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Minoru HIROOKA, Hiroshi WAKO
Article type: Article
1972 Volume 46 Issue 5 Pages
219-226
Published: November 25, 1972
Released on J-STAGE: February 27, 2018
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Referring to the historical background of the policies for prevention of rickets in Great Britain and U. S. A. etc., we proposed the following new policies for prevention of rickets in Japan. 1) The daily prophylactic requirement of vitamin D for infants and children should be of the order of 400 to 800IU. 2) Regular vitamin D supplements should be provided to breast-fed infants. 3) In order to avoid complexity of instruction for the mothers concerning regular supply of vitamin D and iatrogenic rickets in low-birth-infants due to small amount of formula ingested, resulting in low daily vitamin D intake regular vitamin D supplements should be recommended even for the infants bottle-fed or mixed with the vitamin D fortified milk. 4) The vitamin D levels of fortification in dried milk should be reduced to 266-300IU per 100g (40-45IU per 100ml) from 500-600IU per 100g of present milk preparations.
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Teruo SAITO
Article type: Article
1972 Volume 46 Issue 5 Pages
227-231
Published: November 25, 1972
Released on J-STAGE: February 27, 2018
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The effects of riboflavin derivatives on the common carotid, femoral, renal, great auricular, coronary, and mesenteric arteries were studied in dogs anesthetized with pentobarbital. 1) FMN exerted no appreciable effects on any of the blood vessels tested. 2) FAD markedly constricted the renal artery, while it markedly dilated the common carotid, femoral, and coronary arteries. FAD also slightly dilated the great auricular and cranial mesenteric arteries. 3) DNRP dilated the great auricular, coronary, and cranial mesenteric arteries, while it constricted the renal artery. The degree of the renal artery constriction, however, was smaller than that produced by FAD. DNRP little affected the common carotid and femoral arteries. 4) NiA dilated the great auricular artery, but did not influence other blood vessels tested.
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Choten INAGAKI, Nobuhiko ARAKAWA
Article type: Article
1972 Volume 46 Issue 5 Pages
233-238
Published: November 25, 1972
Released on J-STAGE: February 27, 2018
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The antiscorbutic activity of various lauroyl ascorbic acid (Lau-AsA) has been compared with that of ascorbic acid (AsA) by the oral administration of 1.0mg and 0.5mg AsA equivalent to guinea pigs. It has been shown that 2-mono-Lau-AsA, 6-mono-Lau-AsA, 2,6-di-Lau-AsA, 2,5,6-tri-Lau-AsA, and 2,3,5,6-tetra-Lau-AsA are effective in turn, that 2-mono-Lau-AsA and 6-mono-Lau-AsA have almost the same activity as that of AsA, and that 2,3,5,6-tetra-Lau-AsA has also some activity, though it is the lowest among the samples. These results showed a good coincidence with those of enzymatic hydrolysis of Lau-AsA by pancreas and liver homogenates. It appears that the esterification of 6-, or 5- and 6-hydroxy group rather than that of 2-hydroxy group of AsA results in a decrease of the antiscorbutic activity.
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Kikuko INOUE
Article type: Article
1972 Volume 46 Issue 5 Pages
239-243
Published: November 25, 1972
Released on J-STAGE: February 27, 2018
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Although, in previous paper, the auther reported that rat liver had an enzyme converting O-benzoylthiamine (OBT) to thiamine, it is now found to be corrected. In the present report, it was clarified that liver homogenates of rat had the enzyme capable of converting OBT to B_1-thiazolone as reported by Utsumi et al. On the other hand, enzymes in brain, heart, kidneys and blood convert OBT to thiamine.
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Kikuko INOUE, Yoshinori ITOKAWA
Article type: Article
1972 Volume 46 Issue 5 Pages
245-249
Published: November 25, 1972
Released on J-STAGE: February 27, 2018
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To clarify the thiamine activity of O-benzoylthiamine and thiamine-thiazolone, O-benzoylthiamine or thiamine-thiazolone were given orally or parenterally to Wistar rats which on the thiamine deficient diet. The results obtained were as follows : (1) In thiamine-thiazolone administered rats by either oral or parenteral administration, growth was depressed markedly. While, In O-benzoylthiamine administered groups, good growth was observed. (2) Thiamine concentration in liver, kidneys, brain and blood decreased significantly in thiamine-thiazolone administered groups. In O-benzoylthiamine administered rats, liver thiamine levels decreased slightly and no significant change was observed in thiamine levels of other tissues. (3) Transketolase activities in liver of thiamine-thiazolone administered rats decreased markedly and that of O-benzoylthiamine administered rats decreased slightly. In vitro addition of thiamine diphosphate to liver homogenate of these rats resulted in a recovery of transketolase activity.
