アレルギー
Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
10 巻, 6 号
選択された号の論文の6件中1~6を表示しています
  • 原稿種別: 目次
    1961 年 10 巻 6 号 p. 1-4
    発行日: 1961/06/30
    公開日: 2016/10/20
    ジャーナル フリー
  • 大島 良雄, 宮本 昭正, 荒木 英斉, 牧野 荘平, 可部 順三郎, 大塚 正巳, 広瀬 俊一, 横張 竜一, 石崎 達
    原稿種別: 本文
    1961 年 10 巻 6 号 p. 341-353
    発行日: 1961/06/30
    公開日: 2016/10/20
    ジャーナル フリー
  • 荒木 英斉
    原稿種別: 本文
    1961 年 10 巻 6 号 p. 354-370,381
    発行日: 1961/06/30
    公開日: 2016/10/20
    ジャーナル フリー
    Incidence of sensitization with several air-borne pollens was studied in the Japanese mainly by direct intradermal test, and in some cases Prausnitz-Kustner test, eye test, and provocation by pollen inhalation were studied also. Individuals tested were 265 patients with bronchial asthma, 70 patients with nasal allergy and 602 control persons. Pollens used were short ragweed (Ambrosia artemisiifolia var. elatior), Japanese red pine(Pinus densiflora), Japanese black pine (Pinus Thumbergi), Japanese cedar (Cryptomeria japonica), and Japanese hop (Humulus japonicus). For the comparative study, house dust was also used. In direct skin testing, 0.05 ml of allergen extracts of 1:1000 dilution was injected intracutaneously. In asthmatic patients, each of the distribution curves of diameters of erythema and wheal caused by the intradermal injection with house dust extract showed two peaks with a minimum between them, and the minimum point situated at 15〜20 mm in erythema and 9 mm in wheal. Similar figures were obtained in normal control persons. With short ragweed pollen, it was the same. The first peak, which was estimated to correspond to unspecific reactions, was lower than that of normal control persons, while the second peak which was considered to correspond to specific reactions was higher in asthmatic patients. Only few normal persons and fairly numerous asthmatic patients showed the erythema reactions above 41 mm in diameter. The correlation between erythema and wheal was high (r=0.80 in house dust. r=0.78 in ragweed pollen). From these results. the author proposed the following criteria of intradermal skin test with inhalant allergens; negative (-): erythema less than 10 mm in diameter doubtful (±): erythema 11-20 mm slightly positive (+): erythema 21-40 mm, wheal less than 9 mm moderately positive (〓): erythema 21-40 mm, wheal 10-14 mm strongly positive (〓): erythema above 41 mm, or wheal above 15 mm, or with marked pseudopods After these standards, positive skin reactions to short ragweed pollen were observed in 36% of asthmatic patients, 32% of patients with nasal allergy including bacterial allergy, 52% of patients with nasal allergy except bacterial allergy, and 19% of normal control persons, whereas positive skin reactions to house dust in these four groups were 69%, 51%, 65%, and 23% respectively. But positive skin reactions to Japanese red pine and Japanese cedar pollens were observed far less frequently than that to ragweed pollen, and only very few cases reacted to Japanese black pine and Japanese hop pollens. PK-test was successful in 7 of 11 cases who showed positive intradermal reaction to short ragweed pollen, and in 2 of 3 cases who showed positive intradermal reaction to Japanese red pine pollen. Eye test was carried out with the extracts of pollens, and provocative test by inhalation was done with pollen itself. Both of these test showed positive reactions in rather few cases. Cross reaction between house dust and short ragweed pollen were proved by PK-reaction. House dust might have more allergenic components than short ragweed pollen as judged by skin test. A Japanese patient, who never been abroad but suffering from allergic rhinitis and laryngitis evidently caused by short ragweed pollen, was described in details. Some possible explanations concerning the discrepancy between the results of skin test and the incidence of pollinosis were discussed.
  • 木村 義民, 鈴木 広造, 高橋 昌巳
    原稿種別: 本文
    1961 年 10 巻 6 号 p. 371-376,382
    発行日: 1961/06/30
    公開日: 2016/10/20
    ジャーナル フリー
    The relationship between the intensity of Arthus phenomenon and the antibody titer in the actively sensitized rabbit with purified egg-albumin was investigated. Antibody titer were determined by precipitation reaction, Boyden's hemagglutination reaction and Commb's test. In summary, in the most of the cases the Arthus reaction seems to parralel to the titer of precipitin and haemoagglutination reaction (complete antibody), but in some cases it is rather crossly related to incomplete antibody titer. For the purpose of separating the complete and incomplete antibody in anti-eggalbumin rabbit sera, ultracentrifugation technique (modified Campbell's technique) and the freezing-thawing procedure (by Matsuhashi or Yoshitake's method) were carried out. The distribution of the complete and incomplete antibody in the upper, middle and lower parts of the fractions by the above two methods were so similar; most of the complete antibody was found in the precipitate, though including incomplete antibody, howerver, in the upper part complete antibody hardly could by found, but incomplete antibody was still remained. By studying the influence of heating upon the antibody titer, the complete antibody was found to be completely inactivated at 73C for 30 minutes, but no effect upon the activity of the incomplete antibody was observed. The passive sensitizing activity in producing anaphylaxis in the guinea pig was demonstrated with anti-eggalbumin rabbit sera removed of complete antibody by ultracentrifugation or inactivated complete antibody by heating(73C for 30 min). These facts suggest that incomplete antibody have some significant role in the passive sensitization of producing anaphylaxis.
  • 八田 亨二
    原稿種別: 本文
    1961 年 10 巻 6 号 p. 377-380,382
    発行日: 1961/06/30
    公開日: 2016/10/20
    ジャーナル フリー
    Following the Yamamura's method, adult rabbits were sensitized with subcutaneous injections of tuberculous bacilli (Miwa strain) killed by boiling in water and suspended in Freund's adjuvant. Affer the sensitization, the rabbits received the secondary injection of the antigen, i.e., killed bacilli of the same strain, into their lungs. At various weeks after the injection, tissues of tuberculous lesions were homogenized and centrifuged, and the amount of adsorbed complement in the supernatant was determined. Adsorption of complement began to increase soon after the injection of the secondary antigen, the peak being reached at the end of the second weed. On the 4th week, a sudden decrease took place. If diluted solution of tuberculin was added to the supernatant in vitro, the amount of adsorbed complement was approximately two times larger than that in experiment without tuberculin, a marked increase occurring two weeks after the injetion. The antibody in the lesions seems to resemble in nature the incomplete antibody reported by Sindo et al. in the case of tuberculosis. Relationship between the antibody in tuberculous lesions and pathological changes in the lesions has been discussed.
  • 原稿種別: 文献目録等
    1961 年 10 巻 6 号 p. 381-382
    発行日: 1961/06/30
    公開日: 2016/10/20
    ジャーナル フリー
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