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Volume 84, Issue 9
Displaying 1-19 of 19 articles from this issue
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Etsuo Niki, Mototada Shichiri, Yasukazu Yoshida, Hiroshi TamaiArticle type: Article
2010 Volume 84 Issue 9 Pages 415-422
Published: September 25, 2010
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSThe importance of neurological diseases has attracted much attention of the public as well as scientists from the viewpoints of both scientific and social problems. It has often been suggested that oxidative stress is involved in the pathogenesis of various neurological diseases and the preventive role of antioxidants, above all vitamin E analgues, has been the subjects of extensive studies and arguments. Despite numerous basic and clinical studies, the effects of oxidative stress and vitamin E have not been elucidated yet. Down syndrome (DS), characterized by trisomy of chromosome 21, is the most common genetic cause of mental retardation and precocious dementia. Recent studies suggest the involvement of oxidative stress in DS and beneficial effects of vitamin E in animal studies. In this article, the role of oxidative stress and vitamin E in DS will be critically reviewed.View full abstractDownload PDF (1159K) -
Hiroko Ikushiro, Yuka Shiraiwa, Hideyuki HayashiArticle type: Article
2010 Volume 84 Issue 9 Pages 423-431
Published: September 25, 2010
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSSerine palmitoyltransferase (SPT) is a key enzyme of sphingolipid biosynthesis and catalyzes the decarboxylative condensation of L-serine with palmitoyl-CoA to form 3-ketodihydrosphingosine. SPT belongs to the fold type I family of the pyridoxal 5'-phosphate (PLP)-dependent enzyme. SPT is different from most of the fold type I enzymes in that its re face of the PLP-Lys aldimine is occupied by a His residue (His159) instead of an aromatic amino acid residue. His159 was changed into alanine or aromatic amino acid residues in order to examine its role during catalysis. All mutant SPTs formed the PLP-L-serine aldimine and catalyzed the abortive transamination of L-serine. Only H159A SPT retained activity, and showed a prominent 505-nm absorption band of the quinonoid species during catalysis. Based on the results obtained from the kinetic analyses, we propose a novel mechanism, in which His159 plays multiple roles by exploiting the stereochemistry of the Dunathan's conjecture.View full abstractDownload PDF (1168K) -
Masaru SonodaArticle type: Article
2010 Volume 84 Issue 9 Pages 432-433
Published: September 25, 2010
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (275K) -
Akiko Amano, Akihito IshigamiArticle type: Article
2010 Volume 84 Issue 9 Pages 434-436
Published: September 25, 2010
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (429K) -
Kazuo SuekiArticle type: Article
2010 Volume 84 Issue 9 Pages 437-439
Published: September 25, 2010
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (540K) -
[in Japanese]Article type: Article
2010 Volume 84 Issue 9 Pages 440-441
Published: September 25, 2010
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (318K) -
[in Japanese]Article type: Article
2010 Volume 84 Issue 9 Pages 441-
Published: September 25, 2010
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (209K) -
[in Japanese]Article type: Article
2010 Volume 84 Issue 9 Pages 441-443
Published: September 25, 2010
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (600K) -
[in Japanese]Article type: Article
2010 Volume 84 Issue 9 Pages 443-445
Published: September 25, 2010
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (588K) -
[in Japanese]Article type: Article
2010 Volume 84 Issue 9 Pages 445-446
Published: September 25, 2010
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (351K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...Article type: Article
2010 Volume 84 Issue 9 Pages 447-
Published: September 25, 2010
Released on J-STAGE: October 10, 2017
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[in Japanese], [in Japanese]Article type: Article
2010 Volume 84 Issue 9 Pages 447-448
Published: September 25, 2010
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (363K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese]Article type: Article
2010 Volume 84 Issue 9 Pages 448-
Published: September 25, 2010
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (214K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...Article type: Article
2010 Volume 84 Issue 9 Pages 449-
Published: September 25, 2010
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (227K) -
[in Japanese], [in Japanese]Article type: Article
2010 Volume 84 Issue 9 Pages 450-
Published: September 25, 2010
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (229K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...Article type: Article
2010 Volume 84 Issue 9 Pages 450-451
Published: September 25, 2010
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (350K) -
[in Japanese]Article type: Article
2010 Volume 84 Issue 9 Pages 451-
Published: September 25, 2010
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (174K) -
[in Japanese]Article type: Article
2010 Volume 84 Issue 9 Pages 451-
Published: September 25, 2010
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (174K) -
Article type: Bibliography
2010 Volume 84 Issue 9 Pages 452-455
Published: September 25, 2010
Released on J-STAGE: October 10, 2017
JOURNAL FREE ACCESSDownload PDF (426K)
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