Shock of the brain was induced by injecting the anti-rabbit red cell dog serum into the carotid artery, other arteries and veins of rabbits, and histological changes in the brain caused by this reversed anaphylaxis process were investigated. The severest histological changes were observed in the rabbits injected provocatively into the carotid artery, and the findings observed in the rabbits injected provocatively into other arteries and veins were rather milder. In the control group, in which the normal dog serum was injected into the carotid artery of rabbits, no significant changes were detected. The histological findings of the central nervous system of rabbits injected provocatively were the focal and diffuse glial proliferation, the degeneration of ganglion cells, congestion, hemorrhage and several degrees of edema. Besides thess changes, the lucid plaque which is the synonym of the patch of necrosis, are found in the brain tissue of the rabbits injected provocatively into the carotid artery. Demyelinization was observed on the site of the lucid plaques. These studies suggest that breakdown of the blood brain barrier can be effected by the intravascular antigen-antibody reaction.
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