VITAMINS

Online ISSN : 2424-080X
Print ISSN : 0006-386X

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Volume 31, Issue 5

Displaying 1-37 of 37 articles from this issue

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ROLE OF NICOTINAMIDE ADENINE DINUCLEOTDE PHOSPHATE IN THE REGULATION OF RESPIRATORY METABOLISM

Yukio YAMAMOTO

Article type: Article
1965 Volume 31 Issue 5 Pages 343-355
Published: May 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.31.5_343

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[title in Japanese]

[in Japanese]

Article type: Article
1965 Volume 31 Issue 5 Pages 355-
Published: May 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.31.5_355_2

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BIOGENESIS OF VITAMIN B_6 IN CANDIDA ALBICANS 4888 : (I) EFFECT OF α-AMINO ACIDS AS A SOLE SOURCE OF CARBON

Kazuo SATO, Takao SUZUKI, Yoshikazu SAHASHI

Article type: Article
1965 Volume 31 Issue 5 Pages 356-358
Published: May 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.31.5_356

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In the studies of biogenesis of pyridoxal by Candida albicans 4888,the availability of various amino acids as a sole source of carbon was investigated. Proline, arginine, alanine, asparatic acid and glutamic acid tupported the growth of yeast and the remarkable production of pyridoxal was observed in case of the latter two. Fumaric acid was considerably accumulated in the medium containing asparatic acid.

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BIOGENESIS OF VITAMIN B_6 IN CANDIDA ALBICANS 4888 : (II) EFFECT OF ORGANIC ACIDS AS A SOLE OF CARBON

Kazuo SATO, Takao SUZKI, Yoshikazu SAHASHI

Article type: Article
1965 Volume 31 Issue 5 Pages 359-361
Published: May 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.31.5_359

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In the studies of biogenesis of pyridoxal by Candida albicans 4888,the availability of various organic acids as carbon source was investigated. Carboxylic acids in Krebs' cycle as a sole source of carbon supported the growth of the yeast and the remarkable amount of pyridoxal was produced when malic acid or citric acid was used. It was recognized that fumaric acid was accumulated in the yeast celll especially in the case of malic acid was used as carbon source.

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THIN LAYER CHROMATOGRAPHY OF VITAMIN B_<12>

Tadashi KAMIKUBO, Mitsunori HAYAHI

Article type: Article
1965 Volume 31 Issue 5 Pages 362-368
Published: May 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.31.5_362

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Thin layer chromatography was investigated using inorganic as well as organic adsorbents with special reference to vitamin B_<12>. The reference standards of vitamin B_<12> analogues used were cyano-and hydroxo-cobalamin, pseudo-vitamin B_<12>, factors A, B, and III. Adsorbents examined were Aluminium oxide G, Kieselgel G, and Kieselgur G as inorganic ones, and P-and DEAE-cellulose as organic ionexchangers. It seems that each adsorbent requires adequate solvent systems for a selective separation of each vitamin B_<12> factor, and can be practically used depending upon the purpose. The conditions for improving separation were also discussed.

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ON THE EFFECTS OF PANTOTHENIC ACID AND PANTETHINE ON THE ABNORMAL LIPID METABOLISM OF LIVER IN PANTOTHENIC ACID-DEFICIENT RAT

Kyugo ONOE, Minoru MATSUNAGA, Osamu NISHIMURA

Article type: Article
1965 Volume 31 Issue 5 Pages 369-372
Published: May 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.31.5_369

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The effects of pantothenic acid and pantethine were compaired for the urinary acetylating potency and improvement of fat metabolism in liver of pantothenic acid-deficient rat. Pantethine had a superior effect than pantothenic acid for the normalization of urinary acetylating potency. For the improvement of phospholipid metabolism and cholesterol value of liver were observed in pantothenic acid and pantethine administration, however the effect was significant in the latter. The recovery of abnormal liver fatty acid composition was achieved by the latter, while the former had no effect.

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[title in Japanese]

[in Japanese]

Article type: Article
1965 Volume 31 Issue 5 Pages 372-
Published: May 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.31.5_372_2

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ON THE EFFECT OF PANTETHINE ON THE TREATMENT OF PATIENTS WITH LIVER DISEASES

Kyugo ONOE, Osamu NISHIMURA, Toshimasa HUKUDA, Akiyoshi BANDO

Article type: Article
1965 Volume 31 Issue 5 Pages 373-379
Published: May 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.31.5_373

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Twenty-six patients with various liver diseases were treated with 60-120mg of pantethine daily for 30 days. The subjective symptoms were ameliorated or disappeared and the liver function was improved in many cases. Side effect was not observed in all cases.

