All issues
Volume 90, Issue 2
Displaying 1-10 of 10 articles from this issue
- |<
- <
- 1
- >
- >|
-
Shuhei EbaraArticle type: Article
2016 Volume 90 Issue 2 Pages 61-67
Published: February 25, 2016
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSVitamin B_<12> (B_<12>) is an essential nutrient and functions as the coenzyme for methylmalonyl-CoA mutase and methionine synthase in mammals. B_<12> deficiency has been reported to cause growth retardation and severe hematological and neurological abnormalities. However, the biochemical mechanisms for these abnormalities caused by B_<12> deficiency are poorly understood. In the present study, therefore, metabolic abnormalities caused by B_<12> deficiency were examined using B_<12>-deficient rats as an experimental B_<12>-deficient model. The following findings were indicated in this study; (1) amino acid metabolism in rats was disordered by B_<12> deficiency and, in particular, serine and threonine in the plasma and urine were abnormally increased by the deficiency, (2) the expression of serine dehydratase participating in the metabolism of serine and threonine in liver was significantly lowered by B_<12> deficiency without no direct involvement of B_<12> in the enzyme reaction, (3) these abnormalities were consequently induced by impairment of glucagon signal transduction activating adenylyl cyclase system. In addition, it was found that a megaloblastic anaemia-like symptom was induced when the B_<12> deficient rats were exposed to hypoxia.View full abstractDownload PDF (800K) -
Teruo MiyazawaArticle type: Article
2016 Volume 90 Issue 2 Pages 68-76
Published: February 25, 2016
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSThe antiangiogenic and anticancer functions of tocotrienol (an unsaturated vitamin E) were discovered, and their molecular mechanisms were clarified in studies using cell cultures and experimental animals. Tocotrienol inhibits hypoxia-induced vascular endothelial growth factor secretion, and suppresses vascular endothelial growth factor and interlukin-8 expression at both mRNA and protein levels in tumor cells. The physiological functions of tocotrienol based on its intestinal absorption, its tissue organ distribution, its skin anti-inflammation and its improved lipid metabolism were also explained. The tocotrienol-rich rice plant strain was established, and the daily intake of tocotrienol in Japanese population and the safety of dietary intake of tocotrienol were confirmed. These investigations indicate the physiological significance of tocotrienol ingestion as a fat-soluble vitamin and a functional component in food products.View full abstractDownload PDF (4600K) -
Yuki Aoyama, Hiromi Sawamura, Masahiro Yuasa, Shuhei Ebara, Toshiaki W ...Article type: Article
2016 Volume 90 Issue 2 Pages 77-82
Published: February 25, 2016
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSWe investigated the effects of biotin deficiency on the sense of taste in rats. Male wistar rats aged 3 weeks, were divided into three groups: Control group (C), pair-fed group (PF) and biotin-deficient (BD) group. All rats in the three groups were fed for Sweeks. 48-h two-bottle preference test was conducted on the 3-4th and 7-8th week of each feeding. Food intake and body weight were decreased from the 3rd week in the BD group. Plasma and liver biotin levels were significantly decreased in the BD group. The 48-h preference test showed that the preference ratios for salty taste at 300 and 500 mM NaCl on the 3rd week were relatively higher in the BD group than in the C and PF groups. However, there were no significant differences in the preference ratios for salty taste on the 7th week among the three groups. For the bitter taste test on the 4th week, the preference ratios at all concentrations of caffeine used were relatively higher in the BD group than in the C and PF groups. On the 8th week, the preference ratio for bitter taste at 3 mM caffeine was higher in the BD group than in the PF group. These results indicate that biotin deficiency has an effect on the sense of taste in rats. The results also suggest the possibility that the recognition threshold value for taste is increased in BD rats.View full abstractDownload PDF (2693K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...Article type: Article
2016 Volume 90 Issue 2 Pages 83-84
Published: February 25, 2016
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (304K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...Article type: Article
2016 Volume 90 Issue 2 Pages 84-85
Published: February 25, 2016
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (314K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...Article type: Article
2016 Volume 90 Issue 2 Pages 85-
Published: February 25, 2016
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (201K) -
[in Japanese], [in Japanese]Article type: Article
2016 Volume 90 Issue 2 Pages 85-86
Published: February 25, 2016
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (346K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...Article type: Article
2016 Volume 90 Issue 2 Pages 86-87
Published: February 25, 2016
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (349K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...Article type: Article
2016 Volume 90 Issue 2 Pages 87-89
Published: February 25, 2016
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (397K) -
Article type: Bibliography
2016 Volume 90 Issue 2 Pages 90-95
Published: February 25, 2016
Released on J-STAGE: December 26, 2017
JOURNAL FREE ACCESSDownload PDF (522K)
- |<
- <
- 1
- >
- >|