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Yasutoshi MUTO
Article type: Article
1986 Volume 60 Issue 10 Pages
481-492
Published: October 25, 1986
Released on J-STAGE: March 14, 2018
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Retinol-binding protein (RBP), isolated from serum of young yellow tail, was distinctly different from mammalian and avian RBPs,, in terms of a lack of binding site for prealbumin on the molecule of piscine RBP, circulating as a monomeric form. Hence, phylogenetic development of serum RBP and intracellular binding proteins for retinoids was also examined: A new molecular species, designated cellular retinoid-binding protein, F-type or CRBP(F), was found initially in fish eye cytosol, later in developing chick embryo brain as well as at a certain stage of regenerating rat liver. Moreover, CRBP(F) was considered to be one of oncofetal proteins, since the protein was detected in human fetal liver as well as in human hepatoma and experimentally induced hepatomas in rats and mice. By means of binding affinity to the receptor protein, a novel polyprenoic acid derivative: 3, 7, 11, 15-tetramethyl-2, 4, 6, 10, 14-hexadecapentaenoic acid was discovered and proved to have antitumor activity in experimental skin papilloma and hepatocarcinogenesis with better therapeutic index than those of previously known synthetic retinoids. Thus, the author has proposed a new naming of "Acyclic Retinoids" for the polyprenoic acid without any aromatic rings in the molecule.
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Article type: Bibliography
1986 Volume 60 Issue 10 Pages
493-495
Published: October 25, 1986
Released on J-STAGE: March 14, 2018
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[in Japanese], [in Japanese]
Article type: Article
1986 Volume 60 Issue 10 Pages
497-498
Published: October 25, 1986
Released on J-STAGE: March 14, 2018
JOURNAL
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
1986 Volume 60 Issue 10 Pages
498-
Published: October 25, 1986
Released on J-STAGE: March 14, 2018
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[in Japanese], [in Japanese], D.E.M. Lawson
Article type: Article
1986 Volume 60 Issue 10 Pages
498-499
Published: October 25, 1986
Released on J-STAGE: March 14, 2018
JOURNAL
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]
Article type: Article
1986 Volume 60 Issue 10 Pages
499-
Published: October 25, 1986
Released on J-STAGE: March 14, 2018
JOURNAL
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
1986 Volume 60 Issue 10 Pages
499-500
Published: October 25, 1986
Released on J-STAGE: March 14, 2018
JOURNAL
FREE ACCESS
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[in Japanese]
Article type: Article
1986 Volume 60 Issue 10 Pages
500-
Published: October 25, 1986
Released on J-STAGE: March 14, 2018
JOURNAL
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[in Japanese], [in Japanese]
Article type: Article
1986 Volume 60 Issue 10 Pages
501-502
Published: October 25, 1986
Released on J-STAGE: March 14, 2018
JOURNAL
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[in Japanese], [in Japanese]
Article type: Article
1986 Volume 60 Issue 10 Pages
502-503
Published: October 25, 1986
Released on J-STAGE: March 14, 2018
JOURNAL
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1986 Volume 60 Issue 10 Pages
503-504
Published: October 25, 1986
Released on J-STAGE: March 14, 2018
JOURNAL
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[in Japanese]
Article type: Article
1986 Volume 60 Issue 10 Pages
504-
Published: October 25, 1986
Released on J-STAGE: March 14, 2018
JOURNAL
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[in Japanese]
Article type: Article
1986 Volume 60 Issue 10 Pages
504-505
Published: October 25, 1986
Released on J-STAGE: March 14, 2018
JOURNAL
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1986 Volume 60 Issue 10 Pages
507-
Published: October 25, 1986
Released on J-STAGE: March 14, 2018
JOURNAL
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]
Article type: Article
1986 Volume 60 Issue 10 Pages
507-508
Published: October 25, 1986
Released on J-STAGE: March 14, 2018
JOURNAL
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
1986 Volume 60 Issue 10 Pages
508-
Published: October 25, 1986
Released on J-STAGE: March 14, 2018
JOURNAL
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[in Japanese]
Article type: Article
1986 Volume 60 Issue 10 Pages
509-510
Published: October 25, 1986
Released on J-STAGE: March 14, 2018
JOURNAL
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[in Japanese]
Article type: Article
1986 Volume 60 Issue 10 Pages
510-511
Published: October 25, 1986
Released on J-STAGE: March 14, 2018
JOURNAL
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[in Japanese]
Article type: Article
1986 Volume 60 Issue 10 Pages
511-512
Published: October 25, 1986
Released on J-STAGE: March 14, 2018
JOURNAL
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[in Japanese]
Article type: Article
1986 Volume 60 Issue 10 Pages
512-515
Published: October 25, 1986
Released on J-STAGE: March 14, 2018
JOURNAL
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