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STUDIES IN THE TRYPTOPHAN METABOLISM IN PATIENT OF CUSHING'S SYNDROME

Toshio OKINAKA

Article type: Article
1965 Volume 31 Issue 5 Pages 380-386
Published: May 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.31.5_380

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Tryptophan and it's metabolites, such as kynurenine, kynurenic acid, N-methylpyridone carboxamide in 24 hours urine were determined after an oral administration of 2g of L-tryptophan in patient of Cushing's syndrome. Increases of urinary kynurenine and N-methylpyridone carboxamide were observed in these patients before operation, but after the total adrenalectomy or removal of tumor, the excretion of tryptophan metabolites returned to normal. The convertion rate of tryptophan was revealed to be very high in Cushing's patients. When pyridoxal phosphate was given to these patients, the urinary excretion of kynurenine, kynurenic acid and xanthurenic acid decreased, both in before and after the operation, while N-methylpyridone carboxamide increased.

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THE RELATION BETWEEN THIAMINE AND VITAMIN B_6 ON SACCHAROMYCES CARLSBERGENSIS 4228 : (III) EFFECTS OF COMPOUNDS RELATED TO THIAMINE ON THE GROWTH OF THIAMINE-ADAPTED SACCH.CARLSBERGENSIS

Chikataro KAWASAKI, Takeo KISHI, Atsuko NIINOMI, Shihoko IKENAGA

Article type: Article
1965 Volume 31 Issue 5 Pages 387-392
Published: May 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.31.5_387

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The growth of Sacch.carlsbergensis 4228 was inhibited by the presence of thiamine or some of its derivatives, but it was stimulated when the incubation time was prolonged. The adaptation of this organism was tried to 1 or 100μg of thiamine per 4ml broth and the growth of these thiamine-adapted yeasts was tested at the presence of compounds related to thiamine. Despite that thiamine diphosphate, thiamine monophosphate, benzoylthiamine monophosphate, thiamine disulfide, thiamine propyldisulfide and so on were shown to be inhibitory to the growth of normal yeast, these compounds never inhibited the growth of the thiamine-adapted yeasts. Other thiamine derivatives such as S-carbethoxythiamine, dibenzoylthiamine and O-benzoylthiamine disulfide were proved to be stimualative to the growth of the thiamine-adapted yeasts as well as of normal yeast. About antithiamine compounds, pyrithiamine, oxythiamine and imidazolethiamine inhibited the growth of both types of yeast, while deoxythiamine, 5-methylthiamine and thiamine sulfuric ester did not.

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THE RELATION BETWEEN THIAMINE AND VITAMIN B_6 ON SACCHAROMYCES CARLSBERGENSIS 4228 : (IV) THE UTILIZATION OF NITROGEN SOURCES AT THE PRESENCE OR AT THE ABSENCE OF THIAMINE AND VITAMIN B_6

Chikataro KAWASAKI, Takeo KISHI, Tsutomu NISHIHARA

Article type: Article
1965 Volume 31 Issue 5 Pages 393-397
Published: May 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.31.5_393

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When thiamine was added to the broth without pyridoxine, Saccharomyces carlsbergensis 4228 was shown to have a retarded growth in the broth containing casamino acids, ammonium sulfate, L-glutamine, L-glutamic acid or L-asparagine as N sources, but when both thiamine and pyridoxine were added to the broth, it showed a complete recovery of the growth. Thiamine-adapted Sacch.carlsbergensis (B_1-1 and B_1-100) and Sacch.cerevisiae Hansen were proved to show similar growth in the broths containing casamino acids or other N sources, either at the presence or at the absence of thiamine in the broths. At the presence of pyridoxine in the broth without thiamine, all the 4 strains of yeasts were able to grow similarly but the growth was slower than that in the broth with both. The utilization of casamino acids, ammonium sulfate and L-asparagine by Sacch. carlsbergensis in the broth with thiamine and pyridoxine was proved to be same, when N content of each was, or less than 0.5mg per tube.

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EFFECT OF THIAMINE TETRAHYDROFURFURYLDISUIFIDE UPON THE INTESTINAL MOTILITY

Takesi HUKUHARA, Ryozi NANBA, Hirosi SIINA

Article type: Article
1965 Volume 31 Issue 5 Pages 398-400
Published: May 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.31.5_398

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On non-anesthetized dogs provided with the normal, denervated and aganglionic Thiry-Vella jejunal loops, the effect of thiamine tetrahydrofurfuryldisulfide (TTFD) upon the intestinal motility was studied. On the normal and denervated loops the intravenous administration of 1.5mg/kg of TTFD produced a slight rise of tone and a remarkable increase of the amplitude of rhythmic contractions for about 20 minutes or longer. In the animal anesthetized with 25 mg/kg of sodium pentobarbital, the drug also increased the motility of the normal and denervated loops as remarkably as in the animal non-anesthetized. The drug exerted no action upon the aganglionic loop. A small amount (1ml) of 5% TTFD solution which was carefully introduced into the intestinal lumen, stimulated the mucosa to elicit the mucosal intrinsic reflex the effect of which consisted of an excitation above and an inhibition below the stimulated spot. The probable site of action of the drug was discussed.

