1999 Volume 73 Issue 5-6 Pages
336-337
Published: May 25, 1999
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1999 Volume 73 Issue 5-6 Pages
337-339
Published: May 25, 1999
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[in Japanese]
Article type: Article
1999 Volume 73 Issue 5-6 Pages
339-340
Published: May 25, 1999
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[in Japanese]
Article type: Article
1999 Volume 73 Issue 5-6 Pages
340-
Published: May 25, 1999
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[in Japanese]
Article type: Article
1999 Volume 73 Issue 5-6 Pages
340-341
Published: May 25, 1999
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
1999 Volume 73 Issue 5-6 Pages
341-343
Published: May 25, 1999
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[in Japanese]
Article type: Article
1999 Volume 73 Issue 5-6 Pages
343-
Published: May 25, 1999
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[in Japanese]
Article type: Article
1999 Volume 73 Issue 5-6 Pages
345-346
Published: May 25, 1999
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
1999 Volume 73 Issue 5-6 Pages
346-347
Published: May 25, 1999
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[in Japanese], [in Japanese]
Article type: Article
1999 Volume 73 Issue 5-6 Pages
347-
Published: May 25, 1999
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[in Japanese]
Article type: Article
1999 Volume 73 Issue 5-6 Pages
349-350
Published: May 25, 1999
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[in Japanese]
Article type: Article
1999 Volume 73 Issue 5-6 Pages
350-
Published: May 25, 1999
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[in Japanese], [in Japanese]
Article type: Article
1999 Volume 73 Issue 5-6 Pages
351-352
Published: May 25, 1999
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]
Article type: Article
1999 Volume 73 Issue 5-6 Pages
352-
Published: May 25, 1999
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]
Article type: Article
1999 Volume 73 Issue 5-6 Pages
352-
Published: May 25, 1999
Released on J-STAGE: December 26, 2017
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]
Article type: Article
1999 Volume 73 Issue 5-6 Pages
352-353
Published: May 25, 1999
Released on J-STAGE: December 26, 2017
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
1999 Volume 73 Issue 5-6 Pages
353-
Published: May 25, 1999
Released on J-STAGE: December 26, 2017
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