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[in Japanese]
Article type: Article
2008 Volume 82 Issue 1 Pages
1-
Published: January 25, 2008
Released on J-STAGE: October 10, 2017
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Junko Okano
Article type: Article
2008 Volume 82 Issue 1 Pages
3-10
Published: January 25, 2008
Released on J-STAGE: October 10, 2017
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Vitamin A plays a key role in a variety of biological processes in adults and is essential for normal embryonic development. Retinoic acid (RA), an oxidation product of vitamin A, plays complex and diverse roles during embryogenesis but both excess and lack of RA is a potent teratogen in rodents and humans. Since the discovery of RA receptors in 1980's, various mutant mice have been reported including RA receptors, RA binding protein, and RA synthesizing or degrading enzymes to elucidate functions during embryogenesis. I would summarize these phenotypes of mutant mice and refer how RA plays important roles during normal development, especially focusing on hindbrain, vertebra, and limb development.
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Kazuhiro Yamada, Tetsunori Kawata, Akio Maekawa
Article type: Article
2008 Volume 82 Issue 1 Pages
11-17
Published: January 25, 2008
Released on J-STAGE: October 10, 2017
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It has been reported that vitamin B_<12> (B_<12>)-deficiency could cause testicular injury. The biochemical mechanism for this event, however, has not yet been fully understood. In mammals, B_<12> is a cofactor for two enzymes, i.e. methionine synthase and methylmalonyl-CoA mutase. According to earlier studies, methionine synthase, rather than methylmalonyl-CoA mutase, may be responsible for the testicular injury when animals are in B_<12>-deficiency. Methionine synthase is one of key enzymes in methionine and folate metabolism, which is important for nucleic acid synthesis, protein synthesis, polyamine synthesis, and transmethylation. Here, we describe that properties of methionine synthase and discuss a possible biochemical mechanism for the testicular injury due to B_<12>-deficiency.
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Natsuko Sato(Mito), Hidemi Takimoto
Article type: Article
2008 Volume 82 Issue 1 Pages
19-23
Published: January 25, 2008
Released on J-STAGE: October 10, 2017
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Folate is a water-soluble vitamin, which is one of vitamin B group, and is involved in DNA synthesis cycle and methylamine cycle. It is known that folate deficiency is associated with pernicious anemia. Folate is also an important nutrient for an embryo, because recent many studies reveal an association between maternal folate status and fetal neural tube defects (NTDs). In 2002, Japanese government recommended that all women planning a pregnancy should consume an additional 400μg/day of supplementary folate to reduce risk of NTDs, referring to scientific evidence and recommendations in the other countries. It is also reported that folate is an important nutrient for not only the prevention of NTDs but also health of mother and fetus. As the prevalence of NTDs was low in Japan compared with other countries in the past, folate status in Japanese has not been fully investigated. Folate has been recently added to the Dietary Reference Intake for Japanese and Standard Table of Food Composition in Japan since 2000.
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Momoko Chiba, Atsuko Shinohara
Article type: Article
2008 Volume 82 Issue 1 Pages
25-33
Published: January 25, 2008
Released on J-STAGE: October 10, 2017
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There have been investigated on the effect of minerals into reproduction of males. It has suggested that selenium (Se) and zinc(Zn) are key elements. Se has high correlation with sperm concentration and locates at the active center of phospholipid hydroperoxide glutathione peroxidase (PHGPx) which localizes in mitochondria and nuclei in sperm. Zn is more than 200 times higher in semen or seminal plasma than in sera. It may have important roles, however, extremely high Zn in seminal plasma reduces motility as well as extremely high copper (Cu). In reproduction of females Cu and manganese (Mn) are important. At present detail mechanisms are unclear, but Cu concentration in follicular fluids is 5 times higher than in semen, although the other element concentrations are lower than in semen. Mn concentration in follicular fluid correlates with estradiol (E2) values positively and with age negatively.
