アレルギー
Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
9 巻, 9 号
選択された号の論文の12件中1~12を表示しています
  • 原稿種別: 表紙
    1960 年 9 巻 9 号 p. Cover13-
    発行日: 1960/09/01
    公開日: 2016/10/20
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  • 原稿種別: 表紙
    1960 年 9 巻 9 号 p. Cover14-
    発行日: 1960/09/01
    公開日: 2016/10/20
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  • 亀山 昭一
    原稿種別: 本文
    1960 年 9 巻 9 号 p. 709-715
    発行日: 1960/09/01
    公開日: 2016/10/20
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    A number of guinea pigs previously immunized with diphtheria toxoid received each a second dose of the toxoid subcutaneously, and changes in the circulating antitoxin and the neutralization power of the skin were followed. The latter was determined by the quantitative Schick test (QST). The circulating antitoxin decreased soon after the second injection and reached the minimum value after 24 hours. The neutralizing power of the skin also decreased as the circulating antitoxin fell. However, the linear relationships were always recognized between the neutralizing power of the skin and the amount of circulating antitoxin observed just before the QST. Statistical analysis suggested that the relative value of the neutralization power of the skin to the circulating antitoxin ("neutralization index") seemed to be similar during 48 hours after the second dose of toxoid, while the significant decrease of"neutralization index"was observed after 72 hours. Another groups of similarly immunized guinea pigs received the QST at first and then they were injected with the second dose of toxoid at various time interval, and the effect of the latter on the results of QST was followed. The second dose given simultaneously or shortly after the QST (-e.g. 2 hours) seemed to lower the neutralization power of the skin significantly, but no effect was observed when it was given 16 hours after the QST.
  • 亀山 昭一
    原稿種別: 本文
    1960 年 9 巻 9 号 p. 716-721
    発行日: 1960/09/01
    公開日: 2016/10/20
    ジャーナル フリー
    Experiment was planned to see whether or not the diphtheric infection develops during the course of"negative Phase"caused by the toxoid injection to the actively immunized guinea pigs. The antitoxin level necessary to prevent the conjunctival infection was about 0.003 unit per ml in the actively immunized guinea pigs, while animals having the antitoxin more than 0.1-0.3 unit proved to be susceptible to infection by virulent diphtheria bacilli for a while after they had received a large amount of toxoid (250 Lf per animal). However, the results do not necessarily lead to the critical opinion against the present tendency to immunized population during epidemics, since the amount usually used in the prophylaxis is very small when compared with that necessary to lower the resistance of the animals significantly. Moreover, the beneficial effect of the toxoid injection during epidemics might be supported by the fact that the rapid reproduction of the antitoxin after the negative phase may serve to prevent the clinical manifestations of the diphtheria infection in human beings.
  • 山口 正民, 小川 弥栄, 遠藤 一男, 中井 睦雄
    原稿種別: 本文
    1960 年 9 巻 9 号 p. 722-729
    発行日: 1960/09/01
    公開日: 2016/10/20
    ジャーナル フリー
    Yamamura et al. have previously reported that an antigen-antibody reaction in tuberculosis plays an important role in cavitation of lungs. According to these findings, it was attempted to prevent the experimental formation of tuberculous cavities in rabbit lungs by the daily injections of anti-allergic drugs. Various doses of cortisone acetate, "Strong Neo-Minophagen C"and"Glycyron"were injected to the experimental animals subcutaneously, which received the treatment to produce tuberculous cavities by Yamamura's method. The animals were sacrificed for pathological examinations 50 and 80 days after pulmonary injections. Productive changes were significantly pronounced in the lungs of the animals injected"Glycyron"1 mg/kg and cortisone 2 mg/kg, while exudative as well as caseous changes were remarkably found in the other animals.
  • 直木 由太郎
    原稿種別: 本文
    1960 年 9 巻 9 号 p. 730-746
    発行日: 1960/09/01
    公開日: 2016/10/20
    ジャーナル フリー
    Shock of the brain was induced by injecting the anti-rabbit red cell dog serum into the carotid artery, other arteries and veins of rabbits, and histological changes in the brain caused by this reversed anaphylaxis process were investigated. The severest histological changes were observed in the rabbits injected provocatively into the carotid artery, and the findings observed in the rabbits injected provocatively into other arteries and veins were rather milder. In the control group, in which the normal dog serum was injected into the carotid artery of rabbits, no significant changes were detected. The histological findings of the central nervous system of rabbits injected provocatively were the focal and diffuse glial proliferation, the degeneration of ganglion cells, congestion, hemorrhage and several degrees of edema. Besides thess changes, the lucid plaque which is the synonym of the patch of necrosis, are found in the brain tissue of the rabbits injected provocatively into the carotid artery. Demyelinization was observed on the site of the lucid plaques. These studies suggest that breakdown of the blood brain barrier can be effected by the intravascular antigen-antibody reaction.
  • 成宮 道太郎
    原稿種別: 本文
    1960 年 9 巻 9 号 p. 747-765
    発行日: 1960/09/01
    公開日: 2016/10/20
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    Experimental allergies are produced in rabbits by the injection of the mixture of the liver phosphatide and ox serum as the antigen. After its reinjection no remarkable changes are seen histologically in the liver, but severe anemia are occurred transiently after the reinjection. Since Eppinger reported the experimental results on serous inflamation and liver cirrhosis caused by allylformiat, it has been found that allylformiat has the affinity to the liver. When the experimental allergies are produced by the injection of the mixture of allylformiat and ox serum as the antigen, no histological changes are seen in the liver after the reinjection, but changes of serum cobaltreaction and Takata's reaction and appearance of urobilinogen in urin are observed after the reinjection. These data may caused by the allergic damage of the liver after the reinjection. It seems, therefore, that the transient allergic anemia due to the reinjection may cause the allergic functional damage of liver, especially disturbance of metabolism of phosphatide and protein.
  • 小田原 健
    原稿種別: 本文
    1960 年 9 巻 9 号 p. 766-779
    発行日: 1960/09/01
    公開日: 2016/10/20
    ジャーナル フリー
    Since Eppinger's experiments it has been ascertained that Allylformiat damages the liver cells. When the experimental allergies are produced in rabbits by the injection of the mixture on allylformiat and ox serum as the antigen, the allergic anemia could be seen transiently after the reinjection. This anemia is studied analytically, and it is ascertained that the anemia is a hypoplastic anemia, such as the"Erythron-Allergy"caused by the red cell pposphatide. In the myelogram obtained after the reinjection, megaloblasts are not found. Therefore, this anemia is not of pernicious in nature.
  • 原稿種別: 文献目録等
    1960 年 9 巻 9 号 p. 780-782
    発行日: 1960/09/01
    公開日: 2016/10/20
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  • 原稿種別: 付録等
    1960 年 9 巻 9 号 p. App6-
    発行日: 1960/09/01
    公開日: 2016/10/20
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  • 原稿種別: 表紙
    1960 年 9 巻 9 号 p. Cover15-
    発行日: 1960/09/01
    公開日: 2016/10/20
    ジャーナル フリー
  • 原稿種別: 表紙
    1960 年 9 巻 9 号 p. Cover16-
    発行日: 1960/09/01
    公開日: 2016/10/20
    ジャーナル フリー
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