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Ryosuke KIKUCHI, Shinichi HAREYAMA
Article type: Article
1972 Volume 46 Issue 5 Pages
251-253
Published: November 25, 1972
Released on J-STAGE: February 27, 2018
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The Vitamin B_<12> contents (mμg/ml) in serum of Hereford, Japanese Shorthorn, and Japanese Black Cattle were 0.41〜0.46,0.40〜0.45 and 0.25〜0.31 respectively. Japanese Black Cattle showed a significantly low B_<12> content as compared with that of Hereford and Japanese Shorthorn, although the growth was normal under the conditions.
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Kenzo TSUJITA
Article type: Article
1972 Volume 46 Issue 5 Pages
255-260
Published: November 25, 1972
Released on J-STAGE: February 27, 2018
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There was no difference between the effects of injection of pantothenic acid (PaA), pantethine (PaSS) or CoA on the hepatic CoA content in PaA deficient rats. The decreased content of CoA in homopantothenic acid administered or protein deficient rat liver was recoverd by the injection of PaA, PaSS or CoA. The recovering effects of PaSS and CoA were almost same and were greater than that of PaA. Therefore, it is suggested that pantetheine seems to be the most likely compound to penetrate into the liver cell.
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Isamu MASUGI
Article type: Article
1972 Volume 46 Issue 5 Pages
261-265
Published: November 25, 1972
Released on J-STAGE: February 27, 2018
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The methods of the measurement of free form and bound form pantothenic acid (PaA) were studied and PaA in blood and urine of the children in each age was measured. The bacteriological method of Skeggs-Wright using Lactobacillus arabinosus was applied to measure PaA. The decomposition of bound form was carried out according to the method reported by Novelli et al.. The following results were obtained on the studies of PaA metabolism in childhood. The total PaA existed in extremely high level in cord blood and new born baby's blood, and decreased with ages. The free type PaA was also in higher level in the children of younger age. The level of PaA in urine was also measured in the children with age 4 to 16. The average value in 24 hours urine was calculated to be 1.8〜3.0 mg which was lower compared with the average value of 2.6〜5.7 mg obtained from the data of the adult.
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Isamu MASUGI
Article type: Article
1972 Volume 46 Issue 5 Pages
267-271
Published: November 25, 1972
Released on J-STAGE: February 27, 2018
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The level of pantothenic acid (PaA) in the tissues such as liver, kidney and brain were measured in young rats on the subsequent days after birth. The total PaA in liver and kidney was increased with days, to reach the highest level in 30〜40 days after birth. On the other hand, in brain it was remained within same level regardless of days after birth. The free type was dominant in the level compared with the bound form in kidney.
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[in Japanese], [in Japanese]
Article type: Article
1972 Volume 46 Issue 5 Pages
273-
Published: November 25, 1972
Released on J-STAGE: February 27, 2018
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[in Japanese], [in Japanese]
Article type: Article
1972 Volume 46 Issue 5 Pages
273-274
Published: November 25, 1972
Released on J-STAGE: February 27, 2018
JOURNAL
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[in Japanese], [in Japanese]
Article type: Article
1972 Volume 46 Issue 5 Pages
274-
Published: November 25, 1972
Released on J-STAGE: February 27, 2018
JOURNAL
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
1972 Volume 46 Issue 5 Pages
274-275
Published: November 25, 1972
Released on J-STAGE: February 27, 2018
JOURNAL
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
1972 Volume 46 Issue 5 Pages
277-
Published: November 25, 1972
Released on J-STAGE: February 27, 2018
JOURNAL
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]
Article type: Article
1972 Volume 46 Issue 5 Pages
277-278
Published: November 25, 1972
Released on J-STAGE: February 27, 2018
JOURNAL
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
1972 Volume 46 Issue 5 Pages
278-279
Published: November 25, 1972
Released on J-STAGE: February 27, 2018
JOURNAL
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]
Article type: Article
1972 Volume 46 Issue 5 Pages
279-280
Published: November 25, 1972
Released on J-STAGE: February 27, 2018
JOURNAL
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
1972 Volume 46 Issue 5 Pages
280-281
Published: November 25, 1972
Released on J-STAGE: February 27, 2018
JOURNAL
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]
Article type: Article
1972 Volume 46 Issue 5 Pages
281-
Published: November 25, 1972
Released on J-STAGE: February 27, 2018
JOURNAL
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]
Article type: Article
1972 Volume 46 Issue 5 Pages
281-
Published: November 25, 1972
Released on J-STAGE: February 27, 2018
JOURNAL
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1972 Volume 46 Issue 5 Pages
281-282
Published: November 25, 1972
Released on J-STAGE: February 27, 2018
JOURNAL
FREE ACCESS