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Katsuhito Kino, Hiroshi Miyazawa, Hiroshi Sugiyama
Article type: Article
2008 Volume 82 Issue 1 Pages
35-37
Published: January 25, 2008
Released on J-STAGE: October 10, 2017
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Akihito Ishigami
Article type: Article
2008 Volume 82 Issue 1 Pages
39-42
Published: January 25, 2008
Released on J-STAGE: October 10, 2017
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Kazuo Sueki
Article type: Article
2008 Volume 82 Issue 1 Pages
43-45
Published: January 25, 2008
Released on J-STAGE: October 10, 2017
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Mieko Kimura
Article type: Article
2008 Volume 82 Issue 1 Pages
46-47
Published: January 25, 2008
Released on J-STAGE: October 10, 2017
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Chieri Ida, Shin Ogata, Hiroshi Taguchi
Article type: Article
2008 Volume 82 Issue 1 Pages
48-49
Published: January 25, 2008
Released on J-STAGE: October 10, 2017
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Kouichi Abe
Article type: Article
2008 Volume 82 Issue 1 Pages
50-52
Published: January 25, 2008
Released on J-STAGE: October 10, 2017
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Atsuko Takeuchi, Masako Tsukada, Akimori Wada
Article type: Article
2008 Volume 82 Issue 1 Pages
53-54
Published: January 25, 2008
Released on J-STAGE: October 10, 2017
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
2008 Volume 82 Issue 1 Pages
55-57
Published: January 25, 2008
Released on J-STAGE: October 10, 2017
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]
Article type: Article
2008 Volume 82 Issue 1 Pages
59-60
Published: January 25, 2008
Released on J-STAGE: October 10, 2017
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
2008 Volume 82 Issue 1 Pages
60-
Published: January 25, 2008
Released on J-STAGE: October 10, 2017
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
2008 Volume 82 Issue 1 Pages
61-
Published: January 25, 2008
Released on J-STAGE: October 10, 2017
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[in Japanese]
Article type: Article
2008 Volume 82 Issue 1 Pages
61-62
Published: January 25, 2008
Released on J-STAGE: October 10, 2017
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[in Japanese]
Article type: Article
2008 Volume 82 Issue 1 Pages
62-63
Published: January 25, 2008
Released on J-STAGE: October 10, 2017
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
2008 Volume 82 Issue 1 Pages
63-64
Published: January 25, 2008
Released on J-STAGE: October 10, 2017
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[in Japanese]
Article type: Article
2008 Volume 82 Issue 1 Pages
64-65
Published: January 25, 2008
Released on J-STAGE: October 10, 2017
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[in Japanese]
Article type: Article
2008 Volume 82 Issue 1 Pages
65-
Published: January 25, 2008
Released on J-STAGE: October 10, 2017
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
2008 Volume 82 Issue 1 Pages
66-
Published: January 25, 2008
Released on J-STAGE: October 10, 2017
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[in Japanese]
Article type: Article
2008 Volume 82 Issue 1 Pages
66-68
Published: January 25, 2008
Released on J-STAGE: October 10, 2017
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[in Japanese], [in Japanese]
Article type: Article
2008 Volume 82 Issue 1 Pages
68-
Published: January 25, 2008
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[in Japanese]
Article type: Article
2008 Volume 82 Issue 1 Pages
69-70
Published: January 25, 2008
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[in Japanese]
Article type: Article
2008 Volume 82 Issue 1 Pages
70-71
Published: January 25, 2008
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[in Japanese]
Article type: Article
2008 Volume 82 Issue 1 Pages
71-
Published: January 25, 2008
Released on J-STAGE: October 10, 2017
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[in Japanese]
Article type: Article
2008 Volume 82 Issue 1 Pages
72-
Published: January 25, 2008
Released on J-STAGE: October 10, 2017
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[in Japanese]
Article type: Article
2008 Volume 82 Issue 1 Pages
72-74
Published: January 25, 2008
Released on J-STAGE: October 10, 2017
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[in Japanese]
Article type: Article
2008 Volume 82 Issue 1 Pages
74-75
Published: January 25, 2008
Released on J-STAGE: October 10, 2017
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
2008 Volume 82 Issue 1 Pages
75-
Published: January 25, 2008
Released on J-STAGE: October 10, 2017
JOURNAL
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