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Volume 57, Issue 9-10
Displaying 1-22 of 22 articles from this issue
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Keiya TADAArticle type: Article
1983 Volume 57 Issue 9-10 Pages 507-514
Published: October 25, 1983
Released on J-STAGE: March 10, 2018
JOURNAL FREE ACCESSKynureninase activity was investigated in the livers biopsied from the patients with B6 dependent xanthurenic aciduria. The activity was found to be markedly reduced but it was restored to a considerable extent by the addition of' an excess of pyridoxal phosphate to the assay system. This suggests that the basic defect in B_6 dependency is an inability of apoenzyme to combine with the coenzyme. Glycine cleavage system was investigated in the livers and brains autopsied from patients with nonketotic hyperglycinemia. The overall activity of the glycine cleavage system was found to be extremely low in both the liver and brain. A-nalyses of four protein components involved in glycine cleavage system revealed that nonketotic hyperglycinemia is caused by a specific defect in either pyridoxal phosphate-dependent protein or tetrahydrofolate-requiring protein. Key Words: B6 dependency, familial xanthurenic aciduria, hyperglycinemia, glycine cleavage reactionView full abstractDownload PDF (727K) -
Akira MURATA, Hikaru SUENAGA, Michiyo INOUE, Yoshihiro TANAKA, Fumio K ...Article type: Article
1983 Volume 57 Issue 9-10 Pages 515-521
Published: October 25, 1983
Released on J-STAGE: March 10, 2018
JOURNAL FREE ACCESSA duble-stranded RNA phage, φ6, has been found to be inactivated by ascorbic acid (ASA), and the reaction mechanism of inactivation of the phage by ASA has been studied. The addition of hydrogen peroxide or cupric ion into the reaction mixture enhanced the inactivation. In contrast, removal of oxygen from the reaction mixture, and the addition of reducing agents, chelating agents or general radical scavengers into the reaction mixture prevented the inactivation. Dehydroascorbic acid or hydrogen peroxide had no direct effect on the phage. The results indicate that the free radical intermediates produced during the course of the autoxidation of ASA are responsible for the inactivation of the phage; free radical mechanisms are involved in the inactivation reaction. The experiments using specific radical scavengers indicate that ・O_2, ・ OH and 1^O_2 are involved in the inactivation reaction, and that ・OH would be mainly responsible for the inactivating effect on the phage. Key Words: vitarnin C, ascorbic acid, double-stranded RNA phage, phage θ6, virus inactivationView full abstractDownload PDF (617K) -
Setsuko NODA, Michiko SUGIYAMA, Sachiko MORIUCHIArticle type: Article
1983 Volume 57 Issue 9-10 Pages 523-528
Published: October 25, 1983
Released on J-STAGE: March 10, 2018
JOURNAL FREE ACCESSThe effect of vitamin D3 and dietary calciurn on the cadmium-induced morpho-10gical changes in rat intestinal epithelial cells were examined by a transmission electron microscopy. Observation with transmission electron microscopy showed significant changes in cadmium-exposed rats, especially those raised on a vitamin D deflcient diet. Swelling and destruction of mitochondria, sparseness and exfoliation of microvilli, disappearance of terminal web were observed. Rough surfaced endoplasmic reticulum and Golgi apparcrtus were enlarged. Furthermore, many vacuoles were observed in epithelial cells. These changes vvere prevented in rats raised on a nor-mal calcium and vitamin D3 Supplemented diet. Key Words: vitamin D3, calcium, cadmium, cadmium-induced morphological change, intestineView full abstractDownload PDF (1792K) -
Tetsuo TORAYAArticle type: Article
1983 Volume 57 Issue 9-10 Pages 529-538
Published: October 25, 1983
Released on J-STAGE: March 10, 2018
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Article type: Appendix
1983 Volume 57 Issue 9-10 Pages 539-543
Published: October 25, 1983
Released on J-STAGE: March 10, 2018
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[in Japanese], [in Japanese], [in Japanese]Article type: Article
1983 Volume 57 Issue 9-10 Pages 545-
Published: October 25, 1983
Released on J-STAGE: March 10, 2018
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[in Japanese], [in Japanese]Article type: Article
1983 Volume 57 Issue 9-10 Pages 545-546
Published: October 25, 1983
Released on J-STAGE: March 10, 2018
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[in Japanese], [in Japanese], [in Japanese]Article type: Article
1983 Volume 57 Issue 9-10 Pages 547-
Published: October 25, 1983
Released on J-STAGE: March 10, 2018
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[in Japanese], [in Japanese]Article type: Article
1983 Volume 57 Issue 9-10 Pages 547-548
Published: October 25, 1983
Released on J-STAGE: March 10, 2018
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[in Japanese]Article type: Article
1983 Volume 57 Issue 9-10 Pages 548-
Published: October 25, 1983
Released on J-STAGE: March 10, 2018
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[in Japanese], [in Japanese]Article type: Article
1983 Volume 57 Issue 9-10 Pages 548-550
Published: October 25, 1983
Released on J-STAGE: March 10, 2018
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[in Japanese], [in Japanese], [in Japanese]Article type: Article
1983 Volume 57 Issue 9-10 Pages 550-
Published: October 25, 1983
Released on J-STAGE: March 10, 2018
JOURNAL FREE ACCESSDownload PDF (188K) -
[in Japanese], [in Japanese], [in Japanese]Article type: Article
1983 Volume 57 Issue 9-10 Pages 550-551
Published: October 25, 1983
Released on J-STAGE: March 10, 2018
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[in Japanese], [in Japanese]Article type: Article
1983 Volume 57 Issue 9-10 Pages 551-552
Published: October 25, 1983
Released on J-STAGE: March 10, 2018
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]Article type: Article
1983 Volume 57 Issue 9-10 Pages 552-
Published: October 25, 1983
Released on J-STAGE: March 10, 2018
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[in Japanese], [in Japanese], [in Japanese]Article type: Article
1983 Volume 57 Issue 9-10 Pages 552-553
Published: October 25, 1983
Released on J-STAGE: March 10, 2018
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[in Japanese], [in Japanese], [in Japanese]Article type: Article
1983 Volume 57 Issue 9-10 Pages 553-
Published: October 25, 1983
Released on J-STAGE: March 10, 2018
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[in Japanese]Article type: Article
1983 Volume 57 Issue 9-10 Pages 555-556
Published: October 25, 1983
Released on J-STAGE: March 10, 2018
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[in Japanese]Article type: Article
1983 Volume 57 Issue 9-10 Pages 556-557
Published: October 25, 1983
Released on J-STAGE: March 10, 2018
JOURNAL FREE ACCESSDownload PDF (318K) -
[in Japanese]Article type: Article
1983 Volume 57 Issue 9-10 Pages 557-558
Published: October 25, 1983
Released on J-STAGE: March 10, 2018
JOURNAL FREE ACCESSDownload PDF (301K) -
[in Japanese]Article type: Article
1983 Volume 57 Issue 9-10 Pages 558-560
Published: October 25, 1983
Released on J-STAGE: March 10, 2018
JOURNAL FREE ACCESSDownload PDF (409K) -
[in Japanese]Article type: Article
1983 Volume 57 Issue 9-10 Pages 560-561
Published: October 25, 1983
Released on J-STAGE: March 10, 2018
JOURNAL FREE ACCESSDownload PDF (230K)
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