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THE MECHANISM OF INTESTINAL ABSORPTION OF THIAMINE AND THIAMINE PROPYLDISULFIDE

Kunio YOSHIKAWA

Article type: Article
1965 Volume 31 Issue 5 Pages 401-415
Published: May 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.31.5_401

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Studies were made on the reason why the absorption of thiamine propyldisulfide (TPD) through the intestinal wall is considerably accelerated as compared with thiamine. The experiment was made with dog's ileum which was separated from the other part and of which the mesenteric vein is cannulated to collect the blood sample. One hour after administration of the sample in the loop of intestine, the content was washed out and the rate of absorption was estimated. It was demonstrated that the large part of the absorbed thiamine was retained in the intestinal wall, while TPD was transferred into the blood. From the experiments with metabolic inhibitors, it was inferred that the absorption of thiamine through the inner surface of intestinal epithelium (first process) is effected by active as well as passive process, and the transport through the cell menbrane into the Lamina propria and blood capillaries (second process) mainly by passive process, while the first process of TPD is mainly effected by passive diffusion, and the second process by active process.

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[title in Japanese]

[in Japanese], [in Japanese]

Article type: Article
1965 Volume 31 Issue 5 Pages 416-
Published: May 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.31.5_416_1

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[title in Japanese]

[in Japanese], [in Japanese]

Article type: Article
1965 Volume 31 Issue 5 Pages 416-
Published: May 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.31.5_416_2

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[title in Japanese]

[in Japanese], [in Japanese]

Article type: Article
1965 Volume 31 Issue 5 Pages 416-417
Published: May 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.31.5_416_3

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese]

Article type: Article
1965 Volume 31 Issue 5 Pages 417-
Published: May 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.31.5_417

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese]

Article type: Article
1965 Volume 31 Issue 5 Pages 418-
Published: May 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.31.5_418_1

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese]

Article type: Article
1965 Volume 31 Issue 5 Pages 418-419
Published: May 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.31.5_418_2

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[title in Japanese]

[in Japanese], [in Japanese]

Article type: Article
1965 Volume 31 Issue 5 Pages 419-
Published: May 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.31.5_419_1

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese]

Article type: Article
1965 Volume 31 Issue 5 Pages 419-420
Published: May 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.31.5_419_2

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese]

Article type: Article
1965 Volume 31 Issue 5 Pages 420-
Published: May 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.31.5_420_1

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[title in Japanese]

[in Japanese], [in Japanese]

Article type: Article
1965 Volume 31 Issue 5 Pages 420-421
Published: May 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.31.5_420_2

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[title in Japanese]

[in Japanese]

Article type: Article
1965 Volume 31 Issue 5 Pages 421-422
Published: May 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.31.5_421

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese]

Article type: Article
1965 Volume 31 Issue 5 Pages 422-
Published: May 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.31.5_422_1

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[title in Japanese]

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Article type: Article
1965 Volume 31 Issue 5 Pages 422-423
Published: May 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.31.5_422_2

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[title in Japanese]

[in Japanese], [in Japanese]

Article type: Article
1965 Volume 31 Issue 5 Pages 423-
Published: May 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.31.5_423_1

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese]

Article type: Article
1965 Volume 31 Issue 5 Pages 423-
Published: May 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.31.5_423_2

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese]

Article type: Article
1965 Volume 31 Issue 5 Pages 423-424
Published: May 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.31.5_423_3

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[title in Japanese]

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Article type: Article
1965 Volume 31 Issue 5 Pages 424-
Published: May 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.31.5_424_1

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese]

Article type: Article
1965 Volume 31 Issue 5 Pages 424-425
Published: May 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.31.5_424_2

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[title in Japanese]

[in Japanese], [in Japanese]

Article type: Article
1965 Volume 31 Issue 5 Pages 425-
Published: May 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.31.5_425_1

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese]

Article type: Article
1965 Volume 31 Issue 5 Pages 425-426
Published: May 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.31.5_425_2

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[title in Japanese]

[in Japanese]

Article type: Article
1965 Volume 31 Issue 5 Pages 426-
Published: May 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.31.5_426_1

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[title in Japanese]

[in Japanese]

Article type: Article
1965 Volume 31 Issue 5 Pages 426-427
Published: May 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.31.5_426_2

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[title in Japanese]

[in Japanese], [in Japanese]

Article type: Article
1965 Volume 31 Issue 5 Pages 427-
Published: May 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.31.5_427_1

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[title in Japanese]

[in Japanese], [in Japanese]

Article type: Article
1965 Volume 31 Issue 5 Pages 427-428
Published: May 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.31.5_427_2

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