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Volume 98 (2024)
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- Issue 3 Pages 91-
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Volume 98, Issue 3
Displaying 1-23 of 23 articles from this issue
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Eikan Mishima2024 Volume 98 Issue 3 Pages 91-96
Published: March 25, 2024
Released on J-STAGE: March 31, 2025
JOURNAL OPEN ACCESSVitamin K was discovered as an essential factor in blood coagulation in 1929. Subsequent research has reported the intricate metabolic pathway of the vitamin K cycle and has also revealed its diverse physiological roles beyond coagulation. In addition, warfarin, a vitamin K antagonist, has widely used as an anticoagulant drug worldwide. Our recent study has unveiled an additional physiological function of vitamin K, i.e., its role in inhibiting ferroptosis, a form of regulated cell death, through our study on cell death. Furthermore, in our study on the role of vitamin K in inhibiting ferroptosis, ferroptosis suppressor protein-1 (FSP1) has been identified to be warfarin-resistant vitamin K reductase, although the molecular identity of warfarin-resistant vitamin K reductase has not been clarified for over five decades despite its acknowledged existence. This finding has led to elucidation for the molecular mechanism underlying the antidotal effect of vitamin K against warfarin poisoning.View full abstractDownload PDF (975K) -
Akimori Wada, Ichiro Matsuda, Tomohiro Koyama, Hinata Satou, Toshio Ok ...2024 Volume 98 Issue 3 Pages 97-107
Published: March 25, 2024
Released on J-STAGE: March 31, 2025
JOURNAL OPEN ACCESSVarious ethyl dihydroretionates were prepared by the conjugate reduction of β-ionylidenacetaldehydes and C-18 ketones using ethyldimethylsilyl hydride and subsequent Emmons-Horner reaction with C5- or C2-phosphonate. These esters were hydrolyzed to afford the corresponding dihydroretinoic acids and their biological activities were evaluated. Among the synthesized analogs, 8Z-7,10-dihydroretinoic acid showed higher transcriptional activities for the retinoid X receptor responsive element gene and for the RXRα-GAL4 expression gene than 9Z-retinoic acid (a natural ligand).View full abstractDownload PDF (1138K) -
Misora Ao, Masaaki Awane, Yoshito Asao, Sadahiko Kita, Takashi Miyawak ...2024 Volume 98 Issue 3 Pages 108-111
Published: March 25, 2024
Released on J-STAGE: March 31, 2025
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Hiromitsu Ohmori, Akihiko Kato, Yuka Shirai, Reiji Fukano, Akiko Nagae ...2024 Volume 98 Issue 3 Pages 112-115
Published: March 25, 2024
Released on J-STAGE: March 31, 2025
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Kiyoshi Tanaka, Misora Ao, Akiko Kuwabara2024 Volume 98 Issue 3 Pages 116-120
Published: March 25, 2024
Released on J-STAGE: March 31, 2025
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Mai Kubota, Tomoya Kitakaze, Naoki Harada, Ryoichi Yamaji2024 Volume 98 Issue 3 Pages 121-124
Published: March 25, 2024
Released on J-STAGE: March 31, 2025
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[in Japanese]2024 Volume 98 Issue 3 Pages 125-126
Published: 2024
Released on J-STAGE: March 31, 2025
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[in Japanese]2024 Volume 98 Issue 3 Pages 126
Published: 2024
Released on J-STAGE: March 31, 2025
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]2024 Volume 98 Issue 3 Pages 126-127
Published: 2024
Released on J-STAGE: March 31, 2025
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[in Japanese]2024 Volume 98 Issue 3 Pages 127-128
Published: 2024
Released on J-STAGE: March 31, 2025
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...2024 Volume 98 Issue 3 Pages 128-129
Published: 2024
Released on J-STAGE: March 31, 2025
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[in Japanese], [in Japanese], [in Japanese]2024 Volume 98 Issue 3 Pages 129
Published: 2024
Released on J-STAGE: March 31, 2025
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[in Japanese]2024 Volume 98 Issue 3 Pages 129-130
Published: 2024
Released on J-STAGE: March 31, 2025
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[in Japanese]2024 Volume 98 Issue 3 Pages 130-131
Published: 2024
Released on J-STAGE: March 31, 2025
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[in Japanese]2024 Volume 98 Issue 3 Pages 131
Published: 2024
Released on J-STAGE: March 31, 2025
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[in Japanese]2024 Volume 98 Issue 3 Pages 131-132
Published: 2024
Released on J-STAGE: March 31, 2025
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[in Japanese]2024 Volume 98 Issue 3 Pages 132-133
Published: 2024
Released on J-STAGE: March 31, 2025
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[in Japanese]2024 Volume 98 Issue 3 Pages 133-134
Published: 2024
Released on J-STAGE: March 31, 2025
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...2024 Volume 98 Issue 3 Pages 135
Published: 2024
Released on J-STAGE: March 31, 2025
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[in Japanese]2024 Volume 98 Issue 3 Pages 136
Published: 2024
Released on J-STAGE: March 31, 2025
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]2024 Volume 98 Issue 3 Pages 137
Published: 2024
Released on J-STAGE: March 31, 2025
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]2024 Volume 98 Issue 3 Pages 137-138
Published: 2024
Released on J-STAGE: March 31, 2025
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]2024 Volume 98 Issue 3 Pages 138-139
Published: 2024
Released on J-STAGE: March 31, 